Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.19 (NOS)
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Human Gene/Protein
Rap guanine nucleotide exchange factor (GEF) 1 12.1
Dihydropyrimidinase-like 3 11.5
DPYSL3 protein 11.1
ZBTB44 11.1
60S ribosomal protein L7 11.1
FHL-3 11.1
2P domain potassium channel 10.5
eukaryotic translation initiation factor 4E nuclear import factor 1 10.5
poliovirus receptor-related 3 10.5
NK2 transcription factor related locus 5 10.5
ACCN2 10.5
NOS III 10.4
Constitutive NOS 10.3
CGRP-RCP 10.1
nNOSmu 9.9
NOS-1 9.8
Multiple inositol polyphosphate phosphatase 9.8
DDAH 9.8
constitutive nitric oxide synthase 9.8
PFTAIRE protein kinase 1 9.5
RLA1 9.5
SNAP1 9.5
neuronal nitric oxide synthase 9.5
NOS1 protein 9.4
NOS1 9.3
PDZ-GEF2 9.3
TEX1 9.3
GCH1 protein 9.1
LRRN3 9.1
eNOS 9.1
DDAH-1 9.1
EMBP 8.9
AGT-1 8.9
sodium-coupled branched-chain amino-acid transporter 1 8.9
LUC7L 8.9
NOS3 8.9
Endothelial nitric oxide synthase 8.9
REL protein 8.8
NTKL 8.8
INOS 8.8
AAMP 8.8
alanine-glyoxylate aminotransferase 2 8.8
caveolin-2 protein 8.8
RAY1 8.8
dimethylarginine dimethylaminohydrolase 1 8.7
nitric oxide synthase 1 8.7
SAC2 8.6
40S ribosomal protein S2 8.6
USP42 8.6
Melastatin 2 8.6
LARP 8.6
SmG 8.6
NOS2 8.6
endothelial nitric oxide synthase 8.5
ARM1 8.5
alpha-actinin 2 8.5
DDAH1 8.5
IP3K 8.5
DDAH2 8.4
RHOQ 8.4
NOSIP 8.4
sphingomyelin phosphodiesterase 3 8.4
T2R14 8.4
Nostrin 8.3
NFKBIE 8.2
STARD5 8.2
MAX protein 8.2
DNA topoisomerase 2 8.2
TRIP11 8.2
TALK-1 8.2
NG30 8.2
soluble guanylyl cyclase 8.2
toll-like receptor 1 8.1
DBK 8.1
TALK-2 8.1
6-pyruvoyltetrahydropterin synthase 8.1
nitric oxide synthase 8.0
NMA 8.0
plasma membrane calcium ATPase 4 8.0
GCH 8.0
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Disease
Biphasic Synovial Sarcoma 12.1
high-grade salivary gland carcinoma 10.5
Peripheral T-cell lymphoma 10.5
Acute leukemia of ambiguous lineage 10.1
Diffuse Astrocytoma 10.1
Secretory Carcinoma 9.8
NINA 9.4
Schizophreniform Disorder 9.3
Anaplastic Astrocytoma 8.8
PDD 8.7
Gastrointestinal inflammation 8.6
Schizophrenia and other psychotic disorders 8.6
NAME 8.4
Unilateral renal artery stenosis 8.4
AD10 8.4
Synovial Sarcoma 8.4
angioimmunoblastic T-cell lymphoma 8.3
Autistic behavior 8.2
Diffuse astrocytoma 8.2
Imu 8.1
psychogenic psychosis 8.0
Ependymoblastoma 8.0
Composite lymphoma 8.0
chronic eosinophilic leukemia 7.9
Persistent pulmonary hypertension 7.7
NLPHL 7.7
mycosis fungoides/Sezary syndrome 7.6
Cellular angiofibroma 7.5
Asperger syndrome 7.3
VIN I 7.3
nonorganic psychosis 7.3
Dedifferentiated chondrosarcoma 7.2
Primary cutaneous anaplastic large cell lymphoma 7.2
Secondary pulmonary hypertension 7.1
Gastric bleeding 7.1
EPV 7.1
Arterial occlusive disease 7.0
DLBCL 6.9
Cutaneous pseudolymphoma 6.9
brief reactive psychosis 6.8
Liver mass 6.8
Subcutaneous panniculitis-like T-cell lymphoma 6.8
cyclothymia 6.8
VAIN 6.8
Pleomorphic carcinoma 6.7
Lissauer 6.7
T-cell lymphoma 6.7
Autonomic imbalance 6.7
PEComa 6.6
Ectopic ACTH syndrome 6.6
athymia 6.6
Primary mediastinal large B-cell lymphoma 6.6
anaplastic large cell lymphoma 6.6
Lennert's lymphoma 6.6
brain aneurysm 6.5
Vagina 6.5
