Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.5.1.19 (NOS)
 7,285 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The HENE-OX system (isoforms 1, 2 and 3) is the key enzyme in the oxygen dependent HEME catabolism pathway and cleavage to HEME into biliverdin IX alfa, iron and carbon-monoxide (CO). The biliverdin reductase catalyzes biliverdin into bilirubin unconjugated what is converted in bilirubin conjugated, mono and biglucuronized for the activity of hepatic Uridindifosfo-glucuronil-transferase (UDFGT). The hyperbilirubinemias unconjugated can produce kernicterus. This should be treated with metalloporphyrins (Zn-Proto IX, Zn-Mesoporphyrin, Sn-Proto-IX, Sn-Mesoporphyrin). Relations between HEM-OX/CO and NOS/NO systems. The induction of the HEME-OX system is a protective cellular mechanism against oxidative damage. Studies about the relations of the HEME-OX system with functions of various tissues (liver, kidney, cardiovascular and respiratory and hematological system, etc.).
 ...
PMID:[The heme oxygenase system and its physiopathology]. 1084 82