Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.20 (methylenetetrahydrofolate reductase)
 2,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
methylenetetrahydrofolate reductase 2013
5,10-methylenetetrahydrofolate reductase 299
MTHFR 233
prothrombin 193
Mol 172
B12 165
factor V Leiden 162
Sep 152
methionine synthase 150
methionine synthase reductase 94
factor V 87
MTRR 83
thymidylate synthase 82
MTR 71
cystathionine beta-synthase 63
protein C 63
protein S 56
plasminogen activator inhibitor-1 53
reduced folate carrier 45
plasminogen activator inhibitor 40
methylenetetrahydrofolate dehydrogenase 33
fibrinogen 33
antithrombin 33
reductase 30
methyltransferase 28
apolipoprotein E 27
dihydrofolate reductase 26
Methylenetetrahydrofolate reductase 25
antithrombin III 23
CBS 23
insulin 21
Polymerase 20
C-reactive protein 18
SAM 17
UTR 17
serine hydroxymethyltransferase 17
She 17
dihydropyrimidine dehydrogenase 17
glutathione S-transferase 17
factor VIII 17
glycoprotein 16
cystathionine-beta-synthase 16
HDL 16
FAD 15
NADPH 15
endothelial nitric oxide synthase 15
MTHFD1 15
MRI 14
B-12 14
RFC 13
SLC19A1 13
GSTT1 13
hemoglobin 13
thrombin 12
apolipoprotein 12
ANOVA 12
NADH 12
RFC1 12
GSTM1 12
factor VII 11
angiotensinogen 11
5-methyltetrahydrofolate-homocysteine methyltransferase 11
catechol-O-methyltransferase 10
p53 10
CRP 10
Met 10
FOLR1 10
TYMS 10
Lp(a) 10
thymidylate synthetase 10
albumin 10
APOE 9
GSTP1 9
plasminogen 9
glycoprotein IIIa 8
eNOS 8
flavoprotein 8
cytokine 8
RFC) 8
transcobalamin II 8
more...
Disease
hyperhomocysteinemia 328
cancer 234
stroke 163
cardiovascular disease 126
vascular disease 92
atherosclerosis 92
coronary artery disease 85
hypertension 83
colorectal cancer 75
tumor 69
folate deficiency 59
breast cancer 59
acute lymphoblastic leukemia 59
diabetes 58
carcinogenesis 56
homocystinuria 55
schizophrenia 53
myocardial infarction 48
deep vein thrombosis 39
preeclampsia 38
Down syndrome 35
Alzheimer's disease 35
systemic lupus erythematosus 34
abortion 32
lupus 31
lymphoma 31
renal disease 30
lupus 30
obesity 27
childhood ALL 27
rheumatoid arthritis 25
dementia 25
migraine 24
gastric cancer 22
pulmonary embolism 22
leukemia 21
Thrombophilia 20
coronary heart disease 20
colon cancer 19
osteoporosis 19
cognitive impairment 18
vitamin B12 deficiency 17
male infertility 17
metabolic syndrome 17
cleft palate 16
lung cancer 16
infertility 16
type 2 diabetes 16
Parkinson's disease 15
carcinoma 15
malnutrition 14
acute myocardial infarction 14
adenoma 14
depression 14
sickle cell disease 14
epilepsy 14
anemia 13
diabetic nephropathy 13
heart disease 13
renal failure 13
developmental delay 12
essential hypertension 12
bipolar disorder 12
hepatocellular carcinoma 11
cerebral infarction 11
tumorigenesis 10
psychosis 10
megaloblastic anemia 10
squamous cell carcinoma 10
arteriosclerosis 9
cirrhosis 9
fits 9
eclampsia 9
adenocarcinoma 9
autism 9
plaque 9
genetic disorder 8
transient ischemic attack 8
bladder cancer 8
polycystic ovary syndrome 8
more...
