Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Specific effects of various catecholamines as well as functional dependence of mitochondrial enzymes activity on catecholamine metabolism were studied. Dopamine activated cytochrome c oxidase in heart mitochondria and decreased this enzymatic activity in liver tissue. Noradrenaline and adrenaline activated cytochrome c oxidase in liver, brain and kidney tissues. The effect of dopamine on cytochrome c oxidase was prevented by activation of dopamine beta-hydroxylase. Increased activity of monoamine oxidase caused accumulation of catecholamine metabolites, which inhibited the succinate dehydrogenase activity in liver tissue and the cytochrome c oxidase activity in brain, kidney and liver tissues. In the catecholamine regulation of succinate dehydrogenase and ATPase activities in all the tissues studied as well as of cytochrome c oxidase activity in heart tissue the quinoid oxidation products were apparently involved.
 ...
PMID:[Catecholamine metabolism and mitochondrial enzyme activity]. 612 94