Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
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Human Gene/Protein
C20orf135 11.9
Yip1 domain family, member 6 11.9
C11orf57 11.9
transmembrane emp24 protein transport domain containing 7 11.9
HIST3H2BB 11.9
protein phosphatase 2A regulatory subunit A beta isoform 11.9
ATP5G 11.9
transcription elongation factor B 11.9
SDHA protein 11.5
transmembrane protein 127 11.2
SDH2 11.1
SDHC 11.0
SDHB 11.0
GLB1L 10.9
Sec23 homolog B 10.9
QPs1 10.9
VSTM2A 10.9
SDHC protein 10.9
mitochondrial ribosomal protein S14 10.9
EMI5 10.9
cadherin EGF LAG seven-pass G-type receptor 1 10.9
NADH dehydrogenase flavoprotein 1 10.9
succinate dehydrogenase subunit B 10.6
SEC24A 10.5
SDHA 10.4
SnuCyp-20 10.3
SEC31L1 10.3
NARFL 10.3
MAG5 10.3
PGAM1 protein 10.3
GRIPAP1 10.3
transcription factor GATA-5 10.3
kin of IRRE like 10.3
22 kDa peroxisomal membrane protein 10.3
MRPL11 10.3
SEC24B 10.1
SEC24 10.0
PGL 9.9
SEC24C 9.9
pyruvate carboxylase, mitochondrial 9.9
more...
Disease
Deficiency of succinate dehydrogenase 11.9
Molybdenum deficiency 10.3
PGL4 10.3
PGL2 10.0
Complex II deficiency 9.6
Severe childhood autosomal recessive muscular dystrophy 9.6
Gigantism and acromegaly 9.3
Serum carnosinase deficiency 9.1
PGL3 9.0
vaginal neoplasm 8.9
Islet cell tumor 8.6
Fecal peritonitis 8.5
paraganglioma 8.3
Neonatal anoxia 8.1
CIIP 8.1
orbital disorder 8.1
Congenital fiber type disproportion 7.7
PORC 7.7
Liver mass 7.6
F5F8D 7.6
metastatic pheochromocytoma 7.5
Renal cortical necrosis 7.5
Medullary Thyroid Carcinoma 7.4
Richner-Hanhart syndrome 7.4
mitochondrial myopathy 7.3
MNGIE 7.3
Aspergillus flavus infection 7.2
recurrent pheochromocytoma 7.2
Tumor morphology 7.1
Hereditary Leiomyomatosis and Renal Cell Cancer 7.1
CDA II 7.0
MELAS 6.9
GH-secreting pituitary adenoma 6.8
Klebs 6.8
Malignant pheochromocytoma 6.8
mitochondrial disease 6.8
circulatory hypoxia 6.7
Brown-Vialetto-Van Laere syndrome 6.7
mitochondrial encephalomyopathy 6.6
Barth syndrome 6.6
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Symptom
Respiration stimulated 10.9
astasia 6.0
Fatigability 6.0
Hyperekplexia 5.5
Exercise intolerance 5.1
Decreased activity 4.9
ophthalmoplegia 4.6
Deafferentation 4.5
Extrapyramidal symptoms 4.3
tonic seizure 4.2
male subfertility 3.9
ketonuria 3.8
hyperoxia 3.7
neurological disability 3.7
hypotonia 3.6
chorea 3.5
hangover 3.4
fatigue 2.9
twitching 2.9
Anoxia 2.8
incoordination 2.7
ataxia 2.6
chronic constipation 2.6
collapse 2.5
leg edema 2.5
dystonia 2.5
weakness 2.4
myalgia 2.4
exertional angina 2.4
chest tightness 2.3
starvation 2.3
exhaustion 2.1
eds 1.9
flank pain 1.8
cachexia 1.8
abnormal gait 1.8
dysarthria 1.6
fasciculation 1.6
bitter taste 1.5
hepatomegaly 1.4
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Drug
Dymelor 10.9
Succinobucol 10.5
Trospectomycin sulfate 9.1
Hexobendine 8.8
Diastase 6.8
Betaloc 6.7
Avilamycin 6.6
Metoprolol tartrate 6.6
NADH 6.6
Mercaptopurine 6.6
Cimaterol 6.5
Peridinin 6.5
Imferon 6.2
FAD 6.0
Fennel 5.9
Vinpocetine 5.7
Naftidrofuryl 5.7
TMX 5.6
Ciprofibrate 5.6
3,4-Dihydroxyphenylalanine 5.6
Flavin 5.5
Photofrin II 5.5
1,8-Cineole 5.5
APM 5.4
Zinc sulfate 5.4
Zinc sulfate 5.4
citric acid 5.3
Nexavar 5.2
Riboflavin 5.1
Ammonium chloride 5.1
Mineral oil 5.0
Trandolapril 5.0
Idebenone 5.0
NBT 4.9
Chlorate 4.7
Abamectin 4.7
Fenbendazole 4.6
Lead acetate 4.6
CET 4.6
Sodium valproate 4.6
more...
