Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Whole proteins of male and female adult Haemonchus contortus were analysed by immunoproteomic techniques. Approximately 662 and 680 spots were detected on proteome maps of male and female nematodes, respectively, stained with Coomassie brilliant blue G-250. There were 609 shared spots. Approximately 193 and 196 spots were recognised on Western blot maps of male and female nematodes, respectively, using antiserum from naturally infected goats as the source of primary antibodies. There were 129 gender-specific spots in male nematodes and 132 in females. Twenty-three shared immunogenic spots were identified by MALDI-TOF or MALDI-TOF-TOF mass spectrometry. These proteins included
glutamate dehydrogenase
(
GDH
), homologues of Dim-1, actin, globin-like excretory/
secretory protein
F6, glutathione S-transferase (GST), ATPase and glyceraldehyde-3-phosphate dehydrogenase.
GDH
and GST have been identified as immunogenic proteins of H. contortus previously, whereas the other proteins are newly recognised immunogenic proteins in this nematode.
...
PMID:Immunoproteomic analysis of whole proteins from male and female adult Haemonchus contortus. 1956 Sep 53
