Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.3 (dihydrofolate reductase)
 5,819 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
dihydrofolate reductase 5221
DHFR 959
Mol 638
thymidylate synthase 598
Sep 445
NADPH 388
fused 174
NMR 168
reductase 161
Dihydrofolate reductase 153
MTX 125
thymidylate synthetase 125
polypeptide 124
ATP 98
NADP+ 89
folylpolyglutamate synthetase 87
hormone receptor 73
thymidine kinase 73
NADP 70
p53 67
more...
Disease
cancer 588
tumor 382
malaria 315
leukemia 230
CEM 88
breast cancer 82
carcinoma 76
Mycobacterium 71
AIDS 55
tuberculosis 54
pneumonia 49
HIV 47
MCF 47
hepatocellular carcinoma 44
SDS 44
acute lymphoblastic leukemia 39
carcinogenesis 38
osteosarcoma 36
retinoblastoma 36
myelosuppression 35
more...
Symptom
diarrhea 20
starvation 15
collapse 8
nausea and vomiting 8
vomiting 5
nausea 5
pain 4
fatigue 2
seizures 2
erythema 2
ataxia 2
dystonia 2
weakness 2
inanition 1
headache 1
splenomegaly 1
spasticity 1
DNA marker 1
exhaustion 1
agitation 1
more...
Drug
THF 260
Asn 72
lysine 51
Pemetrexed 45
BH4 37
ampicillin 34
G418 25
NADH 24
Alimta 18
DNase I 15
Gel 13
Leucovorin 12
Fansidar 12
Fansidar 12
IFN-gamma 11
CSF 10
Kenyan 9
IL-2 8
ABC 8
Glide 8
more...
Enzyme
dihydrofolate reductase 5819
thymidylate synthase 702
dihydropteroate synthase 230
folylpolyglutamate synthetase 90
thymidine kinase 73
DNA polymerase 71
RNA polymerase 67
ACS 40
trypsin 39
ribonucleotide reductase 33
protein kinase 32
IMP dehydrogenase 31
serine hydroxymethyltransferase 31
PTR1 31
ribonucleotide reductase 31
endonuclease 31
topoisomerase 29
methylenetetrahydrofolate reductase 27
topoisomerase 26
ERK 25
more...
Compound
DNA 1198
dihydrofolate 462
Dec 437
NADPH 391
NADPH 389
Methotrexate 328
pyrimidine 278
pyrimidine 273
hydrogen 186
NADP 160
glutamate 138
arginine 129
water 129
MTX 125
phosphate 121
pteridine 110
nicotinamide 107
Phe 103
ATP 98
leucine 97
more...