Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.3 (dihydrofolate reductase)
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Human Gene/Protein
DHFR 12.4
TAFII-105 12.4
dihydrofolate reductase-like 1 12.4
RING3-like protein 12.4
dihydrofolate reductase 12.4
dihydrofolate reductase-like protein 1 12.1
HLA-SB beta 11.4
Cholesterol 27-hydroxylase 11.4
SS18L2 11.4
DHFRP2 11.4
Endothelial nitric oxidase synthase 11.4
HCG1 11.4
glycinamide ribonucleotide formyltransferase 11.3
Dihydrofolate reductase 11.3
DHPS 10.9
TRAF interacting protein 10.8
MRP-L20 10.8
beta adaptin 10.8
mutS homolog 3 10.8
folylpolyglutamate synthetase 10.5
TGF-beta activated kinase 10.4
MnSOD precursor 10.4
SSXT 10.4
COPG1 10.4
folylpoly-gamma-glutamate synthetase 10.1
thymidylate synthase 10.1
TAFII105 10.1
ACTR1A 10.1
C12orf35 10.1
OVCA2 10.1
RING3 protein 10.1
HIP1 protein 10.1
RPF2 9.8
serine hydroxymethyltransferase 1 9.7
cytoplasmic serine hydroxymethyltransferase 9.6
RAPGEF6 9.6
Cytochrome c oxidase subunit II 9.4
PDXDC1 9.4
TBP associated factor 9.4
PHS2 9.4
SQM1 9.4
DYR 9.4
MTHFD1 9.4
solute carrier family 19 member 1 9.4
SRRF 9.4
thymidylate synthetase 9.4
reduced folate carrier 9.4
SHMT1 9.3
PSMD13 9.2
NADPH oxidase organizer 1 9.2
NFRKB 9.2
L-alanine:glyoxylate aminotransferase 9.2
I-TRAF 9.2
GADD45 gamma 9.2
sepiapterin reductase 9.2
MTHFD2 9.1
Formiminotransferase-cyclodeaminase 9.1
dipeptidyl peptidase 9 9.1
TFDP1 9.1
MAST4 9.1
C1-tetrahydrofolate synthase 9.1
FTCD 9.1
serine hydroxymethyltransferase 2 9.0
Sepiapterin reductase 9.0
FOXJ3 9.0
IFN-alpha 5 9.0
TSase 9.0
SS18L1 9.0
SLC19A1 8.9
RAB1 8.9
60kD 8.8
FKBP-25 8.8
SRPR 8.8
UFD2 8.8
purH 8.8
MTHFS 8.8
delta globin 8.8
SEC13 8.7
ALDH1L2 8.7
ribosomal protein L36 8.7
more...
Disease
Dihydrofolate reductase deficiency 11.4
R-binder deficiency 10.8
glutamate formiminotransferase deficiency 10.1
methionine synthase deficiency 9.4
Squamous Cell Cancer 8.8
ASSA 8.7
transcobalamin II deficiency 8.7
DA5 8.6
Stenotrophomonas maltophilia infection 8.3
AKE 8.2
DHPR deficiency 7.9
cblF 7.6
Downbeat nystagmus 7.4
Diabetic gastroparesis 7.0
CEM 6.8
bacterial dysentery 6.7
Plasmodium falciparum malaria 6.5
XPE 6.5
Enzyme inhibition 6.4
folate deficiency 6.4
stage III colorectal cancer 6.3
mouse leukemia L1210 6.2
Ovary 6.1
isosporiasis 6.0
VRSA 5.9
DSH 5.7
pediatric solid tumor 5.5
orotic aciduria 5.5
hyperphenylalaninemia 5.5
Ovary 5.4
Choriocarcinoma 5.3
malaria 5.3
Shigella sonnei 5.3
Cockayne syndrome 5.2
cryptosporidiosis 5.2
MPS IIIA 5.2
Shaver 5.1
myelosuppression 5.0
lymphoblastic leukemia 5.0
Condensation 4.9
coprophagy 4.8
AT3 4.8
AT3 4.8
AT3 4.8
AT3 4.8
AT3 4.8
AT3 4.8
AT3 4.8
AT3 4.8
ARH 4.8
AT3 4.8
LIS1 4.8
Plasmodium vivax infection 4.8
nagana 4.8
sarcoma 180 4.8
pharyngotonsillitis 4.7
childhood ALL 4.7
xeroderma pigmentosum 4.7
acute monocytic leukemia 4.6
TNS 4.6
Parvovirus B19 infection 4.6
Shigella boydii 4.5
mesothelioma 4.5
familial Alzheimer disease 4.5
megaloblastic anemia 4.4
refractory cancer 4.3
choriocarcinoma 4.3
Tropical Diseases 4.3
Sanfilippo 4.3
PCP 4.3
toxoplasmosis 4.3
HMS 4.3
CMD 4.2
CMD 4.2
riboflavin deficiency 4.2
TTP 4.2
retinoblastoma 4.1
FIM 4.1
African trypanosomiasis 4.1
AIDS-related Kaposi's sarcoma 4.1
more...
