Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The concentration of
glutamate dehydrogenase
(
GDH
) varies strongly between different organs and between different regions within organs. To permit further studies on the regulation of
GDH
expression, we isolated and characterized the rat gene encoding the
GDH
protein. This gene contains 13 exons and spans approximately 34 kbp. The
GDH
gene is present as a single, autosomally located copy in the Wistar rat genome, but shows an extensive restriction-fragment-length polymorphism for several enzymes. Promoter activity of the 5'-flanking sequence is shown by transient transfection experiments. The 5'-flanking sequence contains a TTAAAA sequence at position -29, instead of a consensus TATA box and, like many other TATA-less promoters, is characterized by a very high G + C content. In addition, consensus sequences for the binding sites of the transcription factors
Sp1
and Zif268 are present in the G + C-rich upstream region.
...
PMID:Isolation and characterization of the rat gene encoding glutamate dehydrogenase. 809 69
