Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The activity of lactate dehydrogenase was inhibited in liver and kidney. Pyruvate dehydrogenase and succinate dehydrogenase activities were also inhibited in all the tissues except muscles. Fish were hypoglycemic and hyperlactemic after 120 days of exposure to chromium. The glycogen content increased in liver but decreased in muscles. Lactate dehydrogenase activity was inhibited in all the six tissues. The activity of pyruvate dehydrogenase decreased in liver, intestine, gill and muscles. In muscles succinate dehydrogenase activity was elevated but inhibition was recorded in other tissues.
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PMID:Enzymological and biochemical changes produced by chronic chromium exposure in a teleost fish, Channa punctatus. 683 20

Lesions to the entorhinal afferent of the hippocampus in rats caused marked changes in calcium transport into mitochondria. Pyruvate-supported calcium transport into mitochondria from the denervated hippocampus was decreased to a larger extent than succinate-supported transport, and adenosine triphosphate-supported transport was not significantly modified. Although cytochrome oxidase and succinate dehydrogenase activities were not significantly changed by entorhinal lesions, pyruvate flux through pyruvate dehydrogenase was significantly decreased, and this effect was correlated with changes in pyruvate-supported calcium transport. The active portion of pyruvate dehydrogenase decreased, whereas total pyruvate dehydrogenase was not modified. These data suggest that denervation might initiate dendritic atrophy and subsequent growth responses by modifying calcium regulation through a change in the phosphorylation of pyruvate dehydrogenase.
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PMID:Entorhinal cortex lesions induce a decreased calcium transport in hippocampal mitochondria. 707 88

The effect of acute exposure to LC50 for 96 h (3.1 mg/l) and chronic exposure to a sublethal concentration (0.31 mg/l) of diazinon has been studied in the liver, stomach, intestine and pyloric ceca of a freshwater teleost fish, Channa punctatus. In acute exposure succinate dehydrogenase (SDH) activity was elevated in intestine and pyloric ceca. No alteration was noted in lactate dehydrogenase activity but pyruvate dehydrogenase was inhibited in pyloric ceca. Chronic exposure resulted in inhibition of the activities of the three dehydrogenases in all the four parts at both intervals.
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PMID:Acute and chronic effects of diazinon on the activities of three dehydrogenases in the digestive system of a freshwater teleost fish Channa punctatus. 708 68

The effect of in vivo exposure to a sublethal concentration of hexavalent chromium for 30 days on blood glucose, blood liver and muscle lactic acid; haemoglobin, liver and muscle glycogen; and activities of lactate dehydrogenase (LDH), pyruvate dehydrogenase (PHD) and succinate dehydrogenase (SDH) in liver, muscle, kidney, gills and brain has been studied. Blood glucose and lactic acid levels were elevated. Liver glycogen was depleted but muscle glycogen content increase. The activities of LDH and SDH in liver were elevate. Elevation was also observed in muscle LDH and PDH activities, showing that the rate of glycolysis is increased. No change was noted in haemoglobin content of blood or in the activities of the three dehydrogenases in kidney and gills.
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PMID:Toxic effects of chromium in a freshwater teleost fish, Channa punctatus. 709 8

Alterations in the activities of alkaline phosphatase, acid phosphatase, glucose-6-phosphatase, succinic dehydrogenase, pyruvic dehydrogenase and lactic dehydrogenase in liver a teleost fish, Channa punctatus were examined after 7, 15 and 30 days treatments with 5 micrograms/l mercuric chloride. Observations have shown specific effects of Hg on these enzymes for a particular period. However, alkaline phosphatase, acid phosphatase, glucose-6-phosphatase were progressively inhibited by this element. Greater accumulation of Hg in liver after a longer treatment and the respective change in enzyme activity clearly showed a dose-response relationship.
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PMID:Mercurial toxicity in the liver of a freshwater teleost Channa punctatus. 709 18

The chronic toxic effects of cadmium (0.26 mg/l) on the carbohydrate metabolism of a teleost fish, Heteropneustes fossilis were examined after 15, 30 and 60 days of exposure. The alterations produced after 15 and 30 days of exposure were similar in nature but were different in fish treated for 60 days. Fish were hyperglycemic and hyperlactacidemic after 15 and 30 days of exposure. The liver and muscle glycogen content was depleted in the first two periods of exposure. In contrast, 60 days of cadmium treatment increased the glycogen content of the two tissues. Liver lactic acid level was elevated after 15 days. Muscle lactic acid content fell significantly after 15 and 60 days of exposure, but it was elevated after 30 days. In general, the activities of lactate dehydrogenase, pyruvate dehydrogenase and succinate dehydrogenase increased in liver, kidney, intestine, ovary, gills and muscles of fish exposed to cadmium for 15 and 30 days. The increase in activities of the three dehydrogenases continued up to 60 days in intestine and ovary. In gills succinate dehydrogenase activity was elevated after 60 days also, but pyruvate dehydrogenase was inhibited. The activities of the three dehydrogenases decreased in liver, kidney and muscles.
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PMID:Effect of cadmium on some aspects of carbohydrate metabolism in a freshwater catfish Heteropneustes fossilis. 715 15

