Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of nucleotides: AMP, cAMP, ADP, ATP, GDP and GTP, on
glutamate dehydrogenase
(
GDH
) purified from the mealworm fat body was studied.
Guanine
nucleotides and ATP inhibited the enzyme strongly in both directions.
GDH
was partially protected from the inhibition by the addition of ADP to an assay medium. AMP and cAMP activated the enzyme slightly. The concerted effects of ADP and ATP indicate the importance of adenylate energy charge in the regulation of fat body
GDH
. It is suggested that
GDH
may play amphibolic role in the fat body and that the direction of
GDH
catalysed reaction is under strong influence of nucleotides. The enzyme may synthesize glutamate at high energy charge, but when the energy reserves are low, it oxidizes glutamate.
...
PMID:The effect of nucleotides on glutamate dehydrogenase from the mealworm fat body. 245 16
