Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.3.13 (lysyl oxidase)
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Human Gene/Protein
protein-lysine 6-oxidase 14.6
Protein-lysine 6-oxidase 14.6
LOXL3 protein 14.6
lysyl oxidase 14.4
lysyl oxidase-like 3 14.3
LOXL3 13.7
angiopoietin-related protein 2 13.6
LOXL 13.6
golgin-like protein 13.6
LOXL4 13.4
lysyl oxidase-like protein 13.3
LOXL4 protein 13.1
KIAA0709 13.1
ankyrin repeat domain 37 13.1
CGI-15 13.1
LOXL2 13.0
LOXL1 12.9
visual system homeobox 1 12.6
Paired box 7 12.6
lysyl oxidase-like 2 12.6
fibulin-4 12.6
collagen, type IV, alpha 1 12.3
lysyl oxidase-like 1 12.1
Lysyl oxidase-like 1 12.1
collagen type X alpha 1 12.1
PC43 11.8
Bcl-2-associated athanogene 2 11.8
lysyl hydroxylase 2 11.8
EFEMP2 11.6
alpha 2 type I collagen 11.6
FBLN4 11.6
EGF-like domain-containing protein 3 11.5
APMAP 11.3
elastin precursor 11.2
ASTL 11.2
tropoelastin 11.1
ADAMTS8 11.1
DANCE 11.0
Lysyl hydroxylase 10.9
lysyl hydroxylase 10.9
Insulin-like growth factor-binding protein 5 10.8
microfibril-associated glycoprotein 10.7
down-regulated in human cancers 10.7
PCPE 10.6
XFS 10.6
AVEN 10.6
procollagen I N-proteinase 10.6
lysyl hydroxylase 1 10.6
32kD 10.6
ADAMTS14 10.5
RARRES1 10.4
AMAP1 10.3
ADAMTSL4 10.3
Fibromodulin 10.3
LOK 10.2
FMOD 10.2
Hpa2 10.2
PLOD2 10.1
LOX 10.1
MAGP 10.1
BMP1 10.1
transcription factor AP2 10.1
amine oxidase 10.0
PLOD3 10.0
cMG1 10.0
VGLL3 10.0
MAGP-2 9.9
Friend leukemia virus integration 1 9.9
GALNT14 9.9
KCNJ3 9.9
CHM1 9.8
SLC31A1 9.8
ADAMTSL2 9.8
EDS VI 9.8
elastin 9.8
FBLN5 9.8
Cysteine-rich protein 9.8
Dermatopontin 9.8
EGFL7 9.8
MEMO 9.7
more...
Disease
Ehlers-Danlos syndrome type IX 14.1
stage II gastric cancer 11.3
Ehlers-Danlos syndrome type VII 10.7
EDS5 9.9
EDS VI 9.8
Induratio penis plastica 9.7
Subfertility 9.6
Copper deficiency 9.3
ED4 9.3
XFS 9.1
EDS IV 9.1
Menkes 9.1
Peritoneal metastases 9.0
cutis laxa 8.9
Left ventricular diastolic dysfunction 8.7
Oral submucous fibrosis 8.6
Functional mitral regurgitation 8.5
Bone fragility 8.5
OHS 8.4
familial hyperlipidemia 8.4
Intestinal infection 8.2
Malignant disease 7.9
Thoracic aortic aneurysm 7.8
Ehlers-Danlos syndrome type IV 7.7
optic nerve glioma 7.6
cancer angiogenesis 7.5
trichorrhexis 7.4
Recessive dystrophic epidermolysis bullosa 7.4
Gingival overgrowth 7.3
Aspartylglucosaminuria 7.2
Ehlers-Danlos syndrome 6.9
Selenium deficiency 6.8
BCD 6.8
dental root 6.7
arachnodactyly 6.7
keratoconus 6.7
Costello syndrome 6.4
balanitis 6.3
