Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histochemistry was used to study the activity of glutamate dehydrogenase (GDH) in neurons of g. nodosum of immobilized rabbits with acute experimental emotional stress induced by electrical stimulation of ventromedial hypothalamic nuclei and hind limbs. In control animals, GDH activity was found to vary in neurons of different size. The highest activity was recorded in large cells, whereas small cells showed the minimum activity. In experimental animals, GDH activity rose, the level of activity being almost equal in all the neurons.
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PMID:[Changes in the glutamate dehydrogenase activity of nodose ganglion neurons in rabbits in acute experimental emotional stress]. 719 92

Cell bodies of cardio-vascular receptors localized in the ganglion nodosum of rabbits exposed to experimental emotional stress were studied with the light and electron microscope and histochemically. Under emotional stress some rabbits demonstrated almost unchanged arterial pressure and only a small increase in heart rate, while other animals displayed strongly marked disturbances of their blood circulation leading to the acute heart deficiency at the end of the experiment. In the stress-resistant rabbits, microscopic anatomy and ultrastructure of neurons indicated their increased activity. Activities of lysosomal enzymes--acid phosphatase and aminopeptidase--were found to be at the control level, while the activity of mitochondrial enzyme--glutamate dehydrogenase--was slightly increased. On the other hand morphological evidence of severe hyperactivity and exhaustion was revealed in neurons of the stress-predisposed rabbits. Moreover the activities of all three enzymes studied were significantly increased. These results indicate correlation between the structural and metabolic changes occurring under experimental emotional stress in nodosal neurons and the extent of hemodynamic changes.
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PMID:Changes in ganglion nodosum neurons associated with stress-related cardiac deficiency. 770 77

Quantitative cytochemical methods revealed the decrease of MAO activity (substrate--tryptamine) in the hippocampus of L-dioxytryptamine treated August rats genetically predisposed to emotional stress under the effect of delta sleep inducing peptide (DSIP). Activities of aminopeptidase and glutamate dehydrogenase were decreased in n.accumbens while changes of the activities of these enzymes were not significant in the layers III and V of sensomotor cortex and n.caudatus. In all brain structures Ache and MAO (substrate 5-hydroxytryptamine) activities were not influenced by DSIP.
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PMID:[Changes in the enzyme activity in the brain structures of August rats under the influence of the delta sleep-inducing peptide against a background of prolonged L-dihydroxyphenylalanine administration]. 1070 90

The aim of this work was the comparative cytochemical study of some parameters of neurotransmitter and protein metabolism in the hippocampus (CA3 field) of August and Wistar rats, which were used as genetic-functional models demonstrating different brain organization, in particular, in respect to an emotional stress. Using quantitative cytochemical methods it was demonstrated that the activities of aminopeptidase, monoaminooxidase (substrates--tryptamine and serotonin), and glutamate dehydrogenase, were lower in the hippocampus of August rats (predisposed to emotional stress) as compared to that one in Wistar rats (resistant to emotional stress). August rats were also characterized by smaller sizes of neuronal cytoplasm and nuclei and by their lower protein content and concentration. The analysis of the data obtained has shown the existence of neurons with different modalities within the limits of CA3 hippocampal field, and these characteristics are thought to define the morphochemical differences in the hippocampus (CA3 field) of genetically different rats.
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PMID:[Morphochemical analysis of hippocampus of rats predisposed (August) or resistant (Wistar) to emotional stress]. 1523 64