Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.5.1.20 (
methylenetetrahydrofolate reductase
)
2,134
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
methylenetetrahydrofolate reductase
2013
5,10-methylenetetrahydrofolate reductase
299
MTHFR
233
prothrombin
193
Mol
172
B12
165
factor V Leiden
162
Sep
152
methionine synthase
150
methionine synthase reductase
94
factor V
87
MTRR
83
thymidylate synthase
82
MTR
71
protein C
63
cystathionine beta-synthase
63
protein S
56
plasminogen activator inhibitor-1
53
reduced folate carrier
45
plasminogen activator inhibitor
40
more...
Disease
hyperhomocysteinemia
328
cancer
234
stroke
163
cardiovascular disease
126
atherosclerosis
92
vascular disease
92
coronary artery disease
85
hypertension
83
colorectal cancer
75
tumor
69
folate deficiency
59
breast cancer
59
acute lymphoblastic leukemia
59
diabetes
58
carcinogenesis
56
homocystinuria
55
schizophrenia
53
myocardial infarction
48
deep vein thrombosis
39
preeclampsia
38
more...
Symptom
headache
18
seizures
16
overweight
10
pain
8
abdominal pain
5
weakness
5
ataxia
5
hypotonia
5
vomiting
5
fatigue
5
nausea
4
angina
4
tremor
4
dysarthria
3
paraparesis
3
spasm
3
spasticity
3
dyspnea
2
chest pain
2
numbness
2
more...
Drug
THF
31
Vitamin B12
15
FAD
15
NADH
12
Cardiovasc
10
pyridoxal phosphate
9
CSF
6
lysine
5
Vitamin B
5
Fragment
4
Monit
4
Cobalamin
3
Nephron
3
vitamin E
3
ascorbate
3
Hakka
2
Dermatol
2
Folic Acid
2
Bevacizumab
2
Nephron
2
more...
Enzyme
methylenetetrahydrofolate reductase
2134
methylenetetrahydrofolate reductase
2116
methionine synthase
155
methionine synthase
147
methionine synthase reductase
89
thymidylate synthase
83
APC
80
cystathionine beta-synthase
63
methylenetetrahydrofolate dehydrogenase
33
dihydrofolate reductase
27
methylenetetrahydrofolate dehydrogenase
26
ACE
22
serine hydroxymethyltransferase
19
glutathione S-transferase
18
homocysteine methyltransferase
18
cyclohydrolase
17
dihydropyrimidine dehydrogenase
17
methionine adenosyltransferase
16
dihydropyrimidine dehydrogenase
15
formyltetrahydrofolate synthetase
13
more...
Compound
homocysteine
785
DNA
340
methionine
251
Dec
168
Clin
161
PGA
127
Homocysteine
83
Homocysteine
83
adenosylmethionine
74
betaine
47
alanine
45
creatinine
37
valine
28
Cardiol
25
CBS
23
S-adenosylhomocysteine
23
glucose
21
water
21
cysteine
20
Methotrexate
20
more...