Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.3 (dihydrofolate reductase)
 5,819 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
dihydrofolate reductase 5221
DHFR 959
Mol 638
thymidylate synthase 598
Sep 445
NADPH 388
fused 174
NMR 168
reductase 161
Dihydrofolate reductase 153
MTX 125
thymidylate synthetase 125
polypeptide 124
ATP 98
NADP+ 89
folylpolyglutamate synthetase 87
hormone receptor 73
thymidine kinase 73
NADP 70
p53 67
glycinamide ribonucleotide formyltransferase 56
MIC 54
reduced folate carrier 51
c-myc 48
oxidoreductase 47
SDS 44
tRNA 42
TMP 41
ACS 40
Sp1 36
DNA polymerase 35
MTHFR 34
glycoprotein 33
osteosarcoma 33
E2F1 33
RNA polymerase II 32
RFC) 31
endonuclease 31
dimeric 31
ribonucleotide reductase 31
GTP 30
DNA polymerase alpha 29
ubiquitin 28
ras 28
Gen 27
housekeeping 27
endoplasmic reticulum 26
cytochrome 26
precursor protein 25
P-glycoprotein 25
interferon 25
proteasome 24
methylenetetrahydrofolate reductase 24
DHPS 24
Pseudomonas 23
NAD 22
NADH 22
serine hydroxymethyltransferase 21
cyclin A 21
Met 21
E2F-1 20
chaperonin 20
nitric oxide synthase 20
sepiapterin reductase 20
membrane protein 20
B12 20
AMP 19
metallothionein 19
cyclin 19
histone 19
insulin 19
c-fos 19
MOLT 18
cytokine 18
dihydropteridine reductase 18
MTR 18
lactate dehydrogenase 18
cytochrome b 18
hGH 18
pseudogene 17
threonine 17
RNase 17
MTRR 17
epidermal growth factor receptor 17
methionine synthase 16
folylpoly-gamma-glutamate synthetase 16
heavy chain 16
p21 16
cryptic 16
SOD 16
thrombin 16
p107 15
cyclin E 15
GroES 15
ATPase 15
DNA gyrase 15
ADP 15
MDR1 15
chimeric protein 15
UTR 15
alkaline phosphatase 15
DNase I 15
albumin 15
CD34 14
adenosine deaminase 14
folate receptor 14
beta-actin 14
proliferating cell nuclear antigen 14
surface antigen 14
dUTPase 13
endothelial nitric oxide synthase 13
lymphoid 13
glutathione S-transferase 13
serum albumin 13
ornithine decarboxylase 13
TYMS 13
MTHFD1 13
methyltransferase 12
tyrosine kinase 12
SLC19A1 12
P-gp 12
purH 12
caspase-3 12
K12 12
cyclin D1 12
RFC1 12
c-Myc 12
Bcl-2 12
superoxide dismutase 12
integrase 12
methylenetetrahydrofolate dehydrogenase 12
SAR 12
alcohol dehydrogenase 12
IFN-gamma 12
dCMP deaminase 11
TEM 11
microsomal 11
chymotrypsin 11
vascular endothelial growth factor 11
phenylalanine hydroxylase 11
ara 11
SHMT1 11
cytochrome c 11
catalase 11
pRb 11
PLA 11
heat shock protein 11
glutamine synthetase 11
Pol 11
estrogen receptor 10
MRSA 10
transcription factor Sp1 10
IFN 10
colon carcinoma 10
unknown function 10
NTP 10
proto-oncogene 10
cyclin-dependent kinase 10
GST 10
PEG 10
more...
