Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.5.1.3 (dihydrofolate reductase)
5,819 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein dihydrofolate reductase 5221 DHFR 959 Mol 638 thymidylate synthase 598 Sep 445 NADPH 388 fused 174 NMR 168 reductase 161 Dihydrofolate reductase 153 MTX 125 thymidylate synthetase 125 polypeptide 124 ATP 98 NADP+ 89 folylpolyglutamate synthetase 87 hormone receptor 73 thymidine kinase 73 NADP 70 p53 67 glycinamide ribonucleotide formyltransferase 56 MIC 54 reduced folate carrier 51 c-myc 48 oxidoreductase 47 SDS 44 tRNA 42 TMP 41 ACS 40 Sp1 36 DNA polymerase 35 MTHFR 34 E2F1 33 glycoprotein 33 osteosarcoma 33 RNA polymerase II 32 dimeric 31 endonuclease 31 RFC) 31 ribonucleotide reductase 31 GTP 30 DNA polymerase alpha 29 ubiquitin 28 ras 28 housekeeping 27 Gen 27 endoplasmic reticulum 26 cytochrome 26 interferon 25 precursor protein 25 P-glycoprotein 25 methylenetetrahydrofolate reductase 24 proteasome 24 DHPS 24 Pseudomonas 23 NAD 22 NADH 22 cyclin A 21 Met 21 serine hydroxymethyltransferase 21 sepiapterin reductase 20 B12 20 membrane protein 20 chaperonin 20 nitric oxide synthase 20 E2F-1 20 insulin 19 cyclin 19 metallothionein 19 c-fos 19 histone 19 AMP 19 MTR 18 MOLT 18 dihydropteridine reductase 18 lactate dehydrogenase 18 cytochrome b 18 cytokine 18 hGH 18 MTRR 17 more...

Disease cancer 588 tumor 382 malaria 315 leukemia 230 CEM 88 breast cancer 82 carcinoma 76 Mycobacterium 71 AIDS 55 tuberculosis 54 pneumonia 49 HIV 47 MCF 47 SDS 44 hepatocellular carcinoma 44 acute lymphoblastic leukemia 39 carcinogenesis 38 osteosarcoma 36 retinoblastoma 36 myelosuppression 35 Plasmodium falciparum malaria 34 infectious diseases 34 adenocarcinoma 31 rheumatoid arthritis 30 lymphoma 30 melanoma 30 mesothelioma 29 lung cancer 29 colorectal cancer 27 cytomegalovirus 27 squamous cell carcinoma 26 non-small cell lung cancer 26 folate deficiency 26 Leukemia 25 herpes simplex 25 PCP 25 toxoplasmosis 25 colon cancer 24 Infection 22 immunodeficiency 22 lymphoblastic leukemia 22 lung carcinoma 21 leishmaniasis 20 metastases 19 fits 19 glioma 17 neutropenia 17 sarcoma 16 psoriasis 16 cryptosporidiosis 16 cold 16 thrombocytopenia 16 tumor growth 15 choriocarcinoma 15 acute myeloid leukemia 15 Epstein 14 Klebsiella 14 hepatitis B 14 anemia 14 xeroderma pigmentosum 14 Ovary 14 multiple myeloma 14 Ovary 14 solid tumor 13 mole 13 arthritis 13 mole 13 Chagas 13 diabetes 13 epithelial ovarian cancer 13 hypertension 13 Kaposi's sarcoma 12 SAR 12 rash 12 childhood ALL 12 fibrosarcoma 12 ovarian cancer 11 leukopenia 11 tumor progression 11 TEM 11 more...

Symptom diarrhea 20 starvation 15 nausea and vomiting 8 collapse 8 vomiting 5 nausea 5 pain 4 seizures 2 ataxia 2 dystonia 2 erythema 2 weakness 2 fatigue 2 inanition 1 headache 1 splenomegaly 1 spasticity 1 DNA marker 1 exhaustion 1 agitation 1 dyspnea 1 abdominal pain 1 general problem 1 anesthesia 1 overweight 1 tremor 1 acidity 1 muscle rigidity 1 anorexia 1 HSA 1