Enzyme
succinate dehydrogenase 11.9
EC 2.3.2.10 11.9
succinic dehydrogenase 11.4
oxaloacetate tautomerase 10.1
fumarate reductase 10.0
lactoyl-CoA dehydratase 9.6
fumarase 9.3
beta-hydroxybutyrate dehydrogenase 9.0
valine dehydrogenase 9.0
EC 1.1.99.16 8.9
glyoxylate dehydrogenase 8.9
alpha-ketoglutarate dehydrogenase 8.9
complex I 8.9
glycerol-3-phosphate dehydrogenase 8.8
glycerol-3-phosphate dehydrogenase 8.7
NADH dehydrogenase 8.7
ubiquinol-cytochrome c oxidoreductase 8.5
succinyl-CoA synthetase 8.5
isocitrate dehydrogenase 8.4
6-hydroxy-D-nicotine oxidase 8.4
malate dehydrogenase 8.4
aconitase 8.4
4-hydroxyproline 2-epimerase 8.3
L-aspartate oxidase 8.2
isocitrate dehydrogenase 8.2
beta-glycerophosphatase 8.2
thiosulfate dehydrogenase 8.2
diaphorase 8.2
citrate synthase 8.2
cytochrome oxidase 8.1
DHOdehase 8.1
FAD pyrophosphatase 7.9
glycerol 3-phosphate dehydrogenase 7.9
EC 1.2.1.16 7.8
myosin ATPase 7.7
malate oxidase 7.7
omega-amidase 7.7
glycerol-3-phosphate oxidase 7.6
2-nitropropane dioxygenase 7.5
glucose-6-phosphatase 7.5
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Compound
Papyriferic acid 11.9
Ubisemiquinone 10.9
Morfamquat 10.9
Papyriferic acid 10.9
C18H16O8 10.3
Dyclonine 10.3
Siccanin 10.3
Gracillin 10.1
Malonate 10.1
Neurosporene 9.9
Gardenin B 9.9
sebacamide 9.9
Decylubiquinone 9.6
Dyclonine 9.6
Rapanone 9.3
2-Heptyl-4-hydroxyquinoline-N-oxide 9.3
Rugulosin 9.3
C6H10O4 9.1
Gardenin 9.1
Vitavax 9.1
TNBT 9.0
Delan 8.9
3-Hydroxyglutaric acid 8.8
Luteoskyrin 8.8
6-Methyluracil 8.8
4-(2-aminoethyl)phenol 8.8
K-38 8.6
Yangambin 8.6
Methylmalonic acid 8.4
Butin 8.3
succinic acid 8.2
1,3-Dinitrobenzene 8.2
C5H6O4 8.1
ethyl 3,4-dihydroxybenzoate 8.1
Phosphoglycolate 8.0
2,2',5,5'-TCB 8.0
Xanthomicrol 8.0
Fumarate 8.0
dimethyl malonate 8.0
Tolazamide 7.9
more...