Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.3.13 (lysyl oxidase)
 1,248 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bone fragility is one of the side effects of glucocorticoid (GC) use, even at low doses. An increase in fracture risk due to GC administration occurs immediately after beginning treatment. A number of GC-mediated effects are responsible for bone fragility. We demonstrated that GC administration deteriorates lysyl oxidase mediated collagen crosslink formation acting as a determinant of bone material properties (Saito M, et al., Calcified Tissue Int, 88 ; 314-424, 2011) . We reviewed the mechanism of low bone material quality by GC administration.
...
PMID:[Glucocorticoid and Bone. Collagen cross-link abnormalities in glucocorticoid induced osteoporosis]. 2517 8