Various dehydrogenases, reductases, and electron transfer proteins involved in respiratory sulfate reduction by Desulfovibrio gigas have been localized with respect to the periplasmic space, membrane, and cytoplasm. This species was grown on a lactate-sulfate medium, and the distribution of enzyme activities and concentrations of electron transfer components were determined in intact cells, cell fractions prepared with a French press, and lysozyme spheroplasts. A significant fraction of formate dehydrogenase was demonstrated to be localized in the periplasmic space in addition to hydrogenase and some c-type cytochrome. Cytochrome b, menaquinone, fumarate reductase, and nitrite reductase were largely localized on the cytoplasmic membrane. Fumarate reductase was situated on the inner aspect on the membrane, and the nitrite reductase appeared to be transmembraneous. Adenylylsulfate reductase, bisulfite reductase (desulfoviridin), pyruvate dehydrogenase, and succinate dehydrogenase activities were localized in the cytoplasm. Significant amounts of hydrogenase and c-type cytochromes were also detected in the cytoplasm. Growth of D. gigas on a formate-sulfate medium containing acetate resulted in a 10-fold increase in membrane-bound formate dehydrogenase and a doubling of c-type cytochromes. Growth on fumarate with formate resulted in an additional increase in b-type cytochrome compared with lactate-sulfate-grown cells.
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PMID:Localization of dehydrogenases, reductases, and electron transfer components in the sulfate-reducing bacterium Desulfovibrio gigas. 724 92

The study on the effect of some antibiotics on the activity of pyruvate dehydrogenase (PDG) and dehydrogenases of the tricarboxylic acid cycle (TAC) in the cell extracts of Bac. polymyxa 153 producing polymyxin B showed that the level of the reaction of the individual enzymes to the effect of various antibiotics was different. Specific sensitivity to polymyxins M and B was found in succinate dehydrogenase and that to polymyxin B in malate dehydrogenase. The activity of the first components of the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes was completely suppressed not only by polymyxins M and B but also by novobiocin, ristomycin and nistatin. The activity of NADP-dependent isocitrate dehydrogenase was not suppressed by either of the antibiotics tested.
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PMID:[Antibiotic action on Bacillus polymyxa 153 enzymatic activity]. 735 5

A comparative study was carried out on the glucose metabolism in Babesia microti (BM) and Babesia rodhaini (BR) by analyzing the enzyme activities. The lactate dehydrogenase (LDH) activity in BM showed significantly lower values than that in BR, whereas citrate synthase (CS) and malate dehydrogenase (MDH) activities were remarkably higher in BM. In addition, pyruvate dehydrogenase (PDH), isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (KGDH), and succinate dehydrogenase (SDH) activities also tended to be higher in BM. Then, the change of enzyme activities related to the proliferation of parasites was examined. In BM infected mice, the parasitemia increased from day 15 to day 19 after inoculation (a.i.). While BM showed decrease of G6PD and LDH activities at day 19 a.i., it showed remarkably increased activities in CS and MDH (368 and 8,842 nmol/min.mg protein, respectively). In addition, PDH, ICDH, KGDH, and SDH activities also tended to increase from day 15 to 19 a.i. In BR infected mice, parasitemia increased from day 9 to day 12 a.i. LDH activity showed a considerable increase at day 12 a.i. (12,920 IU/mg.protein). Although CS and MDH activities also showed a slight increase at day 12 a.i., the activities of PDH, ICDH, KGDH and SDH didn't change from day 9 to 12 a.i. Since these changes observed in the enzyme activities of BM and BR seemed to be correlated with their proliferation, it was suggested that BM and BR depended on aerobic and anaerobic pathways, respectively, for their glucose metabolism.
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PMID:Enzyme activities related to glucose metabolism in Babesia microti and Babesia rodhaini. 775 34

Changes in the rates of glycolysis, glycogenolysis, activities of pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, serum glutamic pyruvic and oxaloacetic transaminases in the brain hemispheres and stem of rats exposed to 5-7 hypoglycemic comas were studied. No noticeable changes were detected in glycolysis intensity or activities of Krebs' cycle enzymes in the large hemispheres. The intensity of glycogenolysis and activities of transaminases in the brain stem reduce on day 2 of repair period after the last hypoglycemic coma. The detected changes result from multiple exposures of the brain to hypoglycemia and may be important in the development of posthypoglycemic encephalopathy.
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PMID:[Intensity of glycolysis and activity of energy metabolism enzymes in rat brain after multiple exposures to hypoglycemic doses of insulin]. 789 47


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