Symptom
inanition 4.6
general problem 2.7
DNA marker 2.6
muscle rigidity 2.3
nausea and vomiting 2.2
starvation 1.7
diarrhea 0.9
HSA 0.9
collapse 0.6
dystonia 0.4
nausea 0.2
vomiting -0.2
spasticity -0.2
erythema -0.3
ataxia -0.5
splenomegaly -0.9
agitation -1.1
exhaustion -1.3
anorexia -1.3
acidity -1.5
tremor -1.8
weakness -1.8
fatigue -2.2
overweight -2.3
dyspnea -2.4
abdominal pain -2.5
seizures -2.9
headache -3.4
pain -3.6
anesthesia -4.3
Drug
Met-Tyr-Gly 12.4
Alimta 10.3
Tmr 10.1
Pemetrexed disodium 9.6
Trimetrexate glucuronate 9.4
Pemetrexed 9.2
Pralatrexate 9.0
7-Methylguanosine 8.8
Methotrexat 8.4
1,2,4-Triazole 8.2
Fansidar 8.1
Fansidar 8.0
Forodesine 7.9
Paraplatin 7.9
THF 7.4
Thyrogen 7.4
Compound 18 7.2
TMX 7.1
Toltrazuril 7.1
BH4 7.1
Leucovorin 7.0
Atovaquone 7.0
Atovaquone 6.9
Gemzar 6.9
Orthoclone OKT3 6.8
Allegra 6.7
Allegra 6.7
Amprolium 6.7
Folic Acid 6.4
Bactrim 6.4
Malarone 6.4
Trimethoprim-sulfamethoxazole 6.2
Glide 6.1
G418 5.9
Navelbine 5.9
Compound 16 5.7
Isoprinosine 5.6
Compound 15 5.5
Trypanothione 5.5
Doripenem 5.4
Pertuzumab 5.4
FSH-beta 5.2
Dithranol 5.1
Asn 5.1
Artesunate 5.0
Dihydro 5.0
Vinorelbine 4.7
Trib 4.6
ARA-C 4.6
Miltefosine 4.5
Primaquine 4.5
Compound 9 4.4
Propidium 4.4
AGG 4.4
Ketotifen 4.2
Ergosterol 4.1
Mycophenolic acid 4.0
TRM 3.9
Kenyan 3.8
GEO 3.8
CTT 3.7
Arsenic trioxide 3.7
MEA 3.6
Epigallocatechin 3.6
Meth 3.6
Oxaliplatin 3.6
OMP 3.5
Isoniazid 3.5
ampicillin 3.5
DNase I 3.3
Clofibrate 3.3
Fragment 3.2
Urokinase 3.1
Lovastatin 3.0
OTC 2.9
PMEA 2.9
Erlotinib 2.9
IFN-beta 2.9
Campath 2.9
Campath 2.9
more...
Enzyme
dihydrofolate reductase 12.4
formyltransferase, dihydrofolate 12.4
dihydropteroate synthase 11.2
blasticidin-S deaminase 10.8
PTR1 10.7
folylpolyglutamate synthetase 10.5
EC 2.7.4.4 10.4
Cpro-2 10.4
3-N-aminoglycoside acetyltransferase 10.1
deoxynucleoside monophosphate kinase 10.1
thymidylate synthase 10.1
glutamate formiminotransferase 10.0
dihydrofolate synthetase 9.8
glycinamide ribonucleotide transformylase 9.5
dCMP hydroxymethylase 9.5
sepiapterin reductase 9.2
AICAR transformylase 9.2
dCTPase 9.0
HPPK 9.0
5,10-methenyltetrahydrofolate synthetase 8.9
methylenetetrahydrofolate dehydrogenase 8.9
aromatic amine dehydrogenase 8.5
methylenetetrahydrofolate dehydrogenase 8.5
formyltetrahydrofolate synthetase 8.4
dCMP deaminase 8.4
D-aminopeptidase 8.3
aminoglycoside adenylyltransferase 8.2
serine hydroxymethyltransferase 8.2
streptomycin adenylyltransferase 8.1
malyl-CoA lyase 8.1
dihydropteridine reductase 7.9
carboxypeptidase G2 7.9
uridine hydrolase 7.9
6-pyruvoyltetrahydropterin synthase 7.9
alpha-1,4-glucan lyase 7.7
L-asparagine synthetase 7.6
adenosine nucleosidase 7.6
IMP dehydrogenase 7.5
GTP cyclohydrolase I 7.5
aminoglycoside 6'-N-acetyltransferase 7.5
conjugase 7.4
dihydroorotase 7.4