Disease
cancer 588
tumor 382
malaria 315
leukemia 230
CEM 88
breast cancer 82
carcinoma 76
Mycobacterium 71
AIDS 55
tuberculosis 54
pneumonia 49
HIV 47
MCF 47
hepatocellular carcinoma 44
SDS 44
acute lymphoblastic leukemia 39
carcinogenesis 38
retinoblastoma 36
osteosarcoma 36
myelosuppression 35
Plasmodium falciparum malaria 34
infectious diseases 34
adenocarcinoma 31
lymphoma 30
melanoma 30
rheumatoid arthritis 30
lung cancer 29
mesothelioma 29
cytomegalovirus 27
colorectal cancer 27
squamous cell carcinoma 26
non-small cell lung cancer 26
folate deficiency 26
herpes simplex 25
toxoplasmosis 25
Leukemia 25
PCP 25
colon cancer 24
Infection 22
lymphoblastic leukemia 22
immunodeficiency 22
lung carcinoma 21
leishmaniasis 20
fits 19
metastases 19
glioma 17
neutropenia 17
sarcoma 16
cold 16
cryptosporidiosis 16
thrombocytopenia 16
psoriasis 16
tumor growth 15
acute myeloid leukemia 15
choriocarcinoma 15
Klebsiella 14
xeroderma pigmentosum 14
Ovary 14
hepatitis B 14
anemia 14
multiple myeloma 14
Epstein 14
Ovary 14
diabetes 13
epithelial ovarian cancer 13
mole 13
arthritis 13
hypertension 13
solid tumor 13
Chagas 13
mole 13
rash 12
Kaposi's sarcoma 12
childhood ALL 12
fibrosarcoma 12
SAR 12
ovarian cancer 11
leukopenia 11
tumor progression 11
TEM 11
TEM 11
MRSA 10
PDB 10
hepatitis C 10
abdominal aortic aneurysm 10
opportunistic infection 9
erythroleukemia 9
acute leukemia 9
MAC 9
chronic myeloid leukemia 9
African trypanosomiasis 9
bladder cancer 9
glioblastoma 8
pancreatic cancer 8
Shigella sonnei 8
Cockayne syndrome 8
stomatitis 8
acute promyelocytic leukemia 7
mammary tumor 7
depression 7
metastatic breast cancer 7
Haemophilus 7
coronary artery disease 7
SEM 7
Shigella 7
atherosclerosis 7
Rous sarcoma 7
neuroblastoma 6
sepsis 6
cardiovascular disease 6
DDP 6
gastrointestinal disease 6
SCID 6
malnutrition 6
suicide 6
anthrax 6
ATM 6
influenza 6
Infections 6
West 6
diphtheria 6
Condensation 6
cholera 6
Wright 5
stroke 5
T-cell acute lymphoblastic leukemia 5
AAA 5
gonococcal 5
virus infection 5
megaloblastic anemia 5
GSH 5
melioidosis 5
TTP 5
hyperphenylalaninemia 5
ischemia 5
DBA 5
leprosy 5
plaque 5
gastric cancer 5
tumorigenesis 5
head and neck cancer 5
TTP 5
sarcoma 180 5
hyperhomocysteinemia 5
phenylketonuria 5
dehydration 5
prostate cancer 5
Mycoplasma 5
Yersinia 5
Chlamydia 5
aggressiveness 4
cervical cancer 4
renal cancer 4
Adenovirus 4
neoplastic transformation 4
respiratory infection 4
Parkinson's disease 4
primary tumor 4
vaccinia 4
plasmacytoma 4
more...
Symptom
diarrhea 20
starvation 15
nausea and vomiting 8
collapse 8
vomiting 5
nausea 5
pain 4
seizures 2
ataxia 2
dystonia 2
erythema 2
weakness 2
fatigue 2
inanition 1
headache 1
splenomegaly 1
spasticity 1
DNA marker 1
exhaustion 1
agitation 1
dyspnea 1
abdominal pain 1
general problem 1
anesthesia 1
overweight 1
tremor 1
acidity 1
muscle rigidity 1
anorexia 1
HSA 1
Drug
THF 260
Asn 72
lysine 51
Pemetrexed 45
BH4 37
ampicillin 34
G418 25
NADH 24
Alimta 18
DNase I 15
Gel 13
Leucovorin 12
Fansidar 12
Fansidar 12
IFN-gamma 11
CSF 10
Kenyan 9
IL-2 8
Glide 8
ABC 8
Mutagen 7
caffeine 7
Dermatol 7
CTX 6
Pemetrexed disodium 5
ICI 5
Trimethoprim-sulfamethoxazole 5
lactose 5
Atovaquone 5
ROS 4
GEO 4
CTX 4
Angiotensin II 4
Fragment 4
CTX 4
Gemzar 4
Fluorescein 4
