Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.5.1.3 (
dihydrofolate reductase
)
5,819
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The response of hemopoietic and/or
lymphosarcoma
cells to methotrexate has been investigated. The proliferative capacity of hemopoietic tissue was measured by exogenous CFU assay. It was inhibited by a six times lower amount of MTX than the proliferative activity of
lymphosarcoma
cells as evaluated by liver-colony assay. The natural resistance of LS/BL
lymphosarcoma
cells to MTX might be attributed to the
DHFR
gene amplification resulting from DNA rearrangements appearing during malignant transformation.
...
PMID:The cytotoxic effect of methotrexate as evaluated by colony-forming activity of hemopoietic and tumor cells. 321 32
