Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.3.5.1 (
succinate dehydrogenase
)
8,177
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The radioprotective agent WR-2721 is dephosphorylated to the free thiol form
WR-1065
in vivo. The effects of WR-2721,
WR-1065
and reduced glutathione on a mitochondrial lipid peroxidation system were compared. WR-2721 had no effect on mitochondrial lipid peroxidation in vitro, and could not prevent the inactivation of mitochondrial enzymes. Both
WR-1065
and glutathione were effective inhibitors of mitochondrial lipid peroxidation induced by ADP/Fe/NADPH or by ADP/Fe/ascorbate. Both thiols correspondingly delayed the free radical-mediated inactivation of
succinate dehydrogenase
and isocitrate dehydrogenase.
WR-1065
was able to reduce cumene hydroperoxide non-enzymatically, and proved to be weak substrate for glutathione peroxidase. The disulfide formed from
WR-1065
could be reduced by glutathione without the participation of glutathione reductase. A redox cycle is proposed between
WR-1065
, glutathione and glutathione reductase to explain the inhibitory effect of
WR-1065
on lipid peroxidation.
...
PMID:The effect of the radioprotector WR-2721 and WR-1065 on mitochondrial lipid peroxidation. 196 40
