Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.99.3 (acyl-CoA dehydrogenase)
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Human Gene/Protein
acyl-CoA dehydrogenase 14.4
mitochondrial trans-2-enoyl-CoA reductase 14.4
FAM78A protein 14.4
medium-chain acyl-CoA dehydrogenase 14.4
long-chain acyl-CoA dehydrogenase 14.3
ACAD9 protein 14.0
acyl-CoA dehydrogenase 9 14.0
SBCAD 13.9
ACAD11 13.7
hSCAD 13.6
CDK5 regulatory subunit-associated protein 1 13.4
NADH dehydrogenase flavoprotein 1 13.4
Rrh 13.4
SACM1L 13.4
very-long-chain acyl-CoA dehydrogenase 13.3
isobutyryl-CoA dehydrogenase 13.2
ETFDH 13.1
long chain acyl-CoA dehydrogenase 13.1
ETFB 13.0
ACADSB 13.0
MCAD 12.9
ACAD9 12.9
acyl-CoA synthetase family member 2 12.9
ACSM4 12.9
LCAD 12.8
FLAD1 12.8
short-chain acyl-CoA dehydrogenase 12.8
Isovaleryl-CoA dehydrogenase 12.7
ACADM 12.7
VLCAD 12.7
electron transfer flavoprotein-ubiquinone oxidoreductase 12.7
ETFA 12.6
isovaleryl-CoA dehydrogenase 12.5
electron transfer flavoprotein ubiquinone oxidoreductase 12.4
ATP synthase gamma chain 12.4
OXSM 12.4
ACAD10 12.3
M/SCHAD 12.3
ETF-QO 12.2
ubiquinol-cytochrome c reductase binding protein 12.1
ACADVL 12.1
ACAD8 12.0
SCAD 11.9
Medium-chain acyl-CoA dehydrogenase 11.8
beta-ETF 11.8
GPR172B 11.6
DC12 11.6
ETF 11.6
mitochondrial 3-oxoacyl-CoA thiolase 11.5
NDUFB5 11.4
MOGAT2 11.4
CABC1 11.4
dienoyl-CoA isomerase 11.3
acyl-CoA synthetase long-chain family member 3 11.3
apolipoprotein A-I binding protein 11.3
Cytosolic malate dehydrogenase 11.3
enoyl-CoA hydratase 11.2
ACOXL 11.1
glutaryl CoA dehydrogenase 11.1
elongation of very long chain fatty acids protein 11.1
3-hydroxyacyl-CoA dehydrogenase 11.1
iron-sulfur protein 3 11.0
COQ6 11.0
CTP1 11.0
very long-chain acyl-CoA synthetase 11.0
2,4-dienoyl-CoA reductase 11.0
3-ketoacyl-CoA thiolase 11.0
peroxisome proliferative activated receptor gamma 10.9
SCHAD 10.9
alpha-actinin 2 10.9
3-hydroxy-3-methylglutaryl-CoA lyase 10.8
PDSS2 10.8
3-methylglutaconyl-CoA hydratase 10.7
ATP synthase F0 subunit 6 10.6
ADCK3 10.5
CPT II 10.5
glutaryl-CoA dehydrogenase 10.5
N111 10.4
estrogen-related receptor alpha 10.4
COQ9 10.4
more...
Disease
MCAD deficiency 13.7
Disorders of mitochondrial metabolism 12.4
Fatty acid oxidation defects 12.1
glycinuria 11.4
Jordan's anomaly 11.3
HMG-CoA lyase deficiency 11.1
Organic acidemias 11.1
glutaric aciduria 11.0
Reye 11.0
Acute fatty liver 10.5
MILS 10.4
Fazio-Londe 9.9
MCC deficiency 9.8
Fasting hypoglycemia 9.7
propionic acidemia 9.6
Reye's syndrome 9.5
tyrosinosis 9.3
pediatric disorder 9.3
riboflavin deficiency 9.2
Reactive hypoglycemia 9.2
CPS deficiency 9.2
methylmalonic acidemia 9.1
Conduction disorders 8.6
Complex I deficiency 8.5
GA I 8.5
maple syrup urine disease 8.4
Neonatal diabetes mellitus 8.3
Carnitine deficiency 8.2
ornithine transcarbamylase deficiency 8.2
homocystinuria 8.2
phenylketonuria 8.0
Acute fatty liver of pregnancy 7.8
Inborn errors of metabolism 7.8
citrullinemia 7.7
lipidosis 7.7
Zellweger syndrome 7.6
IVA 7.5
orotic aciduria 7.5
Forbes 7.5
GSD I 7.4
hypoglycemic coma 7.4
galactosemia 7.4
hyperglycinemia 7.3
McArdle's disease 7.2
hyperphenylalaninemia 7.2
protein deficiency 7.2
enzyme deficiency 7.2
Central diabetes insipidus 7.2
SHS 7.2
SHS 7.1
hyperargininemia 7.1
sudden infant death syndrome 7.0
hypoglycemia 6.9
glycogen storage disease 6.9
metabolic disorder 6.8
LWS 6.8
paramyotonia 6.8
congenital hypothyroidism 6.8
tyrosinemia 6.8
thalassemia minor 6.7
myopathy 6.6
Barth syndrome 6.5
EMA 6.5
PRS 6.3
Canavan 6.2
MCD 6.2
congenital adrenal hyperplasia 6.1
Copper deficiency 6.1
LQT1 6.0
cardiomyopathy 6.0
mitochondrial disease 5.9
lipid disorder 5.8
ketosis 5.8
fatty liver 5.7
attention deficit disorder 5.7
RP11 5.7
AMD 5.7
Refsum disease 5.7
ASAT 5.7
gangliosidosis 5.7
more...
