Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.4.1.2 (glutamate dehydrogenase)
 4,380 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of a total of 1,420 odontogenic cysts, 52 (3.3%) were diagnosed as odontogenic keratocysts. Clinical and histological findings in these 52 cysts are reported. Frozen sections of 26 of the keratocysts were incubated to show the following enzyme activities: NADH2- and NADPH2-diaphorase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase, acid phosphatase, leucine aminopeptidase and ATPase. Furthermore, keratinization was studied with the rhodamine B method and lipids with the oil red O, the OTAN and the acid hematein methods. Sections from epidermis, oral mucosa, radicular cysts, residual cysts and follicular cysts served as reference material. The oxidative enzymes showed strong activity in the keratocyst epithelium which contrasted with weak activity in the reference cysts. Acid phosphatase activity was weak in all epithelia except that in keratocysts, which displayed a marked activity. In the fibrous capsule of the keratocyst a high activity of leucine aminopeptidase was recorded. This high activity contrasted with a weak activity in the reference material. The significance of the histochemical results in relation to the aggressive behavior of the keratocyst is discussed.
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PMID:Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry. 14 97

Surgical and narcotic aggression lead to certain injuries of hepatocytes. The authors followed up the time course of liver injury marker enzymes in two groups of patients subjected to open cholecystectomy (n = 62): succinate dehydrogenase (SDH), glutamate dehydrogenase (GIDH), SGPT, and SGOT. In group 1 the operative trauma was minimal, in group 2 traumatism was higher because of technological difficulties. A high diagnostic significance of SDH and GIDH is worthy of note: their activities increase in proportion with the severity of surgical trauma. Comparison of laboratory data helps objectively assess the severity of operative injury in open cholecystectomy.
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PMID:[Hepatocyte cytolysis enzymes as the markers of operative trauma in open cholecystectomy]. 947 12