Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
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Human Gene/Protein
Yip1 domain family, member 6 11.9
C20orf135 11.9
transmembrane emp24 protein transport domain containing 7 11.9
transcription elongation factor B 11.9
ATP5G 11.9
C11orf57 11.9
protein phosphatase 2A regulatory subunit A beta isoform 11.9
HIST3H2BB 11.9
SDHA protein 11.5
transmembrane protein 127 11.2
SDH2 11.1
SDHC 11.0
SDHB 11.0
NADH dehydrogenase flavoprotein 1 10.9
Sec23 homolog B 10.9
cadherin EGF LAG seven-pass G-type receptor 1 10.9
QPs1 10.9
GLB1L 10.9
SDHC protein 10.9
mitochondrial ribosomal protein S14 10.9
EMI5 10.9
VSTM2A 10.9
succinate dehydrogenase subunit B 10.6
SEC24A 10.5
SDHA 10.4
PGAM1 protein 10.3
MAG5 10.3
22 kDa peroxisomal membrane protein 10.3
SnuCyp-20 10.3
transcription factor GATA-5 10.3
GRIPAP1 10.3
NARFL 10.3
SEC31L1 10.3
MRPL11 10.3
kin of IRRE like 10.3
SEC24B 10.1
SEC24 10.0
PGL 9.9
SCFD1 9.9
KIAA1391 9.9
SEC24C 9.9
pyruvate carboxylase, mitochondrial 9.9
SEC24D 9.9
DDP2 9.8
GFM1 9.8
ubiquinone biosynthesis protein 9.8
TMEM127 9.7
fumarate hydratase 9.6
cytochrome c-1 9.6
SCM-1beta 9.6
GOLT1A 9.6
MCART1 9.6
C13orf31 9.6
SPSB3 9.6
ATP5J2 9.6
La-related protein 4 9.6
MRPL44 9.6
Succinic dehydrogenase 9.6
SEC23B 9.5
SDH 9.5
BBF2H7 9.5
alpha-ketoglutarate dehydrogenase 9.5
complex I) 9.5
YIPF6 9.3
succinate dehydrogenase complex subunit A 9.3
tumor necrosis factor receptor superfamily member 1A 9.3
succinate dehydrogenase complex subunit B 9.3
Cyclin-dependent kinase inhibitor 1B 9.3
ribosomal protein S15a 9.3
NDUFB3 9.3
L-alpha-glycerophosphate dehydrogenase 9.3
NADH-coenzyme Q reductase 9.3
SLC25A32 9.2
UQCRC2 9.1
Nucleoside diphosphokinase 9.1
succinate dehydrogenase flavoprotein subunit 9.1
ACN9 9.1
SEC23A 9.1
Malic dehydrogenase 9.0
fumarase 9.0
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Disease
Deficiency of succinate dehydrogenase 11.9
Molybdenum deficiency 10.3
PGL4 10.3
PGL2 10.0
Severe childhood autosomal recessive muscular dystrophy 9.6
Complex II deficiency 9.6
Gigantism and acromegaly 9.3
Serum carnosinase deficiency 9.1
PGL3 9.0
vaginal neoplasm 8.9
Islet cell tumor 8.6
Fecal peritonitis 8.5
paraganglioma 8.3
Neonatal anoxia 8.1
CIIP 8.1
orbital disorder 8.1
Congenital fiber type disproportion 7.7
PORC 7.7
Liver mass 7.6
F5F8D 7.6
metastatic pheochromocytoma 7.5
Renal cortical necrosis 7.5
Medullary Thyroid Carcinoma 7.4
Richner-Hanhart syndrome 7.4
mitochondrial myopathy 7.3
MNGIE 7.3
Aspergillus flavus infection 7.2
recurrent pheochromocytoma 7.2
Hereditary Leiomyomatosis and Renal Cell Cancer 7.1
Tumor morphology 7.1
CDA II 7.0
MELAS 6.9
GH-secreting pituitary adenoma 6.8
Malignant pheochromocytoma 6.8
Klebs 6.8
mitochondrial disease 6.8
circulatory hypoxia 6.7
Brown-Vialetto-Van Laere syndrome 6.7
mitochondrial encephalomyopathy 6.6
Barth syndrome 6.6
MELAS 6.5
Keshan disease 6.5
Hippel 6.5
Leigh syndrome 6.5
dyserythropoietic anemia 6.4
NEK1 6.4
PDH deficiency 6.4
hyperglycinemia 6.4
stromal tumors 6.3
gastrointestinal stromal tumor 6.3
