Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diurnal rhythms are demonstrated in five rat liver enzymes : argininosuccinate synthetase, ATP : citrate lyase, glutamate dehydrogenase, phosphoenolpyruvate carboxykinase, and succinate dehydrogenase. In a 12 : 12 h light-dark cycle, maxima of enzyme activities occur at the beginning of the dark phase in the case of phosphoenolpyruvate carboxykinase, at the end of the dark phase in ATP : citrate lyase, and in the middle of the dark phase in the other three enzymes. The diurnal increase of phosphoenolpyruvate carboxykinase is blocked by cycloheximide, cordycepin, alpha-amanitin, and 5-azacytidine. The maximum of ATP : citrate lyase is likewise suppressed at the levels of both translation and transcription, as shown by administration of cycloheximide and 5-azacytidine, respectively. Hence, these two enzymes appear to be regulated transcriptionally. The diurnal rise of argininosuccinate synthetase an glutamate dehydrogenase is also totally inhibited by cycloheximide, whereas cordycepin, alpha-amanitin, and 5-azacytidine are ineffective in the first phase of enzyme accumulation. In a later phase, however, alpha-amanitin and 5-azacytidine become inhibitory. The two enzymes therefore seem to be regulated sequentially by post-transcriptional and transcriptional mechanisms. The diurnal increase of succinate dehydrogenase is nearly insensitive to alpha-amanitin and 5-azacytidine; cycloheximide is only partially inhibitory and, in particular, almost ineffective during the late rise. Thus, the rhythm of this enzyme might be controlled mainly by an activation and, perhaps, by a transitory post-transcriptional mechanism.
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PMID:Different levels of gene realization in the diurnal control of rat liver enzymes. 617 90

We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case.
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PMID:Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age. 2603 92