Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.3.13 (
lysyl oxidase
)
1,248
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The relationship between the soluble copper topaquinone amine oxidases, the membrane bound semicarbazide-sensitive amine oxidases and
lysyl oxidase
remains unclear. The stereochemical course of substrate oxidation has been determined for each enzyme type and these studies suggest that SSAO and
lysyl oxidase
are closely related mechanistically, and that they are distinct from the copper amine oxidases. Both
lysyl oxidase
and SSAO catalyze the oxidation of tyramine with removal of the pro-S hydrogen from
C-1
of this substrate. The copper amine oxidase enzymes that react with abstraction of the pro-S hydrogen from
C-1
of substrates do not exhibit a solvent exchange pathway. In contrast, this exchange occurs in
lysyl oxidase
and SSAO reactions. The organic cofactor in all three enzyme types is a quinone; however, the spectral features of phenylhydrazine and p-nitrophenylhydrazine-derivatized SSAO differ from those reported for all known topaquinone-containing enzymes. Cofactor identification is further complicated by the lack of the characteristic topa motif, Asn-Tyr-Asp/Glu, in
lysyl oxidase
and the absence of any sequence information for SSAO.
...
PMID:Stereochemistry and cofactor identity status of semicarbazide-sensitive amine oxidases. 858 72
