Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.3.5.1 (
succinate dehydrogenase
)
8,177
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Trimethyltin chloride
(
TMT
) is a stabilizer by-product in the process of manufacturing plastic, which is a kind of very strong toxic substance, and has acute, cumulative and chronic toxicity.
TMT
may cause bradycardia in patients with occupational poisoning, the mechanism of which has not been reported. This study explored the mechanism of
TMT
resulting in bradycardia of C57BL/6 mice.
TMT
was administered to mice to measure heart rate, serum
succinate dehydrogenase
(
SDH
) level, and myocardial Na
+
/K
+
-ATPase activity and expression. The effects of
TMT
on myocardial apoptosis were observed by changing the expressions of caspase-3, Bax and Bcl-2 in myocardium. It was found that the heart rate and
SDH
activity in serum of mice gradually decreased with the increase of
TMT
dose compared with the control group. The activity and the expression of Na
+
/K
+
-ATPase in the heart tissue of mice exposed to
TMT
was measured and gradually decreased with the increase of dose and time. We measured the expression of Bcl-2, Bax, caspase-3 and cleaved caspase-3 in the heart tissues of
TMT
exposed mice and found that the expressions of Bax, caspase-3 and cleaved caspase-3 increased and the expressions of Bcl-2 decreased in the heart tissues of the
TMT
-exposed mice at different doses. With the extension of
TMT
exposure time, the expression of Bax and caspase-3 increased and the expression of Bcl-2 decreased in the heart tissues of
TMT
exposed mice. Our findings suggest the mechanisms of
TMT
resulting in bradycardia may be associated with the inhibited activity and decreased content of Na
+
/K
+
-ATPase, thus further leading to the changes of Bcl-2, Bax, caspase-3 and cleaved caspase-3 in the mice's ventricular tissues.
...
PMID:Mechanism in bradycardia induced by Trimethyltin chloride: Inhibition activity and expression of Na
+
/K
+
-ATPase and apoptosis in myocardia. 3287 54
