Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The histochemical profile of intrafusal fibres of muscle spindles and muscle spindle capsule were analysed in normal sural muscles of a rat. Weak activity of oxidative enzymes (NADH diaphorase, succinic dehydrogenase, lactate dehydrogenase) and creatine phosphokinase were found in bag1 and bag2 fibres, but the oxidative enzyme activity was moderate in chain fibres. High phosphorylase activity was demonstrated in bag fibres as well as in chain fibres. No differences could be detected in adenosine desaminase activity between these various intrafusal fibres. In the outer capsule of muscle spindles, high amount of type III collagen and elastin, but only small amount of type I collagen and fibronectin could be observed.
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PMID:Histochemical profile of muscle spindles of rat's sural muscles. 214 86

This study was based on the hypothesis that after tumour transplantation, fibroblast metabolism increases adjacent to a tumour and this increase correlates with an increase in certain components of the extracellular matrix. A serial histochemical study of the cellular metabolism and extracellular matrix in a fast-growing mammary rat carcinoma was designed. The model used was the N-nitrosomethylurea-induced adenocarcinoma. At 24, 48, 72 or 96 h after transplantation, tumours and surrounding tissues were excised and processed. Ribonucleic acid and succinate dehydrogenase stains were used to indicate cellular metabolism; the extracellular matrix was stained for collagen, elastin, acid mucopolysaccharides, mucoproteins, glycoproteins and glycolipids. The results of this histology were compared with the histology of nonneoplastic transplants. In subcutaneous tissue adjacent to neoplasia, fibroblasts were abundant and showed an increase in metabolism between 24-96 h; this was correlated with an increase in collagen. For nonneoplastic transplants, fibroblasts were present only at 96 h, and collagen increases did not occur. It is inferred from the results that the tumour transplant is responsible for the increase in fibroblast metabolism in vivo which in turn increases fibre production.
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PMID:Metastatic rat adenocarcinoma: histochemical evaluation of fibroblasts and extracellular matrix. 241 91