Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.5.1.3 (
dihydrofolate reductase
)
5,819
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two mitochondrial ribosomal proteins, YmL13 and
MRP7
, of the yeast Saccharomyces cerevisiae and their derivatives were synthesized in vitro and their transport into isolated yeast mitochondria was examined. Both proteins were transported into yeast mitochondria in an energy-dependent manner.
MRP7
protein was transported even when its N-terminal presequence was deleted, and the N-terminal presequence alone was not capable of transporting a fused passenger protein, Chinese hamster
DHFR
. YmL13 protein, on the other hand, was not transported without its N-terminal presequence, and its presequence was capable of transporting Chinese hamster
DHFR
into mitochondria. Thus,
MRP7
appears to possess a transport signal in its mature part, while YmL13 possesses a signal only in its N-terminal presequence.
...
PMID:Transport of mitoribosomal proteins, YmL13 and MRP7, into isolated mitochondria of Saccharomyces cerevisiae. 822 Feb 40
