Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.20 (methylenetetrahydrofolate reductase)
 2,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
cholesteryl ester transfer protein, plasma 13.9
5,10-methylenetetrahydrofolate reductase 13.9
methylenetetrahydrofolate reductase 13.9
adrenergic, beta-3-, receptor 13.9
CDK5 regulatory subunit associated protein 1 13.9
intrinsic factor-vitamin B12 receptor 12.9
methionine synthase reductase 12.6
5-methyltetrahydrofolate-homocysteine methyltransferase 12.4
Leukocyte immunoglobulin-like receptor A3 12.3
alpha-1A-adrenergic receptor 12.3
serine hydroxymethyltransferase 1 12.2
glutathione S-transferase class theta 11.9
cytoplasmic serine hydroxymethyltransferase 11.6
methylenetetrahydrofolate dehydrogenase 11.3
FTHFD 11.3
Cytosolic serine hydroxymethyltransferase 11.3
methionine synthase 11.3
MTHFR 11.2
MTR 11.2
MTHFD1 11.1
solute carrier family 6 member 4 11.1
methylenetetrahydrofolate dehydrogenase 1 11.1
MTRR 11.0
solute carrier family 19 member 1 10.9
cystathionine-beta-synthase 10.9
MTHFS 10.8
CNTNAP4 10.7
LCMT1 10.7
reduced folate carrier 10.7
TCN2 10.6
AGTRAP 10.5
SLC19A1 10.5
cystathionine beta-synthase 10.4
factor V Leiden 10.4
Partitioning defective 3-like protein 10.4
SHMT1 10.3
formyltetrahydrofolate dehydrogenase 10.2
methionine adenosyltransferase II 10.2
RFC1 10.2
Methylenetetrahydrofolate reductase 10.1
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Disease
Dihydrofolate reductase deficiency 12.9
adult meningioma 11.9
Factor II mutation 11.9
glutamate formiminotransferase deficiency 11.5
methionine synthase deficiency 11.5
Mesenteric infarction 10.9
Placental infarction 10.7
hyperhomocysteinemia 10.6
CBS deficiency 10.2
homocystinemia 10.0
NFLD 10.0
Left main coronary artery disease 9.9
homocystinuria 9.8
Factor V Leiden mutation 9.7
Activated protein C resistance 9.6
Primary angle-closure glaucoma 9.3
Bipolar II disorder 9.1
cblF 9.1
folate deficiency 9.0
Thrombophilia 9.0
Imerslund 9.0
vitamin B deficiency 8.3
cystathioninuria 8.0
colon neoplasm 8.0
Lymphoblastic lymphoma 7.8
vitamin B12 deficiency 7.7
Protein S deficiency 7.7
choline deficiency 7.6
MEST 7.5
Acute encephalopathy 7.5
PC deficiency 7.5
Cerebral venous thrombosis 7.5
Central retinal artery occlusion 7.5
trisomy 2 7.5
mesenteric thrombosis 7.4
childhood NHL 7.4
childhood ALL 7.3
Retinal vein occlusion 7.3
riboflavin deficiency 7.2
Migraine with aura 7.2
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Symptom
Livedoid 8.2
photopsia 6.8
hand pain 6.2
inanition 6.1
metamorphopsia 5.9
Decreased activity 4.8
limb pain 4.5
paraparesis 4.0
hypotonia 3.7
hypertonia 3.6
dysarthria 3.6
photophobia 3.2
spasticity 2.8
spasm 2.6
pallor 2.6
numbness 2.5
overweight 2.5
headache 2.3
ataxia 2.2
memory loss 2.0
cyanosis 2.0
neck pain 1.9
hemiplegia 1.9
tremor 1.7
seizures 1.6
angina 1.5
cachexia 1.4
lethargy 1.4
