Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.3.13 (
lysyl oxidase
)
1,248
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The extracellular matrix (ECM) regulates numerous cellular events in addition to providing structural integrity. Among several protein and enzyme families implicated in functions of the ECM, the lysyl oxidases and ADAMTS proteins are known to participate in microfibril and elastic fiber formation as well as ECM-associated signaling. A yeast two-hybrid screen to identify
lysyl oxidase
(
LOX
) binding proteins identified ADAMTSL4 as a potential interactor. We demonstrate here that several members of the
LOX
and ADAMTS families interact with one another. Upon investigating the interaction between
LOX
and
ADAMTSL2
we found that the absence or inhibition of Lox affected
ADAMTSL2
molecular forms and reduced its tissue levels. Thus,
ADAMTSL2
stability and inter-molecular complexes may depend on the activity of lysyl oxidases.
...
PMID:Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. 2975 65
