Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.3.13 (
lysyl oxidase
)
1,248
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Small amounts of (+)-catechin (5 mg/kg body wt) administered intramuscularly to 8-day-old chicks raised the
lysyl oxidase
activity in aorta about 20%.
(+)-Catechin
had no effect on chicks that were copper-deficient. In the deficient chicks, (+)-catechin treatment prompted a substantially stronger increase in
lysyl oxidase
activity in response to CuSO4. The observed increments in
lysyl oxidase
activity in vivo were sensitive to inhibition by beta-aminopropionitrile (BAPN), suggesting that (+)-catechin was affecting the enzyme.
(+)-Catechin
in the assay medium partially inhibited
lysyl oxidase
activity. With excess copper ions present, (+)-catechin catalyzed a very strong release of volatile tritium from the substrate proteins. The release of tritium, indicative of
lysyl oxidase
activity, was not blocked by BAPN, suggesting that the activity in vitro was not enzyme catalyzed.
...
PMID:Evaluation of (+)-catechin action on lysyl oxidase activity in aortic tissue. 613 26
