Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.3 (dihydrofolate reductase)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
dihydrofolate reductase 0.897
DHFR 0.165
thymidylate synthase 0.021
Dihydrofolate reductase 0.012
glycinamide ribonucleotide formyltransferase 0.005
folylpolyglutamate synthetase 0.004
thymidylate synthetase 0.003
DHPS 0.001
MTX 0.001
reduced folate carrier 0.001
NADPH 0.001
folylpoly-gamma-glutamate synthetase 0.001
dihydrofolate reductase-like protein 1 0.001
NADP+ 0.001
sepiapterin reductase 0.000
dihydrofolate reductase-like 1 0.000
MTHFD1 0.000
DHFRP2 0.000
SHMT1 0.000
RING3-like protein 0.000
TAFII-105 0.000
SLC19A1 0.000
purH 0.000
dihydropteridine reductase 0.000
RFC) 0.000
RFC1 0.000
serine hydroxymethyltransferase 0.000
SS18L2 0.000
Cholesterol 27-hydroxylase 0.000
HCG1 0.000
Endothelial nitric oxidase synthase 0.000
HLA-SB beta 0.000
reductase 0.000
TYMS 0.000
methylenetetrahydrofolate dehydrogenase 0.000
MTHFR 0.000
TMP 0.000
dCMP deaminase 0.000
MTR 0.000
mutS homolog 3 0.000
TRAF interacting protein 0.000
MRP-L20 0.000
beta adaptin 0.000
hormone receptor 0.000
OVCA2 0.000
thymidine kinase 0.000
MTHFD2 0.000
NADP 0.000
COPG1 0.000
SSXT 0.000
MnSOD precursor 0.000
TGF-beta activated kinase 0.000
Mol 0.000
serine hydroxymethyltransferase 1 0.000
folate binding protein 0.000
GAR transformylase 0.000
C12orf35 0.000
HIP1 protein 0.000
ACTR1A 0.000
TAFII105 0.000
RING3 protein 0.000
cytoplasmic serine hydroxymethyltransferase 0.000
Sepiapterin reductase 0.000
fused 0.000
MTRR 0.000
COXIV 0.000
60kD 0.000
RPF2 0.000
C1-tetrahydrofolate synthase 0.000
TFDP1 0.000
SQM1 0.000
PHS2 0.000
DNA polymerase alpha 0.000
E2F1 0.000
E2F-1 0.000
NFRKB 0.000
GCH 0.000
RAPGEF6 0.000
RAB1 0.000
ATIC 0.000
FTCD 0.000
Cytochrome c oxidase subunit II 0.000
solute carrier family 19 member 1 0.000
TBP associated factor 0.000
DYR 0.000
SRRF 0.000
PDXDC1 0.000
delta globin 0.000
Serine hydroxymethyltransferase 0.000
serine hydroxymethyltransferase 2 0.000
HB3 0.000
MSH3 0.000
GADD45 gamma 0.000
I-TRAF 0.000
NADPH oxidase organizer 1 0.000
PSMD13 0.000
L-alanine:glyoxylate aminotransferase 0.000
ribonucleotide reductase 0.000
dUTPase 0.000
thymidine kinase-1 0.000
Formiminotransferase-cyclodeaminase 0.000
dipeptidyl peptidase 9 0.000
MAST4 0.000
MTHFS 0.000
FOLR1 0.000
SEC13 0.000
methionine synthase 0.000
6-pyruvoyltetrahydropterin synthase 0.000
methylenetetrahydrofolate reductase 0.000
SS18L1 0.000
FOXJ3 0.000
TSase 0.000
IFN-alpha 5 0.000
delta-globin 0.000
oxidoreductase 0.000
SRPR 0.000
UFD2 0.000
FKBP-25 0.000
E2F-5 0.000
ribosomal protein L36 0.000
ALDH1L2 0.000
p107 0.000
RING3 0.000
SHMT2 0.000
methylenetetrahydrofolate dehydrogenase 1 0.000
GTP cyclohydrolase I 0.000
AICARFT 0.000
CDH8 0.000
HLA-DP beta 0.000
MOLT 0.000
c-myc 0.000
F56 0.000
MAN1A1 0.000
TFDP2 0.000
HUG1 0.000
E2F-2 0.000
polypeptide 0.000
32kD 0.000
PSME2 0.000
HSSB 0.000
ubiquitin-like protein FAT10 0.000
TIM44 0.000
chaperonin 0.000
hGH 0.000
FOLR3 0.000
MXRA5 0.000
ATPase subunit 9 0.000
NGX6 0.000
HSA5 0.000
syndecan 2 0.000
IARS 0.000
VPH1 0.000
NMR 0.000
Sp1 0.000
GroES 0.000
GABRE 0.000
50kD 0.000
E2F4 0.000
Rpn6 0.000
TAOK1 0.000
more...
