Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.3.5.1 (
succinate dehydrogenase
)
8,177
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
When fed a manganese-sufficient (20 ppm) diet, obese (ob/ob) mice have reduced levels of Mn in liver and brown adipose tissue (BAT), and depressed activities of
succinate dehydrogenase
(
SDH
) and
manganese-containing superoxide dismutase
(
MnSOD
) in BAT, compared to lean mice. Dietary Mn supplementation (200 ppm Mn) increased the Mn concentration in BAT in lean and obese mice and the Mn content of liver in the ob/ob mouse. Mn supplementation also led to an increase in the specific activities of
SDH
and
MnSOD
in BAT of lean and obese mice. In the obese mouse, these changes were paralleled by changes in the histological appearance of the tissue. The results indicate that the metabolism of Mn is altered in the liver and BAT of ob/ob mice, and that these alterations are responsive to dietary Mn supplementation.
...
PMID:Metabolic effects of dietary manganese supplementation in ob/ob mice. 400 99