PAPA 6.4
GCB-DLBCL 6.4
Nasal cavity 6.4
T-cell lymphomas 6.3
FHL3 6.3
crown gall 6.3
sCJD 6.3
infiltrating ductal carcinoma 6.3
T cell neoplasms 6.3
paraphilia 6.3
B-cell prolymphocytic leukemia 6.2
Diffuse large B-cell lymphoma 6.2
AILD 6.2
Trisomy 12 6.2
ovarian sarcoma 6.1
Carcinoma ex pleomorphic adenoma 6.1
Endothelial dysfunction 6.1
sexual sadism 6.1
Inflammatory disease 6.1
Medullary carcinoma 6.1
acute gastritis 6.0
paranoid personality disorder 6.0
T-cell prolymphocytic leukemia 6.0
Middle cerebral artery occlusion 6.0
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Symptom
Macula 6.2
elevated mood 5.4
Deafferentation 4.7
Lower urinary tract symptoms 4.5
Extrapyramidal symptoms 4.5
hyperoxia 3.8
Excitability 3.8
Psychiatric symptoms 3.8
meningism 3.7
hyperacusis 3.6
tenesmus 3.2
rundown 3.1
nipple discharge 3.1
hyperesthesia 3.0
POA 3.0
Decreased activity 3.0
hyperemesis gravidarum 3.0
nipple discharge 3.0
night sweats 2.9
memory loss 2.9
masculinization 2.8
forgetfulness 2.7
acute stress 2.5
hypercapnia 2.5
consciousness disturbance 2.4
functional recovery 2.4
incoordination 2.3
neurological disability 2.2
orofacial pain 2.2
HSA 2.1
polyuria 2.1
spasm 2.0
catatonia 2.0
nasal congestion 1.9
splenomegaly 1.8
constipation 1.8
chronic constipation 1.8
bitter taste 1.6
Neuropathic pain 1.6
hoarseness 1.6
skin damage 1.5
seizures 1.5
hypothermia 1.5
despair 1.4
abdominal discomfort 1.3
polydipsia 1.0
anorexia 0.9
bradykinesia 0.9
pallor 0.8
exhaustion 0.7
cachexia 0.6
hepatomegaly 0.6
fatigue 0.5
starvation 0.5
ataxia 0.5
pain 0.5
flushing 0.5
anesthesia 0.4
erythema 0.4
vertigo 0.3
cerebellar ataxia 0.3
tremor 0.2
thinning 0.2
overweight 0.2
apathy 0.1
diarrhea -0.0
syncope -0.1
headache -0.1
respiratory distress -0.2
paresthesia -0.2
numbness -0.2
ENT -0.3
analgesia -0.4
hypotonia -0.4
spasticity -0.6
myalgia -0.6
tinnitus -0.6
dyspnea -0.7
angina -0.7
collapse -0.7
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Drug
N-Hydroxyguanidine 10.5
7-Nitroindazole 9.8
2-Iminobiotin 9.5
Aminoguanidine 8.6
Benidipine hydrochloride 8.2
Platonin 8.2
Sulfaphenazole 8.1
Lubeluzole 8.1
Nitric Oxide 8.1
Avanafil 7.9
BH4 7.8
Equilin 7.8
Sivelestat 7.5
Arachidonic Acid 7.5
L-Homoarginine 7.5
Sodium Nitroprusside 7.5
Pralatrexate 7.1
Bisacodyl 7.1
Gabexate mesilate 6.9
Sesamol 6.8
Deflazacort 6.7
Mevastatin 6.7
Iron dextran 6.6
Sodium nitroprusside 6.5
Claforan 6.5
Glybenclamide 6.5
RPH 6.3
Lercanidipine 6.2
MEPM 6.1
Nafamostat mesilate 6.1
Midostaurin 6.1
Nebivolol 6.0
Sesame oil 6.0
Triptorelin 5.9
Naftidrofuryl 5.8
EDR 5.8
Pirarubicin 5.6
Romidepsin 5.3
Trandolapril 5.2
Cilostazol 5.0
Ketorolac 4.9
Molsidomine 4.9
Interferon beta 4.9
Rosuvastatin 4.9
Corn oil 4.8
Lead acetate 4.8
Methyldopa 4.8
2-Methoxyestradiol 4.7
EPL 4.7
AC2 4.7
Bexarotene 4.7
Vardenafil 4.7
SNL 4.6
Methylene blue 4.6
Agomelatine 4.6
ROS 4.5
Tannic acid 4.5
CIA 4.5
MDM 4.4
Bosentan 4.4
Angiotensin II 4.4
Bosentan 4.4
Photofrin 4.2
Swertia 4.2
Indomethacin 4.2
FAD 4.1
Aliskiren 4.1
GNA 4.0
Simvastatin 4.0
Bezafibrate 4.0
G418 4.0
Salicylate 4.0
Clofibrate 4.0
Zein 3.9
MRC 3.9
ICI 3.9
CPO 3.8
Levosimendan 3.8
Copaxone 3.8
IFN-gamma 3.8
