Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The am8 mutant of Neurospora crassa is shown to have a double base-pair change, GTG for the normal TAG, at the 3' end of the second intron of the am (NADP-specific glutamate dehydrogenase, GDH) gene. The greater part of the mutant am transcript accumulates as two fragments hybridising to probes for sequences respectively upstream and downstream of the 5' end of the intron. Two processed transcripts approximating to normal full length mRNA were identified. In one the second intron was intact; in the other the second intron was spliced out through the use of an AAG sequence, 20 base-pairs into the third exon, as a 3' acceptor site. A GAG sequence, only four base-pairs downstream from the normal acceptor site, does not appear to be used.
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PMID:Alternative modes of mRNA processing in a 3' splice site mutant of Neurospora crassa. 153 88

The total activity and isoenzyme spectra of lactate dehydrogenase (EC 1.1.1.27), malate dehydrogenase (EC 1.1.1.37), glutamate dehydrogenase (EC 1.4.1.2) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49) were studied in the skin of sheep and their fetuses. There are 5 multiple molecular forms of LDG, 4--of GDG, 2--of MDG and 1--of G-6-PDG in the skin. It is established that the skin of adult sheep and fetus is similar as to the studied parameters.
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PMID:[Polymorphism of several dehydrogenases in the skin of sheep and their fetuses]. 671 69