Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of
aflatoxin B1
on Hybro-type chicks were determined. Seven day-old chicks of both sexes were fed a diet containing aflatoxin at 0.5 ppm for 4 weeks. When compared to the controls, body weights and efficiency of feed utilization were depressed in the aflatoxin-fed group. The activities of serum sorbitol dehydrogenase (SDH) and
glutamic dehydrogenase
(
GDH
) and concentrations of potassium were significantly elevated, and total protein and calcium levels were decreased in aflatoxin-fed chicks. There were no consistent differences in the concentrations of other serum constituents between the controls and test birds. Histopathological examinations of liver and kidney sections revealed typical lesions of aflatoxicosis. In the kidney, recovery was slow as indicated by the presence of vacuolation and necrosis of the cells of many renal convoluted tubules 3 weeks after withdrawal of the experimental ration.
...
PMID:Experimental aflatoxicosis in hybro-type chicks: sequential changes in growth and serum constituents and histopathological changes. 360 40
Single doses of
aflatoxin B1
(2 mg/kg, i.p.) caused significant increases in the activities of tau-glutamyl transpeptidase, 5'-nucleotidase, acid phosphatase and acid ribonuclease, and decreases in the activities of succinate dehydrogenase and glucose-6-phosphatase in liver, after 8 weeks. The level of lipid peroxides, DNA, RNA, and cholesterol increased while glycogen decreased. It also increased the serum level of transaminases, sorbitol dehydrogenase,
glutamate dehydrogenase
, lactate dehydrogenase, acid phosphatase, alkaline phosphatase, and bilirubin. Oral administration of picroliv (25 mg/kg/day for 15 days), a standardised iridoid glycoside fraction of Picrorhiza kurroa, 6 weeks after
aflatoxin B1
toxication, significantly prevented the biochemical changes induced in liver and serum of
aflatoxin B1
treated rats. The hepatocurative effect of picroliv and silymarin, a plant based standard hepatoprotective are comparable.
...
PMID:Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. 1119 26