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Enzyme
NOS 12.1
lysopine dehydrogenase 10.5
dimethylarginine dimethylaminohydrolase 8.3
NO synthase 8.3
6-pyruvoyltetrahydropterin synthase 8.1
proteasome ATPase 8.1
NADPH-diaphorase 7.9
GTP cyclohydrolase I 7.5
PGE2-9-ketoreductase 7.4
PKG 7.1
guanylate cyclase 7.0
arginase 6.9
argininosuccinate lyase 6.9
diaphorase 6.8
nicotinamide adenine dinucleotide glycohydrolase 6.8
ribulose 5-phosphate 3-epimerase 6.6
EC 1.7.7.1 6.5
RPH 6.4
cyclohydrolase 6.3
argininosuccinate synthetase 6.3
sepiapterin reductase 6.2
SNO 6.1
MHCK 6.0
diaphorase 5.9
glycine amidinotransferase 5.8
VIP1 5.7
NQO1 5.7
arginine decarboxylase 5.6
arginine decarboxylase 5.6
SPT 5.6
isopentenyltransferase 5.6
SpeB 5.6
PAT 5.5
prostacyclin synthase 5.5
NADPH oxidase 5.5
HC-Pro 5.4
NADPH oxidase 5.4
heme oxygenase 5.4
LMT 5.3
ribose-5-phosphate isomerase 5.3
NCED 5.3
endothelin-converting enzyme 5.1
6beta-hydroxylase 5.1
xanthine dehydrogenase 5.0
arginine deiminase 4.9
malonyl-CoA decarboxylase 4.9
STK 4.9
SPT 4.9
PDE 4.8
EPSP synthase 4.8
neuropsin 4.8
granule-bound starch synthase 4.8
xanthine oxidase 4.7
hydroxypyruvate reductase 4.6
hydroxypyruvate reductase 4.5
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.5
PIP kinase 4.4
nitrate reductase 4.4
superoxide dismutase 4.4
nitrate reductase 4.4
nitrate reductase 4.4
nitrate reductase 4.4
nitrate reductase 4.4
nitrate reductase 4.4
poly(ADP-ribose) glycohydrolase 4.4
starch synthase 4.4
AAE 4.4
CaMKII 4.4
glutaryl-CoA dehydrogenase 4.3
polyamine oxidase 4.2
AMP-activated kinase 4.2
MPP 4.2
eEF2 kinase 4.2
mercuric reductase 4.2
caspase-6 4.2
estrogen sulfotransferase 4.2
PHT 4.1
caspase-6 4.1
aconitase 4.1
phosphatidylinositol 3-kinase 4.1
more...
Compound
5-chloro-1,3-dihydro-2H-benzimidazol-2-one 12.1
C11H13N3O2S 11.1
C11H13N3O2S 11.1
4,6-pyrimidinediamine 10.5
C11H13N3O2S 10.5
4,6-pyrimidinediamine 10.5
N-(4-chlorophenyl)-N'-hydroxyguanidine 10.5
1,3(2H,4H)-isoquinolinedione 10.1
2-Aminoquinoline 10.1
4,6-pyrimidinediamine 9.8
CDEC 9.8
4,6-pyrimidinediamine 9.8
CDEC 9.8
Guazatine 9.3
Nopaline 9.2
C10H11N3O2S 9.1
N-hydroxyguanidine 9.0
p-Cresidine 8.9
ethanimidamide 8.8
7,8-Dihydrobiopterin 8.6
Sepiapterin 8.6
ADMA 8.6
IDC 8.6
Acetosyringone 8.3
NMA 8.3
Nitro-L-arginine 8.2
Mesoporphyrin 8.1
6-Keto-PGF1a 8.0
C6H8N2 8.0
p-Anisidine 7.8
Ferene 7.8
Cobinamide 7.8
Tetrahydrobiopterin 7.8
Equilin 7.7
benzoyl isothiocyanate 7.6
4-phenyl-3-butenoic acid 7.6
Schisantherin A 7.6
Schisantherin A 7.6
Biopterin 7.5
PPBP 7.5
8-Br-cGMP 7.4
DETA 7.4
SDMA 7.4
CIT 7.4
Ginsenoside Re 7.4
Aminoimidazole 7.3
Cerivastatin 7.3
Chlorzoxazone 7.2
nitric oxide 7.1
Nickel sulfate 7.1
Pterin 7.0
1,2-Naphthoquinone 7.0
COX 6.9
Sesamol 6.8
C6H12 6.8
C6H12 6.8
Aucubin 6.7
cGMP 6.7
AFU 6.6
propionyl-carnitine 6.6
Agmatine 6.6
Methylguanidine 6.6
1,3-benzodioxole 6.6
8-HETE 6.5
SC-58125 6.5
Diepoxybutane 6.5
1H-indazole 6.5
Apocynin 6.4
Tetrahydrocurcumin 6.4
Myricitrin 6.4
Tetrahydrouridine 6.4
arginine 6.4
Tempol 6.4
Canavanine 6.4
Disperse Orange 6.3
Phenanthrenequinone 6.3
DDMS 6.3
DAHP 6.3
Sodium cyanide 6.2
CYN 6.2
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