Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The degeneration of serotonergic neurons increases the expression of
glutamate dehydrogenase
(
GDH
) in hippocampal astrocytes. This process was demonstrated to be independent of the serotonin level. At the same time, upregulation of tumor necrosis factor (TNF) alpha and interleukin (IL)-1 alpha mRNA were observed, whereas levels of transforming growth factor (TGF) beta 1 mRNA remained unchanged. The level of GDH mRNA was increased in primary cultures of hippocampal astrocytes treated with TNF alpha and
IL-1 alpha
suggesting that these cytokines act on the
GDH
metabolism. TNF alpha and
IL-1 alpha
induced an increase in
GDH
promoter activity in C8S (an astrocytic cell line) transfected with constructs containing 5' flanking genomic sequences of
GDH
driving the expression of a reporter gene. These observations suggest that cytokines may be signals that upregulate the astrocytic
GDH
expression in response to the degeneration of serotonergic terminals in the hippocampus.
...
PMID:Cytokines are increased in the rat hippocampus after serotonergic neuron degeneration and upregulate the expression of GDH, an enzyme involved in glutamate detoxification. 882 82
