Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

UVA light photodamages epidermal cells, as measured by inhibition of enzymatic activity and inhibition of respiration. This photodamage is greatly augmented in the presence of protoporphyrin as a photosensitizer. The increase in photodamage is greater for the cytosolic and mitochondrial enzymes lactate dehydrogenase and glutamate dehydrogenase and least for the lysosomal enzymes beta-glucuroninidase and N-acetyl-beta-glucosaminidase. Upon irradiation in the presence of protoporphyrin, N-acetyl-beta-glucosaminidase is released from the epidermal cells. These results may help to explain some features of the pathogenesis of erythropoietic protoporphyria.
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PMID:Porphyrin-induced photodamage to isolated epidermal cells from hairless mice. 369 45

Porphyrin-induced photodamage has been studied on small organic molecules, biomolecules, mitochondria and red cells. Water soluble components (e.g. tryptophan and glutamate dehydrogenase) are more easily destroyed by uroporphyrin than by protoporphyrin. On the other hand, lipophilic components (e.g. succinate dehydrogenase, mitochondria and red cell membranes) are more severely damaged by protoporphyrin. The results may be of importance to explain the different skin lesions in erythropoietic protoporphyria and in porphyria cutanea tarda. The photodamage is enhanced by D2O and reduced by azide. Reagents known to increase or decrease the yields of superoxide, peroxide or hydroxyl radicals have no effect on the photodamage. The results suggest that singlet oxygen is the most important reactive oxygen species.
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PMID:Porphyrin-induced photodamage at the cellular and the subcellular level as related to the solubility of the porphyrin. 747 96