Atovaquone 4
IFN-beta 4
TAT 3
FAD 3
AGG 3
ETS 3
NH3 3
Bactrim 3
Alanine 3
Trib 3
MAP 3
Leaf 3
Fluorescein 3
Meth 3
Compound 18 3
Pralatrexate 3
Arsenic trioxide 3
Dihydro 3
G-CSF 3
Methotrexat 2
Oxaliplatin 2
Taxol 2
Adriamycin 2
TMX 2
Navelbine 2
Paraplatin 2
TTC 2
Lovastatin 2
Artesunate 2
ACT 2
Isoniazid 2
Dakar 2
ascorbate 2
Biopolymers 2
Nitric Oxide 2
Vinorelbine 2
Propidium 1
7-Methylguanosine 1
Met-Tyr-Gly 1
uPA 1
PMEA 1
EE2 1
Allegra 1
ADR 1
CTT 1
Clofibrate 1
PTC 1
ROC 1
Riboflavin 1
Vitamin B 1
Gleevec 1
Imatinib 1
Ergosterol 1
1,2,4-Triazole 1
Allegra 1
Albumin 1
p75 1
Ketotifen 1
Glycerol 1
Trimetrexate glucuronate 1
Omeprazole 1
Primaquine 1
Herceptin 1
CPT-11 1
Itraconazole 1
GRF 1
NVP 1
-deoxyadenosine 1
BLM 1
Prednisone 1
ARA-C 1
VCR 1
Erlotinib 1
TMS 1
AraC 1
Compound 16 1
Miltefosine 1
MDS 1
Pronase 1
pyridoxal phosphate 1
Compound 9 1
Glutathione 1
ZnCl2 1
OTC 1
MEA 1
Compound 15 1
Tmr 1
Fluconazole 1
Frontal 1
Rosiglitazone 1
Amprolium 1
citric acid 1
Campath 1
TEL 1
Forodesine 1
CAM 1
OTC 1
ZnCl2 1
Epigallocatechin 1
OMP 1
Mycophenolic acid 1
Campath 1
Isoprinosine 1
ETA 1
DEX 1
Trypanothione 1
Cardiovasc 1
Pertuzumab 1
Monit 1
NBT 1
Amoxicillin 1
CDP 1
Orthoclone OKT3 1
CPR 1
Malarone 1
EPI 1
FLP 1
Ethanol 1
Dithranol 1
Thyrogen 1
Toltrazuril 1
TRM 1
DMI 1
more...
Enzyme
dihydrofolate reductase 5819
thymidylate synthase 702
dihydropteroate synthase 230
folylpolyglutamate synthetase 90
thymidine kinase 73
DNA polymerase 71
RNA polymerase 67
ACS 40
trypsin 39
ribonucleotide reductase 33
protein kinase 32
endonuclease 31
IMP dehydrogenase 31
ribonucleotide reductase 31
PTR1 31
serine hydroxymethyltransferase 31
topoisomerase 29
methylenetetrahydrofolate reductase 27
topoisomerase 26
ERK 25
proteasome 25
methylenetetrahydrofolate reductase 25
P-glycoprotein 25
RNase 24
luciferase 24
reverse transcriptase 23
chloramphenicol acetyltransferase 23
GTP cyclohydrolase I 22
RNase 22
beta-galactosidase 22
beta-lactamase 22
glutathione S-transferase 21
sepiapterin reductase 20
chaperonin 20
glycinamide ribonucleotide transformylase 19
methionine synthase 19
cytochrome oxidase 18
dihydropteridine reductase 18
lactate dehydrogenase 18
cdc2 17
ATPase 17
catalase 17
thrombin 16
HIV-1 protease 15
NO synthase 15
alcohol dehydrogenase 15
adenosine deaminase 15
alkaline phosphatase 15
methionine synthase 15
superoxide dismutase 14
adenosine deaminase 14
aspartate transcarbamylase 14
focal adhesion kinase 13
hypoxanthine-guanine phosphoribosyltransferase 13
ornithine decarboxylase 13
methylenetetrahydrofolate dehydrogenase 13
cyclohydrolase 13
glutamine synthetase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
ATP synthase 12
chymotrypsin 12
NOS 11
tissue plasminogen activator 11
phenylalanine hydroxylase 11
protein kinase C 11
dCMP deaminase 11
adenine phosphoribosyltransferase 11
firefly luciferase 10
mitogen-activated protein kinase 10
aspartate aminotransferase 10
NADPH oxidase 10
phenylalanyl-tRNA synthetase 10
S1 nuclease 10
peroxidase 10
proteinase K 9
conjugase 9
dUTPase 9
dihydroorotase 9
formyltetrahydrofolate synthetase 9
caspase-3 9
deoxyribonuclease 9
xanthine oxidase 8
carboxypeptidase G2 8
dihydrofolate synthetase 8
NADPH oxidase 8
dihydropyrimidine dehydrogenase 8
micrococcal nuclease 8
lysozyme 8