Disease
malaria 0.000
CEM 0.000
Dihydrofolate reductase deficiency 0.000
R-binder deficiency 0.000
Plasmodium falciparum malaria 0.000
glutamate formiminotransferase deficiency 0.000
leukemia 0.000
methionine synthase deficiency 0.000
folate deficiency 0.000
cancer 0.000
Squamous Cell Cancer 0.000
ASSA 0.000
transcobalamin II deficiency 0.000
DA5 0.000
myelosuppression 0.000
tumor 0.000
Stenotrophomonas maltophilia infection 0.000
Ovary 0.000
AKE 0.000
DHPR deficiency 0.000
lymphoblastic leukemia 0.000
cblF 0.000
mesothelioma 0.000
retinoblastoma 0.000
Ovary 0.000
cryptosporidiosis 0.000
Downbeat nystagmus 0.000
Mycobacterium 0.000
Enzyme inhibition 0.000
PCP 0.000
toxoplasmosis 0.000
Diabetic gastroparesis 0.000
osteosarcoma 0.000
MCF 0.000
xeroderma pigmentosum 0.000
acute lymphoblastic leukemia 0.000
bacterial dysentery 0.000
Shigella sonnei 0.000
Cockayne syndrome 0.000
childhood ALL 0.000
choriocarcinoma 0.000
XPE 0.000
mouse leukemia L1210 0.000
hyperphenylalaninemia 0.000
stage III colorectal cancer 0.000
isosporiasis 0.000
pneumonia 0.000
Leukemia 0.000
Condensation 0.000
breast cancer 0.000
VRSA 0.000
SDS 0.000
tuberculosis 0.000
carcinoma 0.000
DSH 0.000
sarcoma 180 0.000
African trypanosomiasis 0.000
leishmaniasis 0.000
pediatric solid tumor 0.000
Choriocarcinoma 0.000
orotic aciduria 0.000
non-small cell lung cancer 0.000
acute monocytic leukemia 0.000
hepatocellular carcinoma 0.000
megaloblastic anemia 0.000
opportunistic infection 0.000
cytomegalovirus 0.000
LIS1 0.000
AIDS 0.000
solid tumor 0.000
MPS IIIA 0.000
MRSA 0.000
erythroleukemia 0.000
Shaver 0.000
TTP 0.000
herpes simplex 0.000
carcinogenesis 0.000
Chagas 0.000
fibrosarcoma 0.000
SAR 0.000
colon cancer 0.000
Rous sarcoma 0.000
coprophagy 0.000
lung carcinoma 0.000
AT3 0.000
ARH 0.000
AT3 0.000
AT3 0.000
AT3 0.000
AT3 0.000
AT3 0.000
AT3 0.000
AT3 0.000
AT3 0.000
Plasmodium vivax infection 0.000
nagana 0.000
pharyngotonsillitis 0.000
leukopenia 0.000
Kaposi's sarcoma 0.000
MAC 0.000
neutropenia 0.000
rheumatoid arthritis 0.000
TNS 0.000
PDB 0.000
Parvovirus B19 infection 0.000
melioidosis 0.000
epithelial ovarian cancer 0.000
Shigella boydii 0.000
TTP 0.000
squamous cell carcinoma 0.000
Tropical Diseases 0.000
familial Alzheimer disease 0.000
gastrointestinal disease 0.000
adenocarcinoma 0.000
Shigella dysenteriae 0.000
colorectal cancer 0.000
refractory cancer 0.000
infectious diseases 0.000
Sanfilippo 0.000
T-cell acute lymphoblastic leukemia 0.000
psoriasis 0.000
abdominal aortic aneurysm 0.000
HMS 0.000
Infection 0.000
melanoma 0.000
CMD 0.000
EL4 0.000
CMD 0.000
HIV 0.000
riboflavin deficiency 0.000
primary hyperoxaluria 0.000
lymphoma 0.000
vitamin B12 deficiency 0.000
adenocarcinoma of the colon 0.000
primary central nervous system lymphoma 0.000
FIM 0.000
fits 0.000
HEP 0.000
lung cancer 0.000
RP4 0.000
drug usage 0.000
AIDS-related Kaposi's sarcoma 0.000
NS4 0.000
anthrax 0.000
AAA 0.000
Plasmodium falciparum infection 0.000
trophoblastic tumor 0.000
Breast carcinoma 0.000
PDR 0.000
Larsen 0.000
Superinfection 0.000
phenylketonuria 0.000
sarcoma 0.000
hyperhomocysteinemia 0.000
acute leukemia 0.000
mole 0.000
Leigh syndrome 0.000
glioma 0.000
APOB 0.000
juvenile rheumatoid arthritis 0.000
more...