Drug THF 260 Asn 72 lysine 51 Pemetrexed 45 BH4 37 ampicillin 34 G418 25 NADH 24 Alimta 18 DNase I 15 Gel 13 Leucovorin 12 Fansidar 12 Fansidar 12 IFN-gamma 11 CSF 10 Kenyan 9 ABC 8 Glide 8 IL-2 8 caffeine 7 Dermatol 7 Mutagen 7 CTX 6 Atovaquone 5 ICI 5 Pemetrexed disodium 5 Trimethoprim-sulfamethoxazole 5 lactose 5 GEO 4 ROS 4 IFN-beta 4 Fragment 4 Angiotensin II 4 CTX 4 Atovaquone 4 CTX 4 Gemzar 4 Fluorescein 4 FAD 3 Pralatrexate 3 Fluorescein 3 Dihydro 3 Meth 3 TAT 3 NH3 3 AGG 3 Alanine 3 Leaf 3 MAP 3 Trib 3 Compound 18 3 ETS 3 Bactrim 3 Arsenic trioxide 3 G-CSF 3 Paraplatin 2 TTC 2 Artesunate 2 Methotrexat 2 ascorbate 2 Isoniazid 2 Oxaliplatin 2 Adriamycin 2 ACT 2 Lovastatin 2 Navelbine 2 Vinorelbine 2 Biopolymers 2 Nitric Oxide 2 TMX 2 Dakar 2 Taxol 2 Tmr 1 Rosiglitazone 1 EE2 1 ADR 1 CTT 1 ROC 1 Riboflavin 1 more...

Enzyme dihydrofolate reductase 5819 thymidylate synthase 702 dihydropteroate synthase 230 folylpolyglutamate synthetase 90 thymidine kinase 73 DNA polymerase 71 RNA polymerase 67 ACS 40 trypsin 39 ribonucleotide reductase 33 protein kinase 32 IMP dehydrogenase 31 ribonucleotide reductase 31 endonuclease 31 serine hydroxymethyltransferase 31 PTR1 31 topoisomerase 29 methylenetetrahydrofolate reductase 27 topoisomerase 26 ERK 25 methylenetetrahydrofolate reductase 25 P-glycoprotein 25 proteasome 25 luciferase 24 RNase 24 chloramphenicol acetyltransferase 23 reverse transcriptase 23 beta-lactamase 22 RNase 22 beta-galactosidase 22 GTP cyclohydrolase I 22 glutathione S-transferase 21 chaperonin 20 sepiapterin reductase 20 glycinamide ribonucleotide transformylase 19 methionine synthase 19 dihydropteridine reductase 18 lactate dehydrogenase 18 cytochrome oxidase 18 cdc2 17 ATPase 17 catalase 17 thrombin 16 HIV-1 protease 15 methionine synthase 15 NO synthase 15 adenosine deaminase 15 alkaline phosphatase 15 alcohol dehydrogenase 15 adenosine deaminase 14 aspartate transcarbamylase 14 superoxide dismutase 14 methylenetetrahydrofolate dehydrogenase 13 cyclohydrolase 13 focal adhesion kinase 13 ornithine decarboxylase 13 hypoxanthine-guanine phosphoribosyltransferase 13 aldehyde dehydrogenase 12 aldehyde dehydrogenase 12 ATP synthase 12 glutamine synthetase 12 chymotrypsin 12 phenylalanine hydroxylase 11 tissue plasminogen activator 11 NOS 11 protein kinase C 11 adenine phosphoribosyltransferase 11 dCMP deaminase 11 mitogen-activated protein kinase 10 firefly luciferase 10 aspartate aminotransferase 10 NADPH oxidase 10 S1 nuclease 10 phenylalanyl-tRNA synthetase 10 peroxidase 10 proteinase K 9 formyltetrahydrofolate synthetase 9 dUTPase 9 deoxyribonuclease 9 conjugase 9 more...

Compound DNA 1198 dihydrofolate 462 Dec 437 NADPH 391 NADPH 389 Methotrexate 328 pyrimidine 278 pyrimidine 273 hydrogen 186 NADP 160 glutamate 138 arginine 129 water 129 MTX 125 phosphate 121 pteridine 110 nicotinamide 107 Phe 103 ATP 98 leucine 97 methionine 96 Clin 95 urea 83 serine 80 glutamic acid 77 TMP 76 His 75 TMQ 74 sodium 73 lysine 71 alanine 69 PGA 68 tyrosine 68 folinic acid 65 Ile 65 tryptophan 61 salt 61 Trimethoprim 59 tryptophan 54 tryptophan 54 oxygen 54 MIC 54 tryptophan 54 threonine 53 bromide 51 Asp 51 cysteine 50 Pyrimethamine 49 quinazoline 48 quinazoline 48 Gly 48 NH2 46 SDS 46 sulfate 46 calcium 43 nitrogen 43 TMP 41 TMP 41 TMP 41 ACS 40 ACS 40 Trimetrexate 37 5-formyltetrahydrofolate 33 nitric oxide 33 PRPP 33 GTP 31 homocysteine 30 dUMP 30 ornithine 30 ornithine 30 ornithine 30 ornithine 30 ornithine 30 acetate 29 guanidine 29 pyridine 29 asparagine 27 glucose 26 valine 26 ZD1694 26 more...

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