slow virus infection 6.3
Diabetic encephalopathy 6.3
Carotid body 6.3
Carotid body 6.3
Carotid body 6.3
Pearson's syndrome 6.3
MERRF 6.2
Oncocytoma 6.1
Oncocytoma 6.1
Oncocytoma 6.1
salpingo-oophoritis 6.1
methylmalonic acidemia 6.1
TGCT 6.0
Alpers 6.0
MEN 2 6.0
Parathyroid adenoma 6.0
Complex I deficiency 6.0
RP9 5.9
perinephritis 5.9
Central core disease 5.9
PMS 5.9
audiogenic epilepsy 5.9
HHG 5.9
DMM 5.8
Kearns-Sayre syndrome 5.8
chronic salpingitis 5.8
Gulf War Syndrome 5.8
silicotuberculosis 5.7
avitaminosis 5.7
FIH 5.7
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Symptom
Respiration stimulated 10.9
astasia 6.0
Fatigability 6.0
Hyperekplexia 5.5
Exercise intolerance 5.1
Decreased activity 4.9
ophthalmoplegia 4.6
Deafferentation 4.5
Extrapyramidal symptoms 4.3
tonic seizure 4.2
male subfertility 3.9
ketonuria 3.8
hyperoxia 3.7
neurological disability 3.7
hypotonia 3.6
chorea 3.5
hangover 3.4
fatigue 2.9
twitching 2.9
Anoxia 2.8
incoordination 2.7
ataxia 2.6
chronic constipation 2.6
collapse 2.5
leg edema 2.5
dystonia 2.5
weakness 2.4
myalgia 2.4
exertional angina 2.4
chest tightness 2.3
starvation 2.3
exhaustion 2.1
eds 1.9
flank pain 1.8
abnormal gait 1.8
cachexia 1.8
dysarthria 1.6
fasciculation 1.6
bitter taste 1.5
hepatomegaly 1.4
acidity 1.4
anosmia 1.4
hypothermia 1.3
abdominal discomfort 1.2
cerebellar ataxia 1.1
cyanosis 1.1
paresis 1.0
myoclonus 0.9
tinnitus 0.8
bradykinesia 0.7
masculinization 0.6
seizures 0.6
dry eye 0.6
functional recovery 0.5
paraparesis 0.5
lethargy 0.5
hoarseness 0.4
polyuria 0.4
flushing 0.3
exertional dyspnea 0.2
headache -0.0
erythema -0.2
acute stress -0.2
nausea -0.3
numbness -0.4
angina -0.4
insomnia -0.4
dyspnea -0.5
anesthesia -0.6
tremor -0.7
vomiting -0.7
stigma -0.8
vertigo -0.9
diarrhea -0.9
hypercapnia -1.0
syncope -1.2
respiratory distress -1.3
splenomegaly -1.3
Ill -1.5
discomfort -1.5
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Drug
Dymelor 10.9
Succinobucol 10.5
Trospectomycin sulfate 9.1
Hexobendine 8.8
Diastase 6.8
Betaloc 6.7
Avilamycin 6.6
Metoprolol tartrate 6.6
NADH 6.6
Mercaptopurine 6.6
Cimaterol 6.5
Peridinin 6.5
Imferon 6.2
FAD 6.0
Fennel 5.9
Vinpocetine 5.7
Naftidrofuryl 5.7
TMX 5.6
Ciprofibrate 5.6
3,4-Dihydroxyphenylalanine 5.6
Flavin 5.5
Photofrin II 5.5
1,8-Cineole 5.5
APM 5.4
Zinc sulfate 5.4
Zinc sulfate 5.4
citric acid 5.3
Nexavar 5.2
Riboflavin 5.1
Ammonium chloride 5.1
Mineral oil 5.0
Trandolapril 5.0
Idebenone 5.0
NBT 4.9
Chlorate 4.7
Abamectin 4.7
Lead acetate 4.6
Fenbendazole 4.6
CET 4.6
Sodium valproate 4.6
Pentostam 4.6
Podophyllum 4.6
Iodixanol 4.5
Pefloxacin 4.3
CTT 4.2
Diamminedichloroplatinum 4.2
Liraglutide 4.2
Mesalazine 4.1
ROS 3.9
Parkin 3.9
Parkin 3.9
Pravastatin 3.8
Furan 3.8
Bestatin 3.8
Pregnenolone 3.8
Ketotifen 3.8
CLS 3.7
CTM 3.6
Gemfibrozil 3.6
Lovastatin 3.6
Guanidine 3.5
Auranofin 3.5
Guanidine 3.5
Enrofloxacin 3.5
ascorbate 3.5
Piracetam 3.5
CTC 3.5
AraC 3.5
Flunitrazepam 3.4
Carotenoid 3.4
Zonisamide 3.4
Propofol 3.2
Adriamycin 3.2
Bosentan 3.2
Bosentan 3.2
CTC 3.2
beta-Galactosidase 3.2
Ramipril 3.2
ddI 3.1
MEA 3.1
more...
