Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.20 (methylenetetrahydrofolate reductase)
2,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
methylenetetrahydrofolate reductase 2013
5,10-methylenetetrahydrofolate reductase 299
MTHFR 233
prothrombin 193
Mol 172
B12 165
factor V Leiden 162
Sep 152
methionine synthase 150
methionine synthase reductase 94
factor V 87
MTRR 83
thymidylate synthase 82
MTR 71
protein C 63
cystathionine beta-synthase 63
protein S 56
plasminogen activator inhibitor-1 53
reduced folate carrier 45
plasminogen activator inhibitor 40
more...
Disease
hyperhomocysteinemia 328
cancer 234
stroke 163
cardiovascular disease 126
atherosclerosis 92
vascular disease 92
coronary artery disease 85
hypertension 83
colorectal cancer 75
tumor 69
folate deficiency 59
breast cancer 59
acute lymphoblastic leukemia 59
diabetes 58
carcinogenesis 56
homocystinuria 55
schizophrenia 53
myocardial infarction 48
deep vein thrombosis 39
preeclampsia 38
more...
Symptom
headache 18
seizures 16
overweight 10
pain 8
abdominal pain 5
weakness 5
ataxia 5
hypotonia 5
vomiting 5
fatigue 5
nausea 4
angina 4
tremor 4
dysarthria 3
paraparesis 3
spasm 3
spasticity 3
dyspnea 2
chest pain 2
numbness 2
more...
Drug
THF 31
Vitamin B12 15
FAD 15
NADH 12
Cardiovasc 10
pyridoxal phosphate 9
CSF 6
lysine 5
Vitamin B 5
Fragment 4
Monit 4
Cobalamin 3
Nephron 3
vitamin E 3
ascorbate 3
Hakka 2
Dermatol 2
Folic Acid 2
Bevacizumab 2
Nephron 2
more...
Enzyme
methylenetetrahydrofolate reductase 2134
methylenetetrahydrofolate reductase 2116
methionine synthase 155
methionine synthase 147
methionine synthase reductase 89
thymidylate synthase 83
APC 80
cystathionine beta-synthase 63
methylenetetrahydrofolate dehydrogenase 33
dihydrofolate reductase 27
methylenetetrahydrofolate dehydrogenase 26
ACE 22
serine hydroxymethyltransferase 19
glutathione S-transferase 18
homocysteine methyltransferase 18
cyclohydrolase 17
dihydropyrimidine dehydrogenase 17
methionine adenosyltransferase 16
dihydropyrimidine dehydrogenase 15
formyltetrahydrofolate synthetase 13
more...
Compound
homocysteine 785
DNA 340
methionine 251
Dec 168
Clin 161
PGA 127
Homocysteine 83
Homocysteine 83
adenosylmethionine 74
betaine 47
alanine 45
creatinine 37
valine 28
Cardiol 25
CBS 23
S-adenosylhomocysteine 23
glucose 21
water 21
cysteine 20
Methotrexate 20
more...