Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

NAD- and NADP-dependent dehydrogenases in gastric adenocarcinoma and undifferentiated cancer cells were studied comparatively. The activity of NADP-dependent malate dehydrogenase, glutamate dehydrogenase and glucose-6-phosphate dehydrogenase was found to be high in gastric adenocarcinoma, while there was noted a more high activity of succinate dehydrogenase and NAD-dependent malate dehydrogenase in undifferentiated cancer. Differences ni the activity of oxido-reductive enzymes in adrenocarcinoma and undifferentiated cancer are discussed from the standpoint of various histogenesis of these forms of gastric cancer.
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PMID:[Oxidoreductase activity in the cells of stomach cancer]. 48 98

A rare isozyme of serum creatine kinase (CK) migrating cathodic to CK-MM on electrophoresis was found in a 30-year-old male with stomach cancer complicated by disseminated intravascular coagulation leading to massive upper gastrointestinal bleeding and marked anemia. Serum CK activity rose to a maximum of 374 U/l without detectable CK-MB isoenzyme. The patient was also characterized by a marked increase in serum lactate dehydrogenase (all isozymes elevated) and by preferential leakage of mitochondrial aspartate aminotransferase and glutamate dehydrogenase, indicating the presence of extensive tissue damage involving mitochondria. Skeletal muscle mitochondria were considered the most likely source of the additional CK isozyme.
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PMID:Cathodic isozyme of serum creatine kinase in a case of stomach cancer complicated by disseminated intravascular coagulation. 744 49

The activities of 6 dehydrogenases, lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PDH), isocitrate dehydrogenase (ICDH), glycerol-3-phosphate dehydrogenase (GDH), succinate dehydrogenase (SDH) and glutamate dehydrogenase (GLDH), determined by means of flow cytometry in 13 primary human gastrointestinal tumour cell lines, including 10 esophageal carcinomas, one gastric cancer, and 2 pancreatic cancers. Two-parametric measurements of specific dehydrogenase activities in single cells were performed with DAPI as fluorochrome for the nuclear DNA and with the fluorescent redox system of 5-cyano-2,3-ditolyl-tetrazolium chloride (CTC) which forms brilliant red formazan crystals upon reduction by cellular redox enzymes. Furthermore, with the aid of the calibration procedure reported previously [18] the enzyme activities were expressed as biochemical units. This application of tetrazolium salt technique for demonstrating dehydrogenase activities in human tumour cells by flow cytometry offers an alternative tool to characterize malignant tumors.
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PMID:Flow-cytometric determination of dehydrogenase activities in primary human gastrointestinal tumor cell lines. 816