potassium deficiency 6.1
osteogenesis imperfecta 6.0
Marion 5.9
Dupuytren 5.9
generalized disease 5.8
MEN 2B 5.8
liver fibrosis 5.8
collagen disease 5.8
connective tissue disease 5.8
pulmonary fibrosis 5.8
benign nevi 5.8
homocystinuria 5.8
osteochondrosis 5.7
idiopathic pulmonary fibrosis 5.7
yaws 5.6
Aortic dissection 5.6
chronic persistent hepatitis 5.5
collagen disease 5.5
localized scleroderma 5.5
oropharyngeal squamous cell carcinoma 5.5
Marfan syndrome 5.4
vitamin C deficiency 5.4
emphysema 5.3
familial hemophagocytic lymphohistiocytosis 5.3
Kearns-Sayre syndrome 5.3
hyperhomocysteinemia 5.3
osteoporotic fracture 5.3
EDA 5.2
MEN 2 5.2
aortic aneurysm 5.1
COL2A1 5.1
Congenital heart disease 5.1
uveal melanoma 5.0
anaplastic thyroid cancer 5.0
laryngeal squamous cell carcinoma 5.0
hypertensive heart disease 5.0
restrictive cardiomyopathy 5.0
tumor progression 4.9
chorioamnionitis 4.9
Lip 4.9
abdominal aortic aneurysm 4.9
metastatic breast cancer 4.9
more...
Symptom
Blotchy 10.6
Stiffness 5.7
halitosis 5.4
emaciation 4.6
fasciculation 4.3
thinning 3.8
hyperoxia 3.3
regurgitation 3.2
hoarseness 3.1
starvation 2.0
respiratory distress 2.0
spasm 1.8
acidity 1.8
hypercapnia 1.7
back pain 1.1
functional recovery 0.9
anorexia 0.9
diarrhea -0.2
anesthesia -0.5
weakness -0.6
seizures -0.7
pain -3.4
Drug
Axokine 11.5
Gly-Tyr-Gly 9.2
Benzylamine 8.8
Triptorelin 8.4
Torasemide 7.9
Trapidil 7.8
Sulprostone 7.7
Areca 7.6
Dilantin 7.3
Pyridoxal 6.6
Botox 5.9
lysine 5.9
Orphan 5.6
pyridoxal phosphate 5.3
Pilocarpine 5.3
Gelfoam 5.1
Aprotinin 4.8
Monensin 4.7
Isoniazid 4.7
Reserpine 4.7
Doxycycline 4.5
Etoposide 4.5
CoCl2 4.4
CoCl2 4.4
Vitamin B 4.3
CCL 4.3
Phenytoin 4.3
Vitamin K 4.2
Gleevec 4.1
PTC 3.9
DHT 3.5
DHT 3.5
Imatinib 3.4
Fraction 3.3
Forskolin 3.3
Asn 3.1
Heme 3.0
ascorbate 3.0
HCH 2.9
niacin 2.8
ABC 2.5
Adriamycin 2.5
Angiotensin II 2.3
CSF 2.3
Glutathione 2.2
CTX 2.2
CTX 2.2
PTH 1.9
EPA 1.8
Gel 1.8
EE2 1.7
Nephron 1.5
CTX 1.3
Nephron 1.1
Dermatol 0.9
IFN-gamma 0.8
vitamin E 0.5
ROS 0.4
Cardiovasc -0.4
Enzyme
lysyl oxidase 14.6
lysyl hydroxylase 10.9
procollagen C-proteinase 10.7
diamine oxidase 9.3
prolyl hydroxylase 9.1
adamalysin 8.4
gamma-butyrobetaine hydroxylase 8.3
galactosylhydroxylysyl glucosyltransferase 8.2
methylamine dehydrogenase 8.1
saccharopine dehydrogenase 7.8
astacin 7.7
hatching enzyme 7.6
calpain 3 7.4
Lod 7.0
ceruloplasmin 7.0
monoamine oxidase 6.8
type III procollagen 6.8
sulfhydryl oxidase 6.7
galactose oxidase 6.5
meprin 6.5
CCS 6.4
