Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.5.1.3 (dihydrofolate reductase)
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Human Gene/Protein
dihydrofolate reductase 0.897
DHFR 0.165
thymidylate synthase 0.021
Dihydrofolate reductase 0.012
glycinamide ribonucleotide formyltransferase 0.005
folylpolyglutamate synthetase 0.004
thymidylate synthetase 0.003
DHPS 0.001
MTX 0.001
reduced folate carrier 0.001
NADPH 0.001
folylpoly-gamma-glutamate synthetase 0.001
dihydrofolate reductase-like protein 1 0.001
NADP+ 0.001
sepiapterin reductase 0.000
dihydrofolate reductase-like 1 0.000
MTHFD1 0.000
DHFRP2 0.000
SHMT1 0.000
RING3-like protein 0.000
more...
Disease
malaria 0.000
CEM 0.000
Dihydrofolate reductase deficiency 0.000
R-binder deficiency 0.000
Plasmodium falciparum malaria 0.000
glutamate formiminotransferase deficiency 0.000
leukemia 0.000
methionine synthase deficiency 0.000
folate deficiency 0.000
cancer 0.000
Squamous Cell Cancer 0.000
transcobalamin II deficiency 0.000
ASSA 0.000
DA5 0.000
myelosuppression 0.000
tumor 0.000
Stenotrophomonas maltophilia infection 0.000
Ovary 0.000
AKE 0.000
DHPR deficiency 0.000
more...
Symptom
inanition 0.000
starvation 0.000
nausea and vomiting 0.000
diarrhea 0.000
general problem 0.000
DNA marker 0.000
muscle rigidity 0.000
collapse 0.000
nausea 0.000
HSA 0.000
vomiting 0.000
dystonia 0.000
erythema 0.000
spasticity 0.000
ataxia 0.000
splenomegaly 0.000
agitation 0.000
exhaustion 0.000
anorexia 0.000
acidity 0.000
more...
Drug
THF 0.001
Pemetrexed 0.001
Alimta 0.001
Met-Tyr-Gly 0.000
Pemetrexed disodium 0.000
BH4 0.000
Fansidar 0.000
Fansidar 0.000
Tmr 0.000
Pralatrexate 0.000
Asn 0.000
Trimetrexate glucuronate 0.000
Leucovorin 0.000
G418 0.000
7-Methylguanosine 0.000
Methotrexat 0.000
1,2,4-Triazole 0.000
Paraplatin 0.000
Forodesine 0.000
Atovaquone 0.000
more...
Enzyme
dihydrofolate reductase 1.000
thymidylate synthase 0.024
dihydropteroate synthase 0.017
folylpolyglutamate synthetase 0.004
PTR1 0.002
glycinamide ribonucleotide transformylase 0.000
sepiapterin reductase 0.000
serine hydroxymethyltransferase 0.000
dihydrofolate synthetase 0.000
formyltransferase, dihydrofolate 0.000
methylenetetrahydrofolate dehydrogenase 0.000
IMP dehydrogenase 0.000
Cpro-2 0.000
glutamate formiminotransferase 0.000
dihydropteridine reductase 0.000
dCMP hydroxymethylase 0.000
AICAR transformylase 0.000
dCMP deaminase 0.000
GTP cyclohydrolase I 0.000
blasticidin-S deaminase 0.000
more...
Compound
dihydrofolate 0.038
TMQ 0.006
Methotrexate 0.004
Trimetrexate 0.003
pteridine 0.003
Pyrimethamine 0.001
MTX 0.001
NADPH 0.001
NADPH 0.001
Trimethoprim 0.001
PRPP 0.001
6-(bromomethyl)-2,4-pteridinediamine 0.001
1843U89 0.001
pyrimidine 0.001
BW 301U 0.001
pyrimidine 0.001
Sulfadoxine 0.001
ZD1694 0.000
folinic acid 0.000
5-formyltetrahydrofolate 0.000
more...