Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.5.1.3 (
dihydrofolate reductase
)
5,819
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In an attempt to clarify the role of beta interferon in vitro cell systems, the metabolic expression of
dihydrofolate reductase
(
DHFR
), succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH), by histochemical methods was studied.
DHFR
was also quantified by flow cytometry.
Glioblastoma
cell line with or without beta interferon was used. Three days after the treatment the
DHFR
reaction was much less intense than in the control. Quantitative data confirmed these results. Immediately afterwards, most cells exhibited much more intense reaction. These facts underlined that, in this biological model in vitro, beta interferon could reduce the synthesis of these enzymes only for a short period.
...
PMID:[Qualitative and quantitative histochemical evaluation of the dehydrogenase activity in human glioblastoma cells treated with beta-interferon]. 237 36