cyclohydrolase 7.4
enoyl-ACP reductase 7.3
enoyl-ACP reductase 7.3
phenylalanyl-tRNA synthetase 7.3
Streptomyces griseus protease B 7.2
dCTP deaminase 7.1
amidophosphoribosyltransferase 7.1
thymidylate kinase 7.1
kynurenine formamidase 7.0
D-amino acid aminotransferase 7.0
endothiapepsin 6.9
dUTPase 6.9
methionine synthase 6.8
dihydroneopterin aldolase 6.8
methionine synthase reductase 6.8
GMP synthase 6.6
alpha-lytic protease 6.6
GMP reductase 6.6
methionine synthase 6.6
orotidine-5'-phosphate decarboxylase 6.6
p-hydroxybenzoate hydroxylase 6.6
CTP synthase 6.5
MetE 6.5
aspartate transcarbamylase 6.5
GAR 6.5
carboxypeptidase D 6.5
adenine phosphoribosyltransferase 6.4
pantothenate synthetase 6.4
Tpt1 6.4
10-formyltetrahydrofolate dehydrogenase 6.3
Dm-dNK 6.2
xanthine phosphoribosyltransferase 6.2
nicotinic acid phosphoribosyltransferase 6.2
hygromycin B phosphotransferase 6.2
p-hydroxybenzoate hydroxylase 6.1
methylenetetrahydrofolate reductase 6.1
glycine N-methyltransferase 6.1
benzoylformate decarboxylase 6.1
more...
Compound
2,4-diaminopyrido[2,3-d]pyrimidine-6-carbonitrile 12.4
Etoprine 12.4
Bisbrusatolyl malonate 12.4
6-(bromomethyl)-2,4-pteridinediamine 12.0
BW 301U 11.5
C8H7N7 11.4
Tetrahydroneopterin 11.4
4-phenyl-1,2,4-triazolidine-3,5-dione 11.4
C9H10Cl2O2 11.4
dihydrofolate 11.4
Trimetrexate 11.2
TMQ 11.2
C8H7N7 10.8
Microlenin 10.8
Homofolate 10.8
1843U89 10.8
Diaveridine 10.6
tert-butyl cyanoacetate 10.4
C4H4N2O2 10.4
5-bromotryptophan 10.4
Chloroquinoxaline sulfonamide 10.1
Cirsilineol 10.1
2-(tert-butylamino)ethanol 10.1
ethyl isocyanatoacetate 10.1
C20H24O6 10.1
N-methylbenzenesulfonamide 10.1
2-Aminopyrimidine 10.1
Aminopterin 10.0
Sulfadoxine 10.0
Conformer B 9.8
10-formyldihydrofolate 9.8
Baker's Antifol 9.8
Dihydropteroate 9.7
Pyrimethamine 9.7
PRPP 9.7
Proguanil 9.7
pteridine 9.6
2-cyanoacetohydrazide 9.6
DDMP 9.6
7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 9.4
4-pyrimidinol 9.4
cTMP 9.4
6-Methyluracil 9.2
ZD1694 9.1
Trimethoprim 9.1
7,8-Dihydrobiopterin 9.0
methyl 4-formylbenzoate 9.0
Sepiapterin 9.0
2-butanone oxime 8.8
7-Methylguanosine 8.8
2-methylquinoxaline 8.8
NAAAF 8.8
5,10-methylene-THF 8.7
2,4-pyrimidinediamine 8.7
2,4-Diamino-6-hydroxypyrimidine 8.7
5-formyltetrahydrofolate 8.6
10-formyltetrahydrofolate 8.5
Methotrexate 8.5
1,2,3-trimethoxybenzene 8.4
ethyl trifluoroacetate 8.4
ethyl trifluoroacetate 8.4
6-pyruvoyltetrahydropterin 8.4
MTX 8.3
6-Azauridine 8.2
Diaminopyridine 8.2
2-Acetylpyridine 8.2
6-fluorotryptophan 8.2
4-methyleneglutamic acid 8.2
CH3-THF 8.0
1-naphthalenesulfonic acid 8.0
1-naphthalenesulfonic acid 8.0
dUMP 8.0
1-benzothiophene 8.0
(aminooxy)acetic acid 8.0
6R-BH4 8.0
5,10-methenyltetrahydrofolate 7.9
7H-pyrrolo[2,3-d]pyrimidine 7.9
Biopterin 7.9
1,3-dichloroacetone 7.7
folinic acid 7.7
more...