Symptom
inanition 0.000
starvation 0.000
nausea and vomiting 0.000
diarrhea 0.000
general problem 0.000
DNA marker 0.000
muscle rigidity 0.000
collapse 0.000
nausea 0.000
HSA 0.000
vomiting 0.000
dystonia 0.000
erythema 0.000
spasticity 0.000
ataxia 0.000
splenomegaly 0.000
agitation 0.000
exhaustion 0.000
anorexia 0.000
acidity 0.000
weakness 0.000
tremor 0.000
fatigue 0.000
overweight 0.000
dyspnea 0.000
abdominal pain 0.000
seizures 0.000
pain 0.000
headache 0.000
anesthesia 0.000
Drug
THF 0.001
Pemetrexed 0.001
Alimta 0.001
Met-Tyr-Gly 0.000
Pemetrexed disodium 0.000
BH4 0.000
Fansidar 0.000
Fansidar 0.000
Tmr 0.000
Pralatrexate 0.000
Asn 0.000
Trimetrexate glucuronate 0.000
Leucovorin 0.000
G418 0.000
7-Methylguanosine 0.000
Methotrexat 0.000
1,2,4-Triazole 0.000
Paraplatin 0.000
Forodesine 0.000
Atovaquone 0.000
Atovaquone 0.000
Compound 18 0.000
Gemzar 0.000
Glide 0.000
Thyrogen 0.000
TMX 0.000
Trimethoprim-sulfamethoxazole 0.000
Toltrazuril 0.000
Orthoclone OKT3 0.000
Bactrim 0.000
Allegra 0.000
Allegra 0.000
Amprolium 0.000
ampicillin 0.000
Folic Acid 0.000
Malarone 0.000
Navelbine 0.000
lysine 0.000
Compound 16 0.000
Isoprinosine 0.000
Compound 15 0.000
Trypanothione 0.000
Doripenem 0.000
DNase I 0.000
Dihydro 0.000
Pertuzumab 0.000
Kenyan 0.000
NADH 0.000
Artesunate 0.000
FSH-beta 0.000
Dithranol 0.000
Trib 0.000
Vinorelbine 0.000
AGG 0.000
ARA-C 0.000
Miltefosine 0.000
Primaquine 0.000
GEO 0.000
Compound 9 0.000
Propidium 0.000
Ketotifen 0.000
Gel 0.000
Arsenic trioxide 0.000
Ergosterol 0.000
Meth 0.000
Mycophenolic acid 0.000
Fragment 0.000
Mutagen 0.000
TRM 0.000
Oxaliplatin 0.000
CTT 0.000
Isoniazid 0.000
ABC 0.000
MEA 0.000
Epigallocatechin 0.000
OMP 0.000
IFN-beta 0.000
Clofibrate 0.000
Lovastatin 0.000
ICI 0.000
Fluorescein 0.000
TAT 0.000
Urokinase 0.000
ETS 0.000
Fluorescein 0.000
Alanine 0.000
OTC 0.000
PMEA 0.000
Erlotinib 0.000
Campath 0.000
Campath 0.000
Riboflavin 0.000
TEL 0.000
IFN-gamma 0.000
Rosiglitazone 0.000
Angiotensin II 0.000
Pravastatin 0.000
TTC 0.000
CTX 0.000
BoNT/A 0.000
CTX 0.000
Amoxicillin 0.000
CTX 0.000
DEX 0.000
Dakar 0.000
Cetuximab 0.000
ACT 0.000
NVP 0.000
GRF 0.000
Omeprazole 0.000
Prednisone 0.000
CSF 0.000
AraC 0.000
OTC 0.000
FLP 0.000
Nitric Oxide 0.000
Vitamin B 0.000
Pronase 0.000
Fluconazole 0.000
ZnCl2 0.000
ZnCl2 0.000
G-CSF 0.000
NBT 0.000
BLM 0.000
caffeine 0.000
FAD 0.000
Taxol 0.000
IL-2 0.000
Gleevec 0.000
Bortezomib 0.000
VCR 0.000
CPR 0.000
PTC 0.000
