Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.3.99.3 (acyl-CoA dehydrogenase)
 1,425 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Subjective fatigue was quantified before and 20 days after uncomplicated elective abdominal surgery in 12 patients and compared with changes in heart rate, enzyme activities and skeletal muscle substrates before and after bicycle exercise for 10 min at 65 per cent of patients' preoperative maximum work capacity. Fatigue increased from a mean(s.e.m.) preoperative level of 2.5(0.5) arbitrary units to 4.6(0.5) on postoperative day 20 (P less than 0.01). Body-weight, triceps skinfold thickness and arm circumference decreased postoperatively (P less than 0.02). Postoperative values of muscle enzyme activities indicative of oxidative phosphorylation capacity (citrate synthase and 3-OH-acyl coenzyme A dehydrogenase) were lower than preoperative values (P less than 0.05). Lactate dehydrogenase was unaltered and resting values of muscle glycogen and adenosine triphosphate were higher after operation (P less than 0.05). In response to exercise, heart rate, muscle glucose, glucose-6-phosphate and lactate increased (P less than 0.05), while muscle glycogen and creatine phosphate decreased (P less than 0.05). Increase in postoperative fatigue correlated with the increase in heart rate (P less than 0.05), while no significant correlations were found between fatigue and muscle parameters. Our results suggest that lack of exercise and malnutrition may be of importance in the decrease in work capacity and in fatigue after operation.
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PMID:Skeletal muscle enzyme activities and metabolic substrates during exercise in patients with postoperative fatigue. 232 98

The pseudobranch in rainbow trout was investigated in order to clarify its metabolic and physiological function. Contents of lactate, glycogen, and glycerides and activities of carbonic anhydrase (CA), lactate dehydrogenase (LDH), and 3-hydroxy-acyl CoA dehydrogenase (HAD) were measured and compared with those in the gills and liver. Contents of lactate and glycerides, and activities of CA and HAD were higher in the pseudobranch than in the gills and liver. The results show that the pseudobranch is well equipped with enzymes (HAD and CA) suggested to be coupled to fatty acids breakdown and synthesis respectively. Lactic acid, possibly formed from glycogen and the glycerol component in glycerides, may be involved in the increase in blood P0 2 (Root effect) that is necessary to meet the oxygen needs of the eye. Pseudobranch carbonic anhydrase is probably involved in this process.
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PMID:Investigation of the pseudobranch organ in rainbow trout (Oncorhyncus mykiss): endogenous substrates and activities of carbonic anhydrase, lactate dehydrogenase, and 3-hydroxy-acyl CoA dehydrogenase. 2419