Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Male Wistar rats were exposed to 500, 1000 or 100 ppm as time-weighted average (t.w.a.) concentrations of dichloromethane vapour. The 1000 (t.w.a.) ppm exposure consisted of two 1-h peak concentrations (2800 ppm) on a basal exposure of 100 ppm. All exposures lasted for 6 h, 5 days weekly and for 2 weeks. The solvent burdens were analyzed in the perirenal fat samples which showed a relation to the dose with the highest values in the 1000 (t.w.a.) ppm exposures. The solvent concentrations increased in the perirenal fat between the two weeks of exposure. Blood carbon monoxide concentrations did not accurately reflect the body solvent burdens. Neurochemical effects also displayed a dose relationship, and included decreased succinate dehydrogenase activity in the cerebellum at the two higher doses and increased acid proteinase activity at 1000 ppm in the cerebrum. Withdrawal of the animals for 7 days from the 2-week exposure showed that the biochemical changes were largely abolished with the exception of decreased succinate dehydrogenase activity at 1000 ppm (t.w.a.).
 ...
PMID:Dose-related effects of dichloromethane on rat brain in short-term inhalation exposure. 616 9

Hypoglycemic activity was detected in dichloromethane:methanol extract (1:1) of leaves and twigs of Catharanthus roseus (family Apocynaceae), a traditionally used medicinal plant, using streptozotocin (STZ) induced diabetic rat model. Extract at dose 500 mg/kg given orally for 7 and 15 days showed 48.6 and 57.6% hypoglycemic activity, respectively. Prior treatment at the same dose for 30 days provided complete protection against STZ challenge (75 mg/kg/i.p.x1). Enzymic activities of glycogen synthase, glucose 6-phosphate-dehydrogenase, succinate dehydrogenase and malate dehydrogenase were decreased in liver of diabetic animals in comparison to normal and were significantly improved after treatment with extract at dose 500 mg/kg p.o. for 7 days. Results indicate increased metabolization of glucose in treated rats. Increased levels of lipid peroxidation measured as 2-thiobarbituric acid reactive substances (TBARS) indicative of oxidative stress in diabetic rats were also normalized by treatment with the extract.
 ...
PMID:Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. 1144 49

The infrared spectra (IR) of single-molecule-magnet manganese complexes [Mn12O12 (O2CC6H4-3-Cl)16 (H2O)3 (3ClC6H4COH)].(3-Cl-C6H4CO2H)(I) and [Mn12O12(O2CCH2Br)16 (H2O)4]x4(CH2Cl2)(II) were studied at high external pressure. The different pressure-induced phase transition pressures were observed for both complexes (complex I, 25-29 kbar) and (complex II, 29-35 kbar). Both were second-order pressure-induced phase transition. The possible changes from higher spin to lower spin happened near the phase transition pressure following the changes of their structures when undergoing the high pressures. The average value of pressure sensitivities in the low-pressure phase is unusually smaller (0.19 cm(-1) x kbar(-1)) than in the high-pressure phase (0.29 cm(-1) x kbar(-1)) in the complex I. On the contrary, the average value of the pressure sensitivities in the low-pressure phase is higher (0.34 cm(-1) x kbar(-1)) than in the high-pressure phase (0.23 cm(-1) x kbar(-1)) in the complex II as usually, which means that the possibility of compression is lower in the high-pressure phase than in the low-pressure phase.
 ...
PMID:[Pressure-tuning infrared spectral study on the single-molecule-magnet manganese complexes]. 1576 77