Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.4.1.2 (
glutamate dehydrogenase
)
4,380
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Acute renal failure
induced by glycerol results in increased metabolism of glutamine by renal cortical slices of rats 16 and 36 hr after onset, and there is also increased glutamine uptake by the kidney in vivo. Metabolism of glutamine and glutamate to glucose is inhibited. At 8 days after onset of renal failure, metabolism of glutamine returns to normal. Initially, activities of phosphate-dependent glutaminase (PDG) and
glutamate dehydrogenase
are depressed. The activity of glutaminase returns to normal by 8 days, but
glutamate dehydrogenase
activity is still inhibited. Increased ammoniagenesis and glutamine uptake are mainly a result of increased entry into the cell since activity of glutaminase is inhibited.
...
PMID:Renal metabolism of glutamine in rats with acute renal failure. 613 Nov 57
