Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.5.1.3 (
dihydrofolate reductase
)
5,819
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Using the methods of ion exchange and paper chromatography, the content of d-UMP, AMP, GMP, and UMP was measured in 13-15 day rat embryos, and the changes in the pools of these nucleotides under the action of chloridin, one of the inhibitors of
dihydrofolate reductase
, were also determined. Only the concentration of d-UMP changed appreciably: it increased in the case of normal development from the 13th to the 14th day, apralleling a decrease in the specific activity of
TMS
, and especially sharply under the action of chloridin, which, inhibiting
dihydrofolate reductase
, evidently created a deficiency of FA-H4 and thereby blocked the
TMS
reaction.
...
PMID:Changes in the pool of deoxyuridine monophosphate in the normal embryogenesis of rats and under the influence of the folic acid antagonist chloridin. 112 38
