Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.5.1.3 (dihydrofolate reductase)
5,819 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein dihydrofolate reductase 5221 DHFR 959 Mol 638 thymidylate synthase 598 Sep 445 NADPH 388 fused 174 NMR 168 reductase 161 Dihydrofolate reductase 153 MTX 125 thymidylate synthetase 125 polypeptide 124 ATP 98 NADP+ 89 folylpolyglutamate synthetase 87 hormone receptor 73 thymidine kinase 73 NADP 70 p53 67 glycinamide ribonucleotide formyltransferase 56 MIC 54 reduced folate carrier 51 c-myc 48 oxidoreductase 47 SDS 44 tRNA 42 TMP 41 ACS 40 Sp1 36 DNA polymerase 35 MTHFR 34 E2F1 33 glycoprotein 33 osteosarcoma 33 RNA polymerase II 32 dimeric 31 ribonucleotide reductase 31 endonuclease 31 RFC) 31 more...

Disease cancer 588 tumor 382 malaria 315 leukemia 230 CEM 88 breast cancer 82 carcinoma 76 Mycobacterium 71 AIDS 55 tuberculosis 54 pneumonia 49 MCF 47 HIV 47 hepatocellular carcinoma 44 SDS 44 acute lymphoblastic leukemia 39 carcinogenesis 38 retinoblastoma 36 osteosarcoma 36 myelosuppression 35 infectious diseases 34 Plasmodium falciparum malaria 34 adenocarcinoma 31 lymphoma 30 melanoma 30 rheumatoid arthritis 30 mesothelioma 29 lung cancer 29 cytomegalovirus 27 colorectal cancer 27 folate deficiency 26 non-small cell lung cancer 26 squamous cell carcinoma 26 toxoplasmosis 25 Leukemia 25 herpes simplex 25 PCP 25 colon cancer 24 immunodeficiency 22 lymphoblastic leukemia 22 more...

Symptom diarrhea 20 starvation 15 nausea and vomiting 8 collapse 8 vomiting 5 nausea 5 pain 4 seizures 2 ataxia 2 dystonia 2 erythema 2 weakness 2 fatigue 2 inanition 1 headache 1 splenomegaly 1 spasticity 1 DNA marker 1 exhaustion 1 agitation 1 dyspnea 1 abdominal pain 1 general problem 1 anesthesia 1 overweight 1 tremor 1 acidity 1 muscle rigidity 1 anorexia 1 HSA 1

Drug THF 260 Asn 72 lysine 51 Pemetrexed 45 BH4 37 ampicillin 34 G418 25 NADH 24 Alimta 18 DNase I 15 Gel 13 Leucovorin 12 Fansidar 12 Fansidar 12 IFN-gamma 11 CSF 10 Kenyan 9 Glide 8 ABC 8 IL-2 8 caffeine 7 Mutagen 7 Dermatol 7 CTX 6 Atovaquone 5 ICI 5 Pemetrexed disodium 5 Trimethoprim-sulfamethoxazole 5 lactose 5 Angiotensin II 4 ROS 4 Fragment 4 Gemzar 4 Fluorescein 4 CTX 4 Atovaquone 4 CTX 4 IFN-beta 4 GEO 4 Leaf 3 more...

Enzyme dihydrofolate reductase 5819 thymidylate synthase 702 dihydropteroate synthase 230 folylpolyglutamate synthetase 90 thymidine kinase 73 DNA polymerase 71 RNA polymerase 67 ACS 40 trypsin 39 ribonucleotide reductase 33 protein kinase 32 IMP dehydrogenase 31 ribonucleotide reductase 31 PTR1 31 serine hydroxymethyltransferase 31 endonuclease 31 topoisomerase 29 methylenetetrahydrofolate reductase 27 topoisomerase 26 proteasome 25 ERK 25 P-glycoprotein 25 methylenetetrahydrofolate reductase 25 RNase 24 luciferase 24 reverse transcriptase 23 chloramphenicol acetyltransferase 23 GTP cyclohydrolase I 22 beta-lactamase 22 RNase 22 beta-galactosidase 22 glutathione S-transferase 21 sepiapterin reductase 20 chaperonin 20 methionine synthase 19 glycinamide ribonucleotide transformylase 19 dihydropteridine reductase 18 cytochrome oxidase 18 lactate dehydrogenase 18 cdc2 17 more...

Compound DNA 1198 dihydrofolate 462 Dec 437 NADPH 391 NADPH 389 Methotrexate 328 pyrimidine 278 pyrimidine 273 hydrogen 186 NADP 160 glutamate 138 water 129 arginine 129 MTX 125 phosphate 121 pteridine 110 nicotinamide 107 Phe 103 ATP 98 leucine 97 methionine 96 Clin 95 urea 83 serine 80 glutamic acid 77 TMP 76 His 75 TMQ 74 sodium 73 lysine 71 alanine 69 tyrosine 68 PGA 68 folinic acid 65 Ile 65 salt 61 tryptophan 61 Trimethoprim 59 tryptophan 54 tryptophan 54 more...

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