cytidine deaminase 8
dihydropyrimidine dehydrogenase 7
aldehyde dehydrogenase 7
CAD 7
MDR 7
glyceraldehyde-3-phosphate dehydrogenase 7
CAD 7
thymidine phosphorylase 7
CAD 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
thymidylate kinase 7
rhodanese 7
methylenetetrahydrofolate dehydrogenase 7
neuraminidase 7
xanthine dehydrogenase 6
ACE 6
farnesyltransferase 6
hexokinase 6
orotidine-5'-phosphate decarboxylase 6
tyrosinase 6
malate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
glucose-6-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
cytosine deaminase 6
AICAR transformylase 6
phosphodiesterase 6
glyceraldehyde-3-phosphate dehydrogenase 6
deaminase 6
ribonuclease 5
ribonuclease 5
enoyl-ACP reductase 5
Thy1 5
acid phosphatase 5
dihydroorotate dehydrogenase 5
APC 5
thioredoxin reductase 5
glutathione reductase 5
PARP 5
acetylcholinesterase 5
diaphorase 5
thromboplastin 5
CPR 5
dihydroorotate dehydrogenase 5
purine nucleoside phosphorylase 5
NQO1 5
ornithine transcarbamylase 5
CPS 5
adenylate kinase 5
enoyl-ACP reductase 5
aldehyde oxidase 5
dCMP hydroxymethylase 5
thermolysin 5
carboxypeptidase A 4
farnesyltransferase 4
phosphorylase 4
furin 4
urokinase-type plasminogen activator 4
aldose reductase 4
ricin 4
6-phosphogluconate dehydrogenase 4
6-phosphogluconate dehydrogenase 4
MPP 4
prostate-specific membrane antigen 4
CD10 4
sulfatase 4
succinate dehydrogenase 4
transpeptidase 4
lipoxygenase 4
more...
Compound
DNA 1198
dihydrofolate 462
Dec 437
NADPH 391
NADPH 389
Methotrexate 328
pyrimidine 278
pyrimidine 273
hydrogen 186
NADP 160
glutamate 138
water 129
arginine 129
MTX 125
phosphate 121
pteridine 110
nicotinamide 107
Phe 103
ATP 98
leucine 97
methionine 96
Clin 95
urea 83
serine 80
glutamic acid 77
TMP 76
His 75
TMQ 74
sodium 73
lysine 71
alanine 69
tyrosine 68
PGA 68
folinic acid 65
Ile 65
salt 61
tryptophan 61
Trimethoprim 59
MIC 54
tryptophan 54
tryptophan 54
tryptophan 54
oxygen 54
threonine 53
bromide 51
Asp 51
cysteine 50
Pyrimethamine 49
Gly 48
quinazoline 48
quinazoline 48
SDS 46
NH2 46
sulfate 46
nitrogen 43
calcium 43
TMP 41
TMP 41
TMP 41
ACS 40
ACS 40
Trimetrexate 37
nitric oxide 33
5-formyltetrahydrofolate 33
PRPP 33
GTP 31
ornithine 30
homocysteine 30
ornithine 30
ornithine 30
dUMP 30
ornithine 30
ornithine 30
acetate 29
pyridine 29
guanidine 29
asparagine 27
valine 26
glucose 26
ZD1694 26
NAD 25
THF 24
TTP 24
NADH 24
ammonium 23
aspartic acid 23
isoleucine 22
aspartic acid 22
aspartic acid 22
glutamine 22
NAD 22
proline 22
aspartic acid 22
DEAE 21
isoleucine 21
COS 19
Sulfadoxine 18
ADP 18
uridine 18
MDA 17
Thymidine 17
THF 16
ADP 15
ADP 15
PEG 15
methanol 15
5-FU 15
potassium 14
10-formyltetrahydrofolate 14
TEM 14
MTA 14
zinc 14
galactose 13
copper 13
Guo 13
iodine 13
aldehyde 13
ethanol 12
DHF 12
alcohol dehydrogenase 12
MTT 12
PEG 12
HCl 12
benzoic acid 12
bis(2-chloroethyl) 12
dCTP 11
1,3,5-triazine 11
CH3-THF 11
aldehyde 11
1843U89 11
glycerol 11
hydroxide 11
A 1 11
1,3,5-triazine 11
benzene 11
dATP 10
DDP 10
quinoline 10
DDMP 10
Tetrahydrobiopterin 10
quinoline 10
PDB 10
hydroxylamine 10
hydroxylamine 9
Proguanil 9
ammonia 9
fluorine 9
AMP 9
Aminopterin 9
5,10-methenyltetrahydrofolate 8
boron 8
silver 8
CTP 8
acrylamide 8
DMF 8
CAM 8
CO2 8
DMSO 8
Sulfamethoxazole 8
cAMP 8
more...