Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.3 (dihydrofolate reductase)
 5,819 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
dihydrofolate reductase 12.4
DHFR 12.4
TAFII-105 12.4
dihydrofolate reductase-like 1 12.4
RING3-like protein 12.4
dihydrofolate reductase-like protein 1 12.1
Cholesterol 27-hydroxylase 11.4
HLA-SB beta 11.4
HCG1 11.4
SS18L2 11.4
Endothelial nitric oxidase synthase 11.4
DHFRP2 11.4
glycinamide ribonucleotide formyltransferase 11.3
Dihydrofolate reductase 11.3
DHPS 10.9
MRP-L20 10.8
TRAF interacting protein 10.8
mutS homolog 3 10.8
beta adaptin 10.8
folylpolyglutamate synthetase 10.5
more...
Disease
Dihydrofolate reductase deficiency 11.4
R-binder deficiency 10.8
glutamate formiminotransferase deficiency 10.1
methionine synthase deficiency 9.4
Squamous Cell Cancer 8.8
transcobalamin II deficiency 8.7
ASSA 8.7
DA5 8.6
Stenotrophomonas maltophilia infection 8.3
AKE 8.2
DHPR deficiency 7.9
cblF 7.6
Downbeat nystagmus 7.4
Diabetic gastroparesis 7.0
CEM 6.8
bacterial dysentery 6.7
Plasmodium falciparum malaria 6.5
XPE 6.5
Enzyme inhibition 6.4
folate deficiency 6.4
more...
Symptom
inanition 4.6
general problem 2.7
DNA marker 2.6
muscle rigidity 2.3
nausea and vomiting 2.2
starvation 1.7
diarrhea 0.9
HSA 0.9
collapse 0.6
dystonia 0.4
nausea 0.2
vomiting -0.2
spasticity -0.2
erythema -0.3
ataxia -0.5
splenomegaly -0.9
agitation -1.1
exhaustion -1.3
anorexia -1.3
acidity -1.5
more...
Drug
Met-Tyr-Gly 12.4
Alimta 10.3
Tmr 10.1
Pemetrexed disodium 9.6
Trimetrexate glucuronate 9.4
Pemetrexed 9.2
Pralatrexate 9.0
7-Methylguanosine 8.8
Methotrexat 8.4
1,2,4-Triazole 8.2
Fansidar 8.1
Fansidar 8.0
Forodesine 7.9
Paraplatin 7.9
THF 7.4
Thyrogen 7.4
Compound 18 7.2
TMX 7.1
Toltrazuril 7.1
BH4 7.1
more...
Enzyme
dihydrofolate reductase 12.4
formyltransferase, dihydrofolate 12.4
dihydropteroate synthase 11.2
blasticidin-S deaminase 10.8
PTR1 10.7
folylpolyglutamate synthetase 10.5
EC 2.7.4.4 10.4
Cpro-2 10.4
deoxynucleoside monophosphate kinase 10.1
3-N-aminoglycoside acetyltransferase 10.1
thymidylate synthase 10.1
glutamate formiminotransferase 10.0
dihydrofolate synthetase 9.8
glycinamide ribonucleotide transformylase 9.5
dCMP hydroxymethylase 9.5
sepiapterin reductase 9.2
AICAR transformylase 9.2
dCTPase 9.0
HPPK 9.0
5,10-methenyltetrahydrofolate synthetase 8.9
more...
Compound
Etoprine 12.4
Bisbrusatolyl malonate 12.4
2,4-diaminopyrido[2,3-d]pyrimidine-6-carbonitrile 12.4
6-(bromomethyl)-2,4-pteridinediamine 12.0
BW 301U 11.5
4-phenyl-1,2,4-triazolidine-3,5-dione 11.4
Tetrahydroneopterin 11.4
C9H10Cl2O2 11.4
C8H7N7 11.4
dihydrofolate 11.4
Trimetrexate 11.2
TMQ 11.2
C8H7N7 10.8
Homofolate 10.8
Microlenin 10.8
1843U89 10.8
Diaveridine 10.6
C4H4N2O2 10.4
5-bromotryptophan 10.4
tert-butyl cyanoacetate 10.4
more...