Enzyme
EC 2.3.2.10 11.9
succinate dehydrogenase 11.9
succinic dehydrogenase 11.4
oxaloacetate tautomerase 10.1
fumarate reductase 10.0
lactoyl-CoA dehydratase 9.6
fumarase 9.3
beta-hydroxybutyrate dehydrogenase 9.0
valine dehydrogenase 9.0
glyoxylate dehydrogenase 8.9
EC 1.1.99.16 8.9
alpha-ketoglutarate dehydrogenase 8.9
complex I 8.9
glycerol-3-phosphate dehydrogenase 8.8
glycerol-3-phosphate dehydrogenase 8.7
NADH dehydrogenase 8.7
ubiquinol-cytochrome c oxidoreductase 8.5
succinyl-CoA synthetase 8.5
isocitrate dehydrogenase 8.4
6-hydroxy-D-nicotine oxidase 8.4
malate dehydrogenase 8.4
aconitase 8.4
4-hydroxyproline 2-epimerase 8.3
L-aspartate oxidase 8.2
isocitrate dehydrogenase 8.2
thiosulfate dehydrogenase 8.2
beta-glycerophosphatase 8.2
diaphorase 8.2
citrate synthase 8.2
cytochrome oxidase 8.1
DHOdehase 8.1
FAD pyrophosphatase 7.9
glycerol 3-phosphate dehydrogenase 7.9
EC 1.2.1.16 7.8
myosin ATPase 7.7
malate oxidase 7.7
omega-amidase 7.7
glycerol-3-phosphate oxidase 7.6
2-nitropropane dioxygenase 7.5
glucose-6-phosphatase 7.5
KGOR 7.5
oxoglutarate dehydrogenase 7.4
p-cresol methylhydroxylase 7.4
3-hydroxyacyl-CoA dehydrogenase 7.3
lactic acid dehydrogenase 7.3
3-hydroxyacyl-CoA dehydrogenase 7.2
glycine dehydrogenase 7.2
glycine dehydrogenase 7.2
lactic acid dehydrogenase 7.2
SCS 7.2
DAP II 7.1
sarcosine dehydrogenase 7.1
glutamic dehydrogenase 7.1
CPR 7.0
succinic semialdehyde dehydrogenase 7.0
isopropylmalate isomerase 7.0
2-oxoglutarate decarboxylase 7.0
PDH 7.0
6-phosphogluconate dehydratase 7.0
heterodisulfide reductase 6.9
isocitrate lyase 6.9
diaphorase 6.9
malate synthase 6.8
glutamate dehydrogenase 6.8
glucose-6-phosphate dehydrogenase 6.8
glutamate dehydrogenase 6.8
acid phosphatase 6.8
chlorophyllase 6.8
dihydroorotate dehydrogenase 6.8
phosphofructokinase 6.8
cytochrome b6/f complex 6.8
dihydroorotate dehydrogenase 6.8
glutamate dehydrogenase 6.8
methylisocitrate lyase 6.7
acetate CoA-transferase 6.7
nepenthesin 6.7
phosphofructokinase 1 6.7
1-deoxy-D-xylulose-5-phosphate synthase 6.6
dimethylglycine dehydrogenase 6.6
phosphorylase 6.6
more...
Compound
Papyriferic acid 11.9
Ubisemiquinone 10.9
Morfamquat 10.9
Papyriferic acid 10.9
C18H16O8 10.3
Siccanin 10.3
Dyclonine 10.3
Gracillin 10.1
Malonate 10.1
Gardenin B 9.9
Neurosporene 9.9
sebacamide 9.9
Dyclonine 9.6
Decylubiquinone 9.6
Rugulosin 9.3
Rapanone 9.3
2-Heptyl-4-hydroxyquinoline-N-oxide 9.3
C6H10O4 9.1
Gardenin 9.1
Vitavax 9.1
TNBT 9.0
Delan 8.9
6-Methyluracil 8.8
3-Hydroxyglutaric acid 8.8
4-(2-aminoethyl)phenol 8.8
Luteoskyrin 8.8
K-38 8.6
Yangambin 8.6
Methylmalonic acid 8.4
Butin 8.3
succinic acid 8.2
1,3-Dinitrobenzene 8.2
ethyl 3,4-dihydroxybenzoate 8.1
C5H6O4 8.1
Xanthomicrol 8.0
Phosphoglycolate 8.0
2,2',5,5'-TCB 8.0
Fumarate 8.0
dimethyl malonate 8.0
Tolazamide 7.9
1H-indazole-3-carboxylic acid 7.8
2,4-DA 7.8
CoQ6 7.8
NPA 7.8
Topsin 7.7
Ferene 7.7
Benzyl Viologen 7.7
ubiquinol 7.6
Decursinol 7.6
Trimethyltin chloride 7.6
2-Hydroxyglutarate 7.6
Naphthazarin 7.6
Rubratoxin B 7.5
1-Anilinonaphthalene 7.5
Blue Tetrazolium 7.5
ubiquinone 7.4
Fe(CN)3 7.3
L-Gulonolactone 7.3
Pyrrolnitrin 7.3
Mono-n-butyl phthalate 7.3
Daminozide 7.2
3-MPA 7.1
Propiconazole 7.1
2-Oxoglutarate 7.1
Guanidinoacetic acid 7.0
Imexon 7.0
THP-ADM 7.0
2,5-hexanediol 7.0
Rotenone 7.0
Neoxanthin 6.9
DCIP 6.9
oxalacetate 6.9
BNP 6.8
Glutaric acid 6.8
2-methylcitric acid 6.8
Protopine 6.8
CoQ 6.8
Metipranolol 6.8
isocitrate 6.7
Econazole nitrate 6.7
more...