NH3 0.000
lactose 0.000
CPT-11 0.000
Itraconazole 0.000
ADR 0.000
Frontal 0.000
Adriamycin 0.000
-deoxyadenosine 0.000
uPA 0.000
EPI 0.000
DMI 0.000
MDS 0.000
Herceptin 0.000
Glycerol 0.000
TMS 0.000
CDP 0.000
Imatinib 0.000
pyridoxal phosphate 0.000
HCG 0.000
ETA 0.000
ROS 0.000
MRC 0.000
Biopolymers 0.000
p75 0.000
MAP 0.000
Albumin 0.000
Glutathione 0.000
more...
Enzyme
dihydrofolate reductase 1.000
thymidylate synthase 0.024
dihydropteroate synthase 0.017
folylpolyglutamate synthetase 0.004
PTR1 0.002
glycinamide ribonucleotide transformylase 0.000
sepiapterin reductase 0.000
serine hydroxymethyltransferase 0.000
dihydrofolate synthetase 0.000
formyltransferase, dihydrofolate 0.000
methylenetetrahydrofolate dehydrogenase 0.000
IMP dehydrogenase 0.000
Cpro-2 0.000
glutamate formiminotransferase 0.000
dihydropteridine reductase 0.000
dCMP hydroxymethylase 0.000
AICAR transformylase 0.000
dCMP deaminase 0.000
GTP cyclohydrolase I 0.000
blasticidin-S deaminase 0.000
deoxynucleoside monophosphate kinase 0.000
thymidine kinase 0.000
formyltetrahydrofolate synthetase 0.000
EC 2.7.4.4 0.000
methylenetetrahydrofolate dehydrogenase 0.000
3-N-aminoglycoside acetyltransferase 0.000
dCTPase 0.000
cyclohydrolase 0.000
carboxypeptidase G2 0.000
methionine synthase 0.000
HPPK 0.000
ribonucleotide reductase 0.000
methylenetetrahydrofolate reductase 0.000
5,10-methenyltetrahydrofolate synthetase 0.000
ribonucleotide reductase 0.000
conjugase 0.000
dihydroorotase 0.000
phenylalanyl-tRNA synthetase 0.000
methylenetetrahydrofolate reductase 0.000
methionine synthase 0.000
DNA polymerase 0.000
aromatic amine dehydrogenase 0.000
aspartate transcarbamylase 0.000
dUTPase 0.000
thymidylate kinase 0.000
enoyl-ACP reductase 0.000
D-aminopeptidase 0.000
enoyl-ACP reductase 0.000
adenine phosphoribosyltransferase 0.000
chaperonin 0.000
aminoglycoside adenylyltransferase 0.000
6-pyruvoyltetrahydropterin synthase 0.000
streptomycin adenylyltransferase 0.000
malyl-CoA lyase 0.000
uridine hydrolase 0.000
orotidine-5'-phosphate decarboxylase 0.000
aminoglycoside 6'-N-acetyltransferase 0.000
alpha-1,4-glucan lyase 0.000
adenosine nucleosidase 0.000
L-asparagine synthetase 0.000
RNA polymerase 0.000
amidophosphoribosyltransferase 0.000
methionine synthase reductase 0.000
HIV-1 protease 0.000
chloramphenicol acetyltransferase 0.000
Streptomyces griseus protease B 0.000
phenylalanine hydroxylase 0.000
GAR 0.000
endothiapepsin 0.000
dCTP deaminase 0.000
