Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pirrolidone-2, gamma-butyrolacton, succinic anhydride were found to possess pronounced antihypoxic activity that manifested itself in their ability to decrease the level of lactic acid accumulated during hypoxia. Pirrolidone-2 and succinic anhydride increase succinic dehydrogenase activity in vitro. At intraperitoneal administration the above mentioned compounds lead to lactate dehydrogenase activity inhibition under normal conditions while during circulatory hypoxia they stimulate lactate dehydrogenase reaction promoting the maintenance of energy balance of the cerebral tissue at the appropriate level.
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PMID:[The antihypoxic activity of endogenous cyclic derivatives of gamma-aminobutyric acid]. 259 76

The purpose of the study was to examine the pattern of changes revealed in the metabolic reactions in the cerebral mitochondria, oxidizing succinates in acute circulatory hypoxia under the influence of hyper- and normoxic conditions of an experiment. Following 3.5 hours of acute circulatory hypoxia in the cerebral mitochondria which were resistant to bilateral carotid occlusion, rats showed increased succinate-dependent energy production, followed by compensatory inhibition of succinate dehydrogenase. The normoxic conditions of the cerebral mitochondrial investigations preserved succinate-dependent and transaminase respiratory fractions of organelles which were inhibited under hyperoxic conditions of an experiment. This improves more objective assessment of the responses of the mitochondrial oxidation system on the pathology model under study.
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PMID:[Effect of research conditions on succinate oxidation in brain mitochondria in circulatory hypoxia]. 915 70