Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.3.13 (
lysyl oxidase
)
1,248
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lysyl oxidase initiates cross-linkage of collagen and elastin by catalysing the formation of a lysine-derived aldehyde. In order to study cross-linking in scleroderma, we used monoclonal antibodies to
lysyl oxidase
to determine the localization of this enzyme in systemic and
localized scleroderma
, and compared the distributions obtained with that in normal skin. Using an indirect immunofluorescent antibody method and an avidin-biotinylated enzyme complex method, 11 cases of diffuse type of systemic scleroderma and seven cases of
localized scleroderma
were studied. In the oedematous stage of systemic scleroderma, intracellular and extracellular
lysyl oxidase
were remarkably increased in the dermis, particularly in groups around blood vessels. In the sclerotic stage of systemic scleroderma,
lysyl oxidase
was detected intracellularly in fibroblasts and extracellularly among collagen bundles between the lower dermis and the subcutaneous fat tissue. In
localized scleroderma
, a marked increase in
lysyl oxidase
was observed in mononuclear cells and fibroblasts near blood vessels in the lower dermis and in the subcutaneous fat tissue, in addition to the extracellular deposits between collagen bundles. The increase in
lysyl oxidase
in
localized scleroderma
was much more common than in the oedematous stage of systemic scleroderma. These findings indicated that intracellular and extracellular expression of
lysyl oxidase
expression was greater in sclerodermatous skin than in normal skin.
...
PMID:Increased expression of lysyl oxidase in skin with scleroderma. 855 21