Symptom
Positive and Negative Symptoms 7.8
inanition 6.6
ketonuria 6.3
hypotonia 6.2
hepatomegaly 5.9
lethargy 5.8
Spots 5.6
myalgia 4.9
muscle cramps 4.6
weakness 4.5
hypertonia 4.2
vomiting 3.9
starvation 3.7
stridor 3.3
sleepiness 3.1
cyanosis 2.6
dysarthria 2.6
hypothermia 2.4
seizures 2.3
exhaustion 2.3
hyperoxia 2.1
fatigue 1.8
nausea 1.5
ataxia 1.5
regurgitation 1.4
dyspnea 1.3
nausea and vomiting 1.2
Ill 1.0
erythema 0.8
functional recovery 0.7
collapse 0.6
diarrhea 0.2
respiratory distress 0.2
angina 0.1
cough -0.1
overweight -0.2
anesthesia -1.3
pain -1.5
Drug
Rifater 10.1
Rifater 10.0
Sodium phenylbutyrate 9.6
FAD 8.7
Riboflavin 8.7
Coconut oil 7.8
Flavin 7.0
Lipidex 6.9
Tween 60 6.8
Liraglutide 6.7
Bezafibrate 6.3
Palmitoyl 6.3
EDR 6.1
SMP 5.9
Rosiglitazone 5.8
Bosentan 5.7
Bosentan 5.7
Glutamic acid 5.5
Dihydro 5.4
Clofibrate 5.3
PFA 4.5
NADH 4.4
AraC 4.4
Doxycycline 4.4
RFP 4.2
Serum albumin 4.2
IL-1ra 4.0
Vitamin K 4.0
ALA 4.0
Glycyrrhiza 4.0
citric acid 3.8
Tacrolimus 3.7
Fructose 3.6
Gel 3.4
ACT 3.4
Estrogens 3.3
pyridoxal phosphate 3.1
lysine 3.1
Glutathione 3.1
Retinoic acid 2.7
Kenyan 2.7
Glucagon 2.6
ROS 2.5
ABC 2.3
Ethanol 2.2
CAM 1.9
Asn 1.9
MAP 1.5
THF 1.5
DNase I 1.4
CTX 1.1
Leaf 0.0
CSF -0.5
Enzyme
acyl-CoA dehydrogenase 14.4
acyl-CoA dehydrogenase 14.4
electron transfer flavoprotein dehydrogenase 12.9
holocarboxylase-synthetase 12.9
isovaleryl-CoA dehydrogenase 12.5
branched-chain acyl-CoA dehydrogenase 12.3
anthranilate hydroxylase 12.1
butyryl-CoA dehydrogenase 12.1
anthranilate hydroxylase 12.1
long-chain acyl-coenzyme A dehydrogenase 12.1
melilotate hydroxylase 11.9
anthranilate hydroxylase 11.3
4-N-trimethylaminobutyraldehyde dehydrogenase 11.3
EC 5.3.3.8 11.2
3-hydroxyacyl-CoA dehydrogenase 11.0
desulfinase 11.0
2,4-dienoyl-CoA reductase 10.9
geranoyl-CoA carboxylase 10.9
3-hydroxyacyl-CoA dehydrogenase 10.8
acyl-CoA oxidase 10.6
FAD pyrophosphatase 10.4
glutaconyl-CoA decarboxylase 10.4
glutaryl-CoA dehydrogenase 10.4
acyl-CoA elongase 10.4
EC 3.1.2.14 10.2
ECH 10.2
3-hydroxy-3-methylglutaryl-CoA lyase 10.2
dimethylglycine dehydrogenase 10.2
isobutyryl-CoA mutase 10.1
dephospho-CoA kinase 10.1
KAT 9.8
trans-2-enoyl-CoA reductase 9.8
3-hydroxybutyryl-CoA dehydrogenase 9.7
sarcosine dehydrogenase 9.6
acyl-CoA synthetase 9.6
3-hydroxyacyl-CoA epimerase 9.6
NAO 9.6
rubredoxin reductase 9.5
glycine N-acyltransferase 9.4
malonyl-CoA decarboxylase 9.2
acyl-CoA synthetase 9.2
p-hydroxybenzoate hydroxylase 9.2
acetylornithine aminotransferase 9.1
p-hydroxybenzoate hydroxylase 9.1
