Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have investigated the role of serotonergic neurons on the astrocytes catabolism of glutamate by analyzing glutamine synthetase (GS) and
glutamate dehydrogenase
(
GDH
) expression in the hippocampus after the degeneration of serotonergic neurons by a specific neurotoxin (5,7-
DHT
). 5,7-
DHT
caused reactive gliosis with hypertrophy (increase in glial fibrillary acidic protein (GFAP) expression) but not proliferation of astrocytes. Glutamate metabolism appeared preferentially regulated by a control of
GDH
expression rather than GS since the expression of
GDH
was specifically and significantly induced in the hippocampus whereas the level of GS remained unchanged. The inhibition of serotonin synthesis (by para-chlorophenylalanine (p-CPA) administration) produced no significant increase of
GDH
level. This suggests that serotonin is not the principal factor involved in this control of
GDH
expression.
...
PMID:Modifications of glial metabolism of glutamate after serotonergic neuron degeneration in the hippocampus of the rat. 785 35