hepatomegaly 1.4
paresis 1.4
nausea 1.3
hemoptysis 1.3
abdominal pain 1.3
vomiting 1.2
weakness 1.0
chest pain 0.8
dizziness 0.6
fatigue 0.5
insomnia 0.5
cough 0.3
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Drug
Folic Acid 8.9
Hakka 8.6
Lamisil 7.7
Lamisil 7.6
Vitamin B12 7.5
Cobalamin 7.4
Deoxyadenosine 6.9
GVG 6.5
Vitamin B 5.9
Pyridoxal 5.8
THF 5.8
pyridoxal phosphate 5.7
Gemfibrozil 5.5
FAD 5.3
Pemetrexed 5.2
Leucovorin 4.9
Troglitazone 4.8
Fragment 4.7
Riboflavin 4.3
TEL 4.3
Bevacizumab 4.1
Oxaliplatin 4.0
DDAVP 4.0
DDAVP 3.9
Arsenic trioxide 3.5
CTA 3.4
TAC 3.2
Simvastatin 3.2
Amiloride 3.0
NADH 3.0
Fructose 3.0
Paraffin 2.8
MDS 2.7
AZT 2.5
Fluorescein 2.5
AZT 2.3
Fluorescein 2.0
niacin 2.0
Portal 1.8
CTX 1.6
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Enzyme
methylenetetrahydrofolate reductase 13.9
methylenetetrahydrofolate reductase 13.9
methionine synthase reductase 12.7
methylenetetrahydrofolate dehydrogenase 11.8
methylenetetrahydrofolate dehydrogenase 11.7
methionine synthase 11.4
methionine synthase 11.3
5,10-methenyltetrahydrofolate synthetase 10.9
homocysteine methyltransferase 10.7
formyltetrahydrofolate synthetase 10.4
MetE 9.9
cystathionine beta-synthase 9.9
glutamate formiminotransferase 9.9
10-formyltetrahydrofolate dehydrogenase 9.3
cyclohydrolase 9.2
choline dehydrogenase 9.2
betaine-homocysteine methyltransferase 9.1
AICAR transformylase 9.1
cystathionine gamma-synthase 9.0
serine hydroxymethyltransferase 8.9
homoserine transacetylase 8.8
formylmethanofuran dehydrogenase 8.8
dimethylglycine dehydrogenase 8.6
glycine N-methyltransferase 8.6
caffeoyl-CoA O-methyltransferase 8.5
methionine adenosyltransferase 8.4
thymidylate synthase 8.4
phosphatidylethanolamine N-methyltransferase 8.4
dihydropyrimidine dehydrogenase 8.1
sarcosine dehydrogenase 8.1
carboxypeptidase G2 7.9
histone-lysine N-methyltransferase 7.9
thiopurine methyltransferase 7.8
dihydropyrimidine dehydrogenase 7.7
glycinamide ribonucleotide transformylase 7.7
CSAD 7.6
bleomycin hydrolase 7.5
folylpolyglutamate synthetase 7.4
nicotinamide N-methyltransferase 7.3
conjugase 7.3
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Compound
Menoctone 11.9
homocysteine 10.0
Homocysteine 9.9
Homocysteine 9.9
CH3-THF 9.7
5,10-methenyltetrahydrofolate 9.7
5,10-Methylenetetrahydrofolate 8.9
5,10-methylene-THF 8.9
PGA 8.7
Diamant 8.5
Thiouracil 8.3
Tetrahydrocurcumin 8.2
5-formyltetrahydrofolate 7.9
10-formyltetrahydrofolate 7.8
Benazepril 7.8
dUMP 7.5
Cobalamin 7.4
betaine 7.2
adenosylmethionine 7.0
Deoxyadenosine 7.0
S-adenosylhomocysteine 7.0
Cystathionine 6.7
C 10 6.7
C 10 6.7
Cystathionine 6.7
TCN 6.6
CBS 6.5
11-dehydro-thromboxane 6.3
Methionine 6.2
folinic acid 6.1
Choline 6.0
methionine 6.0
dihydrofolate 6.0
Methotrexate 5.9
Pyridoxal 5.8
TMP 5.7
Bantu 5.7
Glycine, 5.6
pentosidine 5.6
TIB 5.5
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