ornithine cyclodeaminase 9.0
biotinidase 9.0
ribulose 5-phosphate 3-epimerase 8.9
SsuE 8.8
CPT 8.6
acetoacetyl-CoA thiolase 8.4
citrate synthase 8.4
LipB 8.2
aromatic amino acid aminotransferase 7.9
HMG-CoA synthase 7.9
heterodisulfide reductase 7.9
carnitine acetyltransferase 7.7
AlkA 7.6
pantothenate kinase 7.5
membrane-bound hydrogenase 7.5
malate synthase 7.4
riboflavin kinase 7.4
methylmalonyl-CoA mutase 7.4
phosphoserine phosphatase 7.4
acetyl-CoA carboxylase 7.3
acetyl-CoA synthetase 7.2
flavin reductase 7.2
cysteine conjugate beta-lyase 7.2
fatty-acid synthase 7.2
ubiquinol-cytochrome c oxidoreductase 7.1
propionyl-CoA carboxylase 7.0
propionyl-CoA carboxylase 7.0
diacylglycerol acyltransferase 7.0
glycolate oxidase 7.0
cystathionine gamma-synthase 7.0
lactate oxidase 6.9
beta-hydroxybutyrate dehydrogenase 6.9
aspartoacylase 6.9
phosphoglyceromutase 6.9
CPT 6.8
acyl carrier protein synthase 6.8
more...
Compound
4-cis-Decenoyl-CoA 14.4
alpha-Methylbutyryl CoA 14.4
dec-4-enoic acid 14.4
2-methylmalonamide 14.4
octanoyl-CoA 13.0
Crotonyl-CoA 12.6
undecylbenzene 12.4
Octanoylcarnitine 12.3
Ethylmalonic acid 12.1
C11H13NO3 12.1
Lauroyl-CoA 11.9
Decanoyl-CoA 11.9
3-Hydroxyglutaric acid 11.3
butyryl-CoA 11.3
Hypoglycin A 11.1
MEZ 10.8
2-octynoic acid 10.8
tetradecanedioic acid 10.7
3-methylcrotonyl-CoA 10.7
Palmitoyl-L-carnitine 10.6
4-methylhexanoic acid 10.4
5-hydroxyhexanoic acid 10.4
K486 10.4
10-hydroxydecanoic acid 10.2
10-hydroxydecanoic acid 10.1
3-hydroxypropionyl-CoA 10.1
3-hydroxybutyryl-CoA 10.0
2-methyl-2-butenoic acid 10.0
glutaryl-CoA 9.7
acetoacetyl-CoA 9.7
Biguanide 9.6
propionyl-coenzyme A 9.6
Oleoyl-CoA 9.6
3-hydroxyoctanoic acid 9.6
alpha-hydroxyisovaleric acid 9.4
palmitoyl-CoA 9.4
CoA 9.0
Normetanephrine 9.0
1,2,4-butanetriol 9.0
dodecanedioic acid 9.0
Acyl-CoA 8.9
hexanedioic acid 8.9
4-pentenoic acid 8.8
FAD 8.7
Riboflavin 8.6
Carnitine 8.6
3-buten-2-one 8.6
Hydroxyphenylacetate 8.6
hexanedioic acid 8.6
3-buten-2-one 8.4
4-heptanone 8.4
decanoic acid 8.4
Benazepril 8.3
decanoic acid 8.3
L-carnitine 8.1
6-APA 8.1
docosanoic acid 8.1
3-heptanone 8.0
9,12-octadecadienoic acid 8.0
3-heptanone 8.0
2-ethylhexanoic acid 8.0
2-ethylhexanoic acid 8.0
2-ethylhexanoic acid 7.9
octanoic acid 7.9
Tyrosol 7.9
Mercaptopropionic acid 7.8
dihydroxyacetone-phosphate 7.8
3-heptanone 7.8
octanoic acid 7.7
octanoic acid 7.7
octanoic acid 7.7
suberic acid 7.7
octanoic acid 7.7
Edrophonium 7.6
docosanoic acid 7.5
2-ethylhexanoic acid 7.5
pimelic acid 7.5
Piperidine 7.4
FMN 7.4
WY-14,643 7.3
more...