Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.3.11 (
glutamate dehydrogenase
)
4,437
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
NADH substrate inhibition of bovine liver
glutamate dehydrogenase
appears to be eliminated at enzyme concentrations above 0.5mg/ml. Since the inhibition cannot be restored by preincubation of the enzyme with any substrate or product combination, the release of inhibition had previously been considered the result of enzyme polymerization.
Benzene
-saturated solutions, however, increase the extent of enzyme polymerization without affecting the NADH inhibition. These and related control measurements demonstrate that the release of substrate inhibition is the result of a hysteretic transition of an enzyme central and transitory complex.
...
PMID:Hysteretic nature of NADH substrate inhibition of bovine liver glutamate dehydrogenase. 21 66