p-hydroxybenzoate hydroxylase 0.000
kynurenine formamidase 0.000
topoisomerase 0.000
D-amino acid aminotransferase 0.000
rhodanese 0.000
cytidine deaminase 0.000
alpha-lytic protease 0.000
topoisomerase 0.000
dihydropyrimidine dehydrogenase 0.000
dihydroneopterin aldolase 0.000
hypoxanthine-guanine phosphoribosyltransferase 0.000
CTP synthase 0.000
dihydroorotate dehydrogenase 0.000
dihydroorotate dehydrogenase 0.000
GMP reductase 0.000
GMP synthase 0.000
deoxyribonuclease 0.000
dihydropyrimidine dehydrogenase 0.000
cytosine deaminase 0.000
MetE 0.000
carboxypeptidase D 0.000
thymidine phosphorylase 0.000
pantothenate synthetase 0.000
Tpt1 0.000
hygromycin B phosphotransferase 0.000
p-hydroxybenzoate hydroxylase 0.000
10-formyltetrahydrofolate dehydrogenase 0.000
glycine N-methyltransferase 0.000
endonuclease 0.000
Dm-dNK 0.000
xanthine phosphoribosyltransferase 0.000
nicotinic acid phosphoribosyltransferase 0.000
homocysteine methyltransferase 0.000
P-glycoprotein 0.000
adenosine deaminase 0.000
aldehyde oxidase 0.000
benzoylformate decarboxylase 0.000
bleomycin hydrolase 0.000
triose-phosphate isomerase 0.000
chorismate synthase 0.000
plasmepsin II 0.000
adenosine deaminase 0.000
firefly luciferase 0.000
uracil phosphoribosyltransferase 0.000
nicotinamide phosphoribosyltransferase 0.000
STK2 0.000
adenylosuccinate synthetase 0.000
cytochrome oxidase 0.000
xanthine dehydrogenase 0.000
beta-lactamase 0.000
cdc2 0.000
alpha-isopropylmalate synthase 0.000
methylthioadenosine phosphorylase 0.000
guanase 0.000
trypsin 0.000
PRPP synthetase 0.000
beta-galactosidase 0.000
isoleucyl-tRNA synthetase 0.000
spermidine/spermine N1-acetyltransferase 0.000
transcarboxylase 0.000
RNase 0.000
glutamine synthetase 0.000
Escherichia coli exonuclease III 0.000
methylamine dehydrogenase 0.000
S1 nuclease 0.000
aldehyde dehydrogenase 0.000
farnesyltransferase 0.000
RNase 0.000
glutamate racemase 0.000
asparagine synthetase 0.000
hydroxynitrile lyase 0.000
ornithine decarboxylase 0.000
hydroxynitrile lyase 0.000
Thy1 0.000
uridine phosphorylase 0.000
thiopurine methyltransferase 0.000
carbamoylphosphate synthetase 0.000
endodeoxyribonuclease 0.000
micrococcal nuclease 0.000
CPS 0.000
CTD kinase 0.000
alanine racemase 0.000
phosphoglycerate dehydrogenase 0.000
alcohol dehydrogenase 0.000
endonuclease V 0.000
UMP kinase 0.000
prostasin 0.000
GMP synthetase 0.000
hydroxynitrile lyase 0.000
aldehyde dehydrogenase 0.000
more...