transglutaminase 6.4
Omi/HtrA2 6.2
Protein 2 5.9
calpain 3 5.9
polyamine oxidase 5.8
STK11 5.8
elastase 5.7
cathepsin S 5.7
collagenase 5.6
15-hydroxyprostaglandin dehydrogenase 5.3
acetolactate synthase 5.3
dopamine beta-hydroxylase 5.2
gamma-glutamylcysteine synthetase 5.2
peptidyl-prolyl cis-trans isomerase 5.0
methionine synthase 4.9
paraoxonase 4.9
MMP-3 4.9
cathepsin G 4.8
tyrosinase 4.8
methionine synthase 4.8
interstitial collagenase 4.8
cystathionine beta-synthase 4.7
chondroitinase 4.6
paraoxonase 4.6
methylenetetrahydrofolate reductase 4.6
MMP 4.6
methylenetetrahydrofolate reductase 4.6
5alpha-reductase 4.6
5alpha-reductase 4.6
chondroitinase 4.5
matrix metalloproteinase 2 4.5
pepsin 4.4
11beta-hydroxysteroid dehydrogenase 4.3
cathepsin D 4.2
phenylalanine hydroxylase 4.2
apyrase 4.1
aldose reductase 3.9
PRA 3.9
aconitase 3.9
focal adhesion kinase 3.9
PAM 3.8
TdT 3.8
phosphoinositide 3-kinase 3.7
cathepsin L 3.7
NADPH oxidase 3.6
NADH dehydrogenase 3.6
hormone-sensitive lipase 3.6
aldehyde dehydrogenase 3.5
aldehyde dehydrogenase 3.5
aldehyde dehydrogenase 3.5
NADPH oxidase 3.5
superoxide dismutase 3.5
laccase 3.5
carbonic anhydrase 3.4
DNA methyltransferase 3.4
PKG 3.3
aldehyde dehydrogenase 3.3
SPC 3.3
glucose oxidase 3.2
more...
Compound
BAPN 12.9
Bleomycin sulfate 11.1
Allysine 10.9
Desmosine 10.9
Erythorbic acid 10.6
5-hydroxyhexanoic acid 10.6
DL-Penicillamine 10.4
BKF 10.2
Aminocyclopropane 10.0
Homocysteine thiolactone 10.0
Cartap 10.0
Pyridinoline 9.8
Elastin 9.5
Allylamine 9.4
pentosidine 9.3
APN 9.2
Brucine 9.0
Hydroxylysine 8.9
Pyrroloquinoline quinone 8.8
Hinokitiol 8.8
Benzylamine 8.7
DMDP 8.7
Prochloraz 8.6
Amentoflavone 8.3
DMAB 8.2
Semicarbazide 8.0
Phenylhydrazine 8.0
8-quinolinol 7.7
8-quinolinol 7.7
8-quinolinol 7.7
8-quinolinol 7.7
8-quinolinol 7.7
8-quinolinol 7.6
Sorbinil 7.5
Latrunculin A 7.3
Withaferin A 7.2
Collagen 7.1
8-quinolinol 7.1
Pargyline 7.0
Mr 30 7.0
butanal 6.9
8-quinolinol 6.9
Hydroxyproline 6.8
sebacic acid 6.7
sebacic acid 6.7
hexuronic acid 6.6
Pyridoxal 6.6
Pamidronate 6.6
sebacic acid 6.6
tetrahydrothiophene 6.6
hexuronic acid 6.5
hexuronic acid 6.5
hexuronic acid 6.5
Carcinogen 6.5
CCS 6.4
Homocysteine 6.3
Homocysteine 6.3
Carvacrol 6.1
isonicotinic acid 6.1
Prone 6.0
Propidium iodide 6.0
Calcein 6.0
Keloid 6.0
aldehyde 5.9
copper 5.9
Iodo 5.8
MAOA 5.8
Cortisone 5.7
DPA 5.7
DPA 5.7
DPA 5.7
DPA 5.7
DPA 5.7
Coenzyme A 5.6
aldehyde 5.6
homocysteine 5.4
lysine 5.4
Digoxin 5.4
Pilocarpine 5.4
Tempol 5.3
more...