Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three fractions, A, B and C, were separated from rat liver inner mitochondrial membranes by sonication and centrifugation on a discontinuous sucrose gradient, and their distribution of enzyme activities, cytochromes and proteins was studied, in order to obtain data about the heterogeneous composition of the inner membrane. Fraction C was mitochondrial matrix. It contained about 90% of glutamate dehydrogenase activity, and its protein distribution in polyacrylamide gels was similar to that of mitochondrial matrix. Fraction B, with nearly 85% of enzyme activities and cytochrome contents of control inner membranes, would correspond to the crista membrane. Only 4% of cytochromes and enzyme activities of the inner membrane were found in fraction A, which would be the inner peripheral membrane, in contact with the outer membrane.
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PMID:[Distribution of proteins and enzymes in 3 submitochondrial fractions isolated from the internal mitochondrial membrane of the rat liver]. 350 89