Compound
dihydrofolate 0.038
TMQ 0.006
Methotrexate 0.004
Trimetrexate 0.003
pteridine 0.003
Pyrimethamine 0.001
MTX 0.001
NADPH 0.001
NADPH 0.001
Trimethoprim 0.001
PRPP 0.001
6-(bromomethyl)-2,4-pteridinediamine 0.001
1843U89 0.001
pyrimidine 0.001
BW 301U 0.001
pyrimidine 0.001
Sulfadoxine 0.001
ZD1694 0.000
folinic acid 0.000
5-formyltetrahydrofolate 0.000
NADP 0.000
2,4-diaminopyrido[2,3-d]pyrimidine-6-carbonitrile 0.000
TMP 0.000
Aminopterin 0.000
DNA 0.000
DDMP 0.000
Proguanil 0.000
dUMP 0.000
Dihydropteroate 0.000
Etoprine 0.000
Bisbrusatolyl malonate 0.000
quinazoline 0.000
quinazoline 0.000
10-formyltetrahydrofolate 0.000
PGA 0.000
Tetrahydroneopterin 0.000
C8H7N7 0.000
C9H10Cl2O2 0.000
4-phenyl-1,2,4-triazolidine-3,5-dione 0.000
Diaveridine 0.000
TMP 0.000
TMP 0.000
TMP 0.000
Microlenin 0.000
Homofolate 0.000
C8H7N7 0.000
Sepiapterin 0.000
nicotinamide 0.000
tert-butyl cyanoacetate 0.000
C4H4N2O2 0.000
5-bromotryptophan 0.000
10-formyldihydrofolate 0.000
CH3-THF 0.000
Cirsilineol 0.000
2-Aminopyrimidine 0.000
C20H24O6 0.000
2-(tert-butylamino)ethanol 0.000
Chloroquinoxaline sulfonamide 0.000
ethyl isocyanatoacetate 0.000
N-methylbenzenesulfonamide 0.000
5,10-methylene-THF 0.000
Conformer B 0.000
Baker's Antifol 0.000
2-cyanoacetohydrazide 0.000
5,10-methenyltetrahydrofolate 0.000
7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 0.000
cTMP 0.000
4-pyrimidinol 0.000
DHF 0.000
glutamic acid 0.000
6-Methyluracil 0.000
Tetrahydrobiopterin 0.000
methyl 4-formylbenzoate 0.000
7,8-Dihydrobiopterin 0.000
NAAAF 0.000
2-methylquinoxaline 0.000
7-Methylguanosine 0.000
2-butanone oxime 0.000
6-fluorotryptophan 0.000
2,4-Diamino-6-hydroxypyrimidine 0.000
2,4-pyrimidinediamine 0.000
6-pyruvoyltetrahydropterin 0.000
glutamate 0.000
6R-BH4 0.000
Thymidine 0.000
1,3,5-triazine-2,4-diamine 0.000
TTP 0.000
ethyl trifluoroacetate 0.000
ethyl trifluoroacetate 0.000
1,2,3-trimethoxybenzene 0.000
Phe 0.000
Ile 0.000
MTA 0.000
2-Acetylpyridine 0.000
Diaminopyridine 0.000
6-Azauridine 0.000
4-methyleneglutamic acid 0.000
7H-pyrrolo[2,3-d]pyrimidine 0.000
Biopterin 0.000
arginine 0.000
1-naphthalenesulfonic acid 0.000
1-naphthalenesulfonic acid 0.000
hydrogen 0.000
(aminooxy)acetic acid 0.000
1-benzothiophene 0.000
methionine 0.000
leucine 0.000
Sulfamethoxazole 0.000
MIC 0.000
1,3-dichloroacetone 0.000
ornithine 0.000
ornithine 0.000
ornithine 0.000
ornithine 0.000
ornithine 0.000
1,3-dichloroacetone 0.000
Liriodenine 0.000
dichloropalladium 0.000
4,6-dichloropyrimidine 0.000
Isethionate 0.000
Acetylshikonin 0.000
GAR 0.000
bis(2-chloroethyl) 0.000
urea 0.000
Sulfathiazole 0.000
Sulfamylon 0.000
tert-butyl carbamate 0.000
serine 0.000
1,3,5-triazine 0.000
FUDR 0.000
1,3,5-triazine 0.000
THF 0.000
guanidine 0.000
aminoacetic acid 0.000
aminoacetic acid 0.000
aminoacetic acid 0.000
dCTP 0.000
M1A 0.000
Cyromazine 0.000
tryptophan 0.000
aminoacetic acid 0.000
Dec 0.000
BAF 0.000
tryptophan 0.000
tryptophan 0.000
phosphate 0.000
tryptophan 0.000
Mezerein 0.000
homocysteine 0.000
aminoacetic acid 0.000
9,10-dihydroacridine 0.000
Asp 0.000
Sulfonamide 0.000
dUDP 0.000
H4MPT 0.000
Leucovorin 0.000
ATP 0.000
His 0.000
Gly 0.000
alanine 0.000
more...