Symptom
headache 18
seizures 16
overweight 10
pain 8
hypotonia 5
fatigue 5
ataxia 5
vomiting 5
abdominal pain 5
weakness 5
tremor 4
angina 4
nausea 4
spasm 3
paraparesis 3
spasticity 3
dysarthria 3
dyspnea 2
chest pain 2
numbness 2
cough 2
metamorphopsia 1
hemoptysis 1
anesthesia 1
hand pain 1
hypothermia 1
limb pain 1
photophobia 1
pallor 1
hepatomegaly 1
cachexia 1
hypertonia 1
paresis 1
stigma 1
anorexia 1
neck pain 1
cyanosis 1
lethargy 1
diarrhea 1
insomnia 1
photopsia 1
dizziness 1
memory loss 1
inanition 1
Decreased activity 1
hemiplegia 1
Livedoid 1
Drug
THF 31
FAD 15
Vitamin B12 15
NADH 12
Cardiovasc 10
pyridoxal phosphate 9
CSF 6
lysine 5
Vitamin B 5
Fragment 4
Monit 4
vitamin E 3
Nephron 3
ascorbate 3
Cobalamin 3
Dermatol 2
CTX 2
Bevacizumab 2
Hakka 2
Nephron 2
Folic Acid 2
CTX 1
CTA 1
DDAVP 1
Gemfibrozil 1
MDS 1
Asn 1
CTX 1
Indomethacin 1
Pyridoxal 1
GVG 1
TEL 1
niacin 1
Arsenic trioxide 1
Lamisil 1
IL-2 1
Fructose 1
DDAVP 1
TAC 1
Fluorescein 1
Deoxyadenosine 1
Ethanol 1
ICI 1
AZT 1
Amiloride 1
Pemetrexed 1
ENT 1
Oxaliplatin 1
Portal 1
Paraffin 1
Fluorescein 1
PTH 1
ROS 1
Leucovorin 1
Troglitazone 1
Riboflavin 1
Lamisil 1
Leaf 1
Simvastatin 1
AZT 1
Enzyme
methylenetetrahydrofolate reductase 2134
methylenetetrahydrofolate reductase 2116
methionine synthase 155
methionine synthase 147
methionine synthase reductase 89
thymidylate synthase 83
APC 80
cystathionine beta-synthase 63
methylenetetrahydrofolate dehydrogenase 33
dihydrofolate reductase 27
methylenetetrahydrofolate dehydrogenase 26
ACE 22
serine hydroxymethyltransferase 19
glutathione S-transferase 18
homocysteine methyltransferase 18
cyclohydrolase 17
dihydropyrimidine dehydrogenase 17
methionine adenosyltransferase 16
dihydropyrimidine dehydrogenase 15
formyltetrahydrofolate synthetase 13
thrombin 12
NQO1 9
thiopurine methyltransferase 8
aldehyde dehydrogenase 8
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
ERK 7
tissue plasminogen activator 7
aldehyde dehydrogenase 7
aspartate aminotransferase 6
betaine-homocysteine methyltransferase 6
cystathionine gamma-synthase 6
paraoxonase 5
calcineurin 5
paraoxonase 5
glutathione reductase 5
phosphatidylethanolamine N-methyltransferase 5
renin 4
MetE 4
glycine N-methyltransferase 4
endonuclease 4
superoxide dismutase 4
thymidine phosphorylase 4
DNA methyltransferase 4
cystathionine gamma-lyase 4
ATPase 4
folylpolyglutamate synthetase 4
lipase 4
peroxidase 3
AGT 3
P-glycoprotein 3
diaphorase 3
cholesterol acyltransferase 3
alkaline phosphatase 3
alcohol dehydrogenase 3
conjugase 3
CAD 3
furin 3
carboxypeptidase G2 3
PTA 3
10-formyltetrahydrofolate dehydrogenase 3
UDP-glucuronosyltransferase 3
glucose-6-phosphate dehydrogenase 3
prostate-specific membrane antigen 3
5,10-methenyltetrahydrofolate synthetase 3
focal adhesion kinase 3
choline dehydrogenase 3
methionyl-tRNA synthetase 3
thromboplastin 3
CAD 3
proprotein convertase 3
asparaginase 3
subtilisin 3
CAD 3
glutathione peroxidase 2
lactate dehydrogenase 2
catalase 2
lysyl oxidase 2
protein phosphatase 2A 2
more...
Compound
homocysteine 785
DNA 340
methionine 251
Dec 168
Clin 161
PGA 127
Homocysteine 83
Homocysteine 83
adenosylmethionine 74
betaine 47
alanine 45
creatinine 37
valine 28
Cardiol 25
CBS 23
S-adenosylhomocysteine 23
glucose 21
water 21
Methotrexate 20
serine 20
cysteine 20
oxygen 18
His 16
FAD 16
NADPH 15
NADPH 15
CH3-THF 13
nitric oxide 13
NADH 12
calcium 12
Pac 12
sodium 11
phosphate 11
acetate 11
5,10-methenyltetrahydrofolate 10
TMP 10
glutamate 10
Methionine 10
Choline 8
nicotinamide 8
NAD 8
urea 8
folinic acid 8
arginine 8
5-FU 8
dUMP 8
5-formyltetrahydrofolate 7
lysine 7
NAD 7
hydrogen 7
vitamin D 7
formaldehyde 7
ethanol 7
formaldehyde 6
threonine 5
sulfate 5
H2S 5
CO2 5
NADP 5
nicotinic acid 5
ATP 5
leucine 5
pyrimidine 5
pyrimidine 5
Hemoglobin 4
Valproic acid 4
THF 4
Gly 4
uridine 4
iron 4
tryptophan 4
tryptophan 4
Asp 4
dihydrofolate 4
aldosterone 4
tryptophan 4
tryptophan 4
zinc 4
PDT 3